|Association of lung function in a panel of young healthy adults with various chemical components of ambient fine particulate air pollution in Beijing, China|
|Wu, Shaowei1; Deng, Furong1; Wang, Xin1; Wei, Hongying1; Shima, Masayuki2; Huang, Jing1; Lv, Haibo1; Hao, Yu1; Zheng, Chanjuan1; Qin, Yu1; Lu, Xiuling1; Guo, Xinbiao1|
|关键词||Air Pollution Chemical Component Lung Function Metal Particulate Matter|
|WOS标题词||Science & Technology|
|类目[WOS]||Environmental Sciences ; Meteorology & Atmospheric Sciences|
|研究领域[WOS]||Environmental Sciences & Ecology ; Meteorology & Atmospheric Sciences|
|关键词[WOS]||HEART-RATE-VARIABILITY ; POSITIVE MATRIX FACTORIZATION ; HOSPITAL ADMISSIONS ; ATMOSPHERIC AEROSOL ; EXPOSURE ; MATTER ; PARTICLES ; URBAN ; PM2.5 ; SIZE|
Background: Ambient fine particulate air pollution has been associated with impaired lung function, but the chemical components behind the association are not well understood.
Objectives: We investigated the short-term effects of various air pollutants and chemical components of ambient fine particles (PM2.5) on lung function in a panel of 40 healthy university students.
Methods: The study subjects underwent biweekly spirometry tests for 12 times before and after their natural relocation from a suburban area to an urban area with changing air pollution levels and contents in Beijing, China. We estimated the short-term air pollution effects on lung function by applying four different mixed-effects models: single-pollutant model, component-PM2.5 joint model (two-pollutant model), component residual model, and exposure partitioned model.
Results: Among the air pollutants, PM2.5 showed the most robust estimated effects on different lung function measures in a similar action pattern. Most air pollutants and PM2.5 chemical components were positively associated with lung function measures at a short-term averaging time (3-d moving average) and inversely associated with them at a longer averaging time (14-d moving average). We found consistent positive associations between chloride, zinc, copper, vanadium, lead, stannum and different lung function measures at 3-d moving average. We also found consistent inverse associations between calcium, magnesium and peak expiratory flow at 14-d moving average.
Conclusions: Our findings suggest that PM2.5 and several metallic components may be the major air pollutants that contribute to the lung function changes. These findings may help achieve a better understanding of the features of a complex air pollution mixture that are most deleterious to health, and may also have implications for more targeted and effective pollution regulations aiming to improve the public health. (C) 2013 Elsevier Ltd. All rights reserved.
|项目编号||81072267 ; 2006BAI19B06 ; 2012AA062804|
|资助机构||National Natural Science Foundation of China ; National Key Technologies R& ; D Program of China ; National High Technology Research and Development Program of China ; Academic Award for Excellent Doctoral Candidates of the Ministry of Education of the People&prime ; s Republic of China|
|作者单位||1.Hyogo Coll Med, Dept Publ Hlth, Nishinomiya, Hyogo, Japan|
2.Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Dept Occupat & Environm Hlth Sci, Beijing 100191, Peoples R China
|Wu, Shaowei,Deng, Furong,Wang, Xin,et al. Association of lung function in a panel of young healthy adults with various chemical components of ambient fine particulate air pollution in Beijing, China[J]. ATMOSPHERIC ENVIRONMENT,2013,77:873-884.|
|APA||Wu, Shaowei.,Deng, Furong.,Wang, Xin.,Wei, Hongying.,Shima, Masayuki.,...&Guo, Xinbiao.(2013).Association of lung function in a panel of young healthy adults with various chemical components of ambient fine particulate air pollution in Beijing, China.ATMOSPHERIC ENVIRONMENT,77,873-884.|
|MLA||Wu, Shaowei,et al."Association of lung function in a panel of young healthy adults with various chemical components of ambient fine particulate air pollution in Beijing, China".ATMOSPHERIC ENVIRONMENT 77(2013):873-884.|