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学科主题: 临床医学
题名:
Effects of hydroxycamptothecin on the expression of matrix metalloproteinase-1 (MMP-1), tissue inhibitor of MMP-1, and type I collagen in rats with pulmonary fibrosis
作者: Hu, G. -X.; Yao, S. -T.; Zeng, L. -H.; Peng, Y. -Z.; Zheng, J.
关键词: Pulmonary fibrosis ; Hydroxycamptothecin ; Type I collagen ; Matrix metalloproteinase-1 ; Matrix metalloproteinase inhibitors-1
刊名: GENETICS AND MOLECULAR RESEARCH
发表日期: 2015
DOI: 10.4238/2015.May.4.21
卷: 14, 期:2, 页:4625-4632
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Genetics & Heredity
研究领域[WOS]: Biochemistry & Molecular Biology ; Genetics & Heredity
英文摘要:

The aim of this study was to investigate the effects of hydroxycamptothecin (HCPT) on the expression of matrix metalloproteinase-1 (MMP-1), tissue inhibitor of MMP-1 (TIMP-1), and type I collagen in the lung tissue of rats with pulmonary fibrosis induced by bleomycin A5. We used hematoxylin eosin staining to observe the degree of pulmonary fibrosis in rats; Masson staining, reverse transcription polymerase chain reaction, and immunohistochemistry were used to observe the expression of collagen, MMP-1, and TIMP-1, and type I collagen. The expression of MMP-1 in the model group decreased significantly, while the expression of TIMP-1 and type I collagen significantly increased. After treatment with HCPT, the degree of pulmonary fibrosis and the expression of TIMP-1 and type I collagen decreased in all treatment groups. However, the expression of MMP-1 increased in a dose-dependent manner. Our results showed that HCPT decreased the pulmonary fibrosis induced by bleomycin A5 in rats, and an increase in MMP-1 expression and decrease in the TIMP-1 and type I collagen expression may be the mechanism that regulates the metabolism of the extracellular matrix.

语种: 英语
所属项目编号: 30860230 ; 201401046
项目资助者: National Natural Science Foundation of China ; Health and Family Planning Commission of Shenzhen Municipality
WOS记录号: WOS:000357183700181
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51937
Appears in Collections:北京大学深圳医院_期刊论文

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作者单位: Peking Univ, Shenzhen Hosp, Shenzhen, Peoples R China

Recommended Citation:
Hu, G. -X.,Yao, S. -T.,Zeng, L. -H.,et al. Effects of hydroxycamptothecin on the expression of matrix metalloproteinase-1 (MMP-1), tissue inhibitor of MMP-1, and type I collagen in rats with pulmonary fibrosis[J]. GENETICS AND MOLECULAR RESEARCH,2015,14(2):4625-4632.
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