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学科主题: 精神卫生
题名:
Detection of Circulating miRNA Levels in Schizophrenia
作者: Wei, Hui1; Yuan, Yanbo1; Liu, Sha1; Wang, Cheng1; Yang, Fude1; Lu, Zheng1; Wang, Chuanyue1; Deng, Hong1; Zhao, Jinping1; Shen, Yan1; Zhang, Chenyu1; Yu, Xin1; Xu, Qi1
刊名: AMERICAN JOURNAL OF PSYCHIATRY
发表日期: 2015-11-01
DOI: 10.1176/appi.ajp.2015.14030273
卷: 172, 期:11, 页:1141-1147
收录类别: SCI ; SSCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Psychiatry
研究领域[WOS]: Psychiatry
关键词[WOS]: MICRORNA EXPRESSION ; PREFRONTAL CORTEX ; OVARIAN-CANCER ; BIOMARKERS ; MIR-130B ; DISORDER ; SERUM ; PROLIFERATION ; INDIVIDUALS ; REPRESSION
英文摘要:

Objective: Diagnosis of schizophrenia is currently dependent on symptom-based criteria and lacks objective indicators. In this study, the authors investigated whether circulating miRNA can serve as a diagnostic biomarker for schizophrenia.

Methods: Global plasma miRNAs were profiled in a test cohort of 164 schizophrenia patients and 187 control subjects, using Solexa sequencing, TaqMan Low Density Array, and quantitative reverse transcription polymerase chain reaction (qRT-PCR) assays. The captured miRNAs were then validated by qRT-PCR assays in an independent cohort of 400 schizophrenia patients, 213 control subjects, and 162 patients with nonschizophrenia psychiatric disorders; the 400 schizophrenia patients underwent a 12-month follow up study of regular treatment with an atypical antipsychotic (risperidone and aripiprazole)

Results: The global plasma miRNA screening revealed eight miRNAs that were up-regulated in schizophrenia, as revealed by both assay platforms. The qRT-PCR analysis showed the up-regulation of miR-130b and miR-193a-3p in schizophrenia but not in nonschizophrenia disorders.

Conclusions: The up-regulation of miR-130b and miR-193a-3p is a state-independent biomarker for schizophrenia, and these two miRNAs could be used to develop a diagnostic tool for schizophrenia.

语种: 英语
所属项目编号: 2013CB531300 ; 2012CB517902 ; 2014CB542300 ; 201302018 ; 2007BAI17B04 ; 31222031 ; 31430048 ; 81471325 ; 2012S05 ; 2012J09 ; NCET-12-0071
项目资助者: National 973 Projects ; National Key Project of Scientific and Technical Supporting Programs - MOST of China ; National Natural Science Foundation of China ; Fundamental Research Funds for the Central Universities ; Peking Union Medical College Youth Fund
WOS记录号: WOS:000363914700017
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51943
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Beijing Anding Hosp, Beijing, Peoples R China
2.Beijing Hui Long Guan Hosp, Ctr Biol Psychiat, Beijing, Peoples R China
3.Shanghai Mental Hlth Ctr, Shanghai, Peoples R China
4.Chinese Acad Med Sci, Inst Basic Med Sci, Natl Lab Med Mol Biol, Beijing 100730, Peoples R China
5.Chinese Acad Med Sci, Neurosci Ctr, Beijing 100730, Peoples R China
6.Peking Union Med Coll, Beijing 100021, Peoples R China
7.Peking Univ, Hosp 6, Inst Mental Hlth, Key Lab Mental Hlth,Minist Hlth, Beijing 100871, Peoples R China
8.Nanjing Univ, Jiangsu Engn Res Ctr MicroRNA Biol & Biotechnol, State Key Lab Pharmaceut Biotechnol, Sch Life Sci, Nanjing 210008, Jiangsu, Peoples R China
9.Sichuan Univ, West China Hosp, Mental Hlth Ctr, Chengdu 610064, Peoples R China
10.Cent S Univ, Xiangya Hosp 2, Mental Hlth Inst, Changsha, Hunan, Peoples R China

Recommended Citation:
Wei, Hui,Yuan, Yanbo,Liu, Sha,et al. Detection of Circulating miRNA Levels in Schizophrenia[J]. AMERICAN JOURNAL OF PSYCHIATRY,2015,172(11):1141-1147.
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