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学科主题: 公共卫生
题名:
Interaction of type 2 diabetes mellitus with Chromosome 9p21 rs10757274 polymorphism on the risk of myocardial infarction: a case-control study in Chinese population
作者: Zhang, Liu-wei1; Li, Jian-ping2; Duan, Fang-fang1; Liu, Zhi-ke1; Zhan, Si-yan1; Hu, Yong-hua1; Jiang, Jie2; Zhang, Yan2; Huo, Yong2; Chen, Da-fang1
刊名: BMC CARDIOVASCULAR DISORDERS
发表日期: 2014-11-27
DOI: 10.1186/1471-2261-14-170
卷: 14
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cardiac & Cardiovascular Systems
研究领域[WOS]: Cardiovascular System & Cardiology
关键词[WOS]: CORONARY-ARTERY-DISEASE ; GENOME-WIDE ASSOCIATION ; SINGLE NUCLEOTIDE POLYMORPHISMS ; STROKE STATISTICS-2014 UPDATE ; AMERICAN-HEART-ASSOCIATION ; CARDIOVASCULAR-DISEASE ; SUSCEPTIBILITY LOCUS ; HAN POPULATION ; EXPRESSION ; CELLS
英文摘要:

Background: Myocardial infarction (MI) is a serious complication of Coronary Artery Disease (CAD). Previous studies have identified genetic variants on chromosome 9p21 and 6p24 that are associated with CAD, but further studies need to be conducted to investigate whether these genetic variants are associated with the pathogenesis of MI. We therefore performed this study to assess the association between the risk of MI and SNP rs10757274 on chromosome 9p21 and SNP rs6903956 on chromosome 6p24, and to explore the gene-environment interactions in a Chinese population.

Methods: A hospital-based case-control study, consisting of 502 MI patients and 308 controls, was conducted in a Chinese population. Demographic, behavioral information and clinical characteristics were collected, and genotyping of the two SNPs was performed using single base primer extension genotyping technology. The unconditional logistic regression (ULR) method was adopted to assess the association of the two SNPs with MI risk. Both generalized multifactor dimensionality reduction (GMDR) and ULR methods were applied to explore the effect of gene-environment interactions on the risk of MI.

Results: After adjusting for covariates, it was observed that SNP rs10757274 on chromosome 9p21 was significantly associated with MI. Compared with subjects carrying the AA genotype, subjects carrying the GA or GG genotypes had a higher MI risk (ORa = 1.52, 95% CI: 1.06-2.19, p(a) = 0.0227; ORa = 2.40, 95% CI: 1.51-3.81, p(a) = 0.0002, respectively). Furthermore, a two-factor gene-environment interaction model of CDKN2A/B (rs10757274) and type 2 diabetes mellitus (T2DM) was identified to be the best model by GMDR (p = 0.0107), with a maximum prediction accuracy of 59.18%, and a maximum Cross-validation Consistency of 10/10. By using the ULR method, additive interaction analysis found that the combined effect resulted in T2DM-positive subjects with genotype GG/GA having an MI risk 4.38 times that of T2DM-negative subjects with genotype AA (ORadd = 4.38, 95% CI: 2.56-7.47, p(add) < 0.0001).

Conclusions: These results show that gene polymorphism of CDKN2A/B (rs10757274) is associated with MI risk in a Chinese population. Furthermore, T2DM is likely to have an interaction with CDKN2A/B (rs10757274) that contributes to the risk of MI.

语种: 英语
所属项目编号: 81172768
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000347258900001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51944
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Peking Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Hlth Sci Ctr, Beijing 100191, Peoples R China
2.Peking Univ, Dept Cardiol, Hosp 1, Beijing 100034, Peoples R China

Recommended Citation:
Zhang, Liu-wei,Li, Jian-ping,Duan, Fang-fang,et al. Interaction of type 2 diabetes mellitus with Chromosome 9p21 rs10757274 polymorphism on the risk of myocardial infarction: a case-control study in Chinese population[J]. BMC CARDIOVASCULAR DISORDERS,2014,14.
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