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Effects of hydroxycamptothecin on the expression of matrix metalloproteinase-1 (MMP-1), tissue inhibitor of MMP-1, and type I collagen in rats with pulmonary fibrosis
Hu, G. -X.; Yao, S. -T.; Zeng, L. -H.; Peng, Y. -Z.; Zheng, J.
关键词Pulmonary Fibrosis Hydroxycamptothecin Type i Collagen Matrix Metalloproteinase-1 Matrix Metalloproteinase Inhibitors-1
刊名GENETICS AND MOLECULAR RESEARCH
2015
DOI10.4238/2015.May.4.21
14期:2页:4625-4632
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Genetics & Heredity
研究领域[WOS]Biochemistry & Molecular Biology ; Genetics & Heredity
英文摘要

The aim of this study was to investigate the effects of hydroxycamptothecin (HCPT) on the expression of matrix metalloproteinase-1 (MMP-1), tissue inhibitor of MMP-1 (TIMP-1), and type I collagen in the lung tissue of rats with pulmonary fibrosis induced by bleomycin A5. We used hematoxylin eosin staining to observe the degree of pulmonary fibrosis in rats; Masson staining, reverse transcription polymerase chain reaction, and immunohistochemistry were used to observe the expression of collagen, MMP-1, and TIMP-1, and type I collagen. The expression of MMP-1 in the model group decreased significantly, while the expression of TIMP-1 and type I collagen significantly increased. After treatment with HCPT, the degree of pulmonary fibrosis and the expression of TIMP-1 and type I collagen decreased in all treatment groups. However, the expression of MMP-1 increased in a dose-dependent manner. Our results showed that HCPT decreased the pulmonary fibrosis induced by bleomycin A5 in rats, and an increase in MMP-1 expression and decrease in the TIMP-1 and type I collagen expression may be the mechanism that regulates the metabolism of the extracellular matrix.

语种英语
WOS记录号WOS:000357183700181
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51937
专题北京大学深圳医院
作者单位Peking Univ, Shenzhen Hosp, Shenzhen, Peoples R China
推荐引用方式
GB/T 7714
Hu, G. -X.,Yao, S. -T.,Zeng, L. -H.,et al. Effects of hydroxycamptothecin on the expression of matrix metalloproteinase-1 (MMP-1), tissue inhibitor of MMP-1, and type I collagen in rats with pulmonary fibrosis[J]. GENETICS AND MOLECULAR RESEARCH,2015,14(2):4625-4632.
APA Hu, G. -X.,Yao, S. -T.,Zeng, L. -H.,Peng, Y. -Z.,&Zheng, J..(2015).Effects of hydroxycamptothecin on the expression of matrix metalloproteinase-1 (MMP-1), tissue inhibitor of MMP-1, and type I collagen in rats with pulmonary fibrosis.GENETICS AND MOLECULAR RESEARCH,14(2),4625-4632.
MLA Hu, G. -X.,et al."Effects of hydroxycamptothecin on the expression of matrix metalloproteinase-1 (MMP-1), tissue inhibitor of MMP-1, and type I collagen in rats with pulmonary fibrosis".GENETICS AND MOLECULAR RESEARCH 14.2(2015):4625-4632.
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