IR@PKUHSC  > 北京大学精神卫生研究所
学科主题精神卫生
Detection of Circulating miRNA Levels in Schizophrenia
Wei, Hui1; Yuan, Yanbo1; Liu, Sha1; Wang, Cheng1; Yang, Fude1; Lu, Zheng1; Wang, Chuanyue1; Deng, Hong1; Zhao, Jinping1; Shen, Yan1; Zhang, Chenyu1; Yu, Xin1; Xu, Qi1
刊名AMERICAN JOURNAL OF PSYCHIATRY
2015-11-01
DOI10.1176/appi.ajp.2015.14030273
172期:11页:1141-1147
收录类别SCI ; SSCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Psychiatry
研究领域[WOS]Psychiatry
关键词[WOS]MICRORNA EXPRESSION ; PREFRONTAL CORTEX ; OVARIAN-CANCER ; BIOMARKERS ; MIR-130B ; DISORDER ; SERUM ; PROLIFERATION ; INDIVIDUALS ; REPRESSION
英文摘要

Objective: Diagnosis of schizophrenia is currently dependent on symptom-based criteria and lacks objective indicators. In this study, the authors investigated whether circulating miRNA can serve as a diagnostic biomarker for schizophrenia.

Methods: Global plasma miRNAs were profiled in a test cohort of 164 schizophrenia patients and 187 control subjects, using Solexa sequencing, TaqMan Low Density Array, and quantitative reverse transcription polymerase chain reaction (qRT-PCR) assays. The captured miRNAs were then validated by qRT-PCR assays in an independent cohort of 400 schizophrenia patients, 213 control subjects, and 162 patients with nonschizophrenia psychiatric disorders; the 400 schizophrenia patients underwent a 12-month follow up study of regular treatment with an atypical antipsychotic (risperidone and aripiprazole)

Results: The global plasma miRNA screening revealed eight miRNAs that were up-regulated in schizophrenia, as revealed by both assay platforms. The qRT-PCR analysis showed the up-regulation of miR-130b and miR-193a-3p in schizophrenia but not in nonschizophrenia disorders.

Conclusions: The up-regulation of miR-130b and miR-193a-3p is a state-independent biomarker for schizophrenia, and these two miRNAs could be used to develop a diagnostic tool for schizophrenia.

语种英语
WOS记录号WOS:000363914700017
项目编号2013CB531300 ; 2012CB517902 ; 2014CB542300 ; 201302018 ; 2007BAI17B04 ; 31222031 ; 31430048 ; 81471325 ; 2012S05 ; 2012J09 ; NCET-12-0071
资助机构National 973 Projects ; National Key Project of Scientific and Technical Supporting Programs - MOST of China ; National Natural Science Foundation of China ; Fundamental Research Funds for the Central Universities ; Peking Union Medical College Youth Fund
引用统计
被引频次:18[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51943
专题北京大学精神卫生研究所
作者单位1.Beijing Anding Hosp, Beijing, Peoples R China
2.Beijing Hui Long Guan Hosp, Ctr Biol Psychiat, Beijing, Peoples R China
3.Shanghai Mental Hlth Ctr, Shanghai, Peoples R China
4.Chinese Acad Med Sci, Inst Basic Med Sci, Natl Lab Med Mol Biol, Beijing 100730, Peoples R China
5.Chinese Acad Med Sci, Neurosci Ctr, Beijing 100730, Peoples R China
6.Peking Union Med Coll, Beijing 100021, Peoples R China
7.Peking Univ, Hosp 6, Inst Mental Hlth, Key Lab Mental Hlth,Minist Hlth, Beijing 100871, Peoples R China
8.Nanjing Univ, Jiangsu Engn Res Ctr MicroRNA Biol & Biotechnol, State Key Lab Pharmaceut Biotechnol, Sch Life Sci, Nanjing 210008, Jiangsu, Peoples R China
9.Sichuan Univ, West China Hosp, Mental Hlth Ctr, Chengdu 610064, Peoples R China
10.Cent S Univ, Xiangya Hosp 2, Mental Hlth Inst, Changsha, Hunan, Peoples R China
推荐引用方式
GB/T 7714
Wei, Hui,Yuan, Yanbo,Liu, Sha,et al. Detection of Circulating miRNA Levels in Schizophrenia[J]. AMERICAN JOURNAL OF PSYCHIATRY,2015,172(11):1141-1147.
APA Wei, Hui.,Yuan, Yanbo.,Liu, Sha.,Wang, Cheng.,Yang, Fude.,...&Xu, Qi.(2015).Detection of Circulating miRNA Levels in Schizophrenia.AMERICAN JOURNAL OF PSYCHIATRY,172(11),1141-1147.
MLA Wei, Hui,et al."Detection of Circulating miRNA Levels in Schizophrenia".AMERICAN JOURNAL OF PSYCHIATRY 172.11(2015):1141-1147.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Wei, Hui]的文章
[Yuan, Yanbo]的文章
[Liu, Sha]的文章
百度学术
百度学术中相似的文章
[Wei, Hui]的文章
[Yuan, Yanbo]的文章
[Liu, Sha]的文章
必应学术
必应学术中相似的文章
[Wei, Hui]的文章
[Yuan, Yanbo]的文章
[Liu, Sha]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。