IR@PKUHSC  > 北京大学公共卫生学院
学科主题公共卫生
Interaction of type 2 diabetes mellitus with Chromosome 9p21 rs10757274 polymorphism on the risk of myocardial infarction: a case-control study in Chinese population
Zhang, Liu-wei1; Li, Jian-ping2; Duan, Fang-fang1; Liu, Zhi-ke1; Zhan, Si-yan1; Hu, Yong-hua1; Jiang, Jie2; Zhang, Yan2; Huo, Yong2; Chen, Da-fang1
刊名BMC CARDIOVASCULAR DISORDERS
2014-11-27
DOI10.1186/1471-2261-14-170
14
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cardiac & Cardiovascular Systems
研究领域[WOS]Cardiovascular System & Cardiology
关键词[WOS]CORONARY-ARTERY-DISEASE ; GENOME-WIDE ASSOCIATION ; SINGLE NUCLEOTIDE POLYMORPHISMS ; STROKE STATISTICS-2014 UPDATE ; AMERICAN-HEART-ASSOCIATION ; CARDIOVASCULAR-DISEASE ; SUSCEPTIBILITY LOCUS ; HAN POPULATION ; EXPRESSION ; CELLS
英文摘要

Background: Myocardial infarction (MI) is a serious complication of Coronary Artery Disease (CAD). Previous studies have identified genetic variants on chromosome 9p21 and 6p24 that are associated with CAD, but further studies need to be conducted to investigate whether these genetic variants are associated with the pathogenesis of MI. We therefore performed this study to assess the association between the risk of MI and SNP rs10757274 on chromosome 9p21 and SNP rs6903956 on chromosome 6p24, and to explore the gene-environment interactions in a Chinese population.

Methods: A hospital-based case-control study, consisting of 502 MI patients and 308 controls, was conducted in a Chinese population. Demographic, behavioral information and clinical characteristics were collected, and genotyping of the two SNPs was performed using single base primer extension genotyping technology. The unconditional logistic regression (ULR) method was adopted to assess the association of the two SNPs with MI risk. Both generalized multifactor dimensionality reduction (GMDR) and ULR methods were applied to explore the effect of gene-environment interactions on the risk of MI.

Results: After adjusting for covariates, it was observed that SNP rs10757274 on chromosome 9p21 was significantly associated with MI. Compared with subjects carrying the AA genotype, subjects carrying the GA or GG genotypes had a higher MI risk (ORa = 1.52, 95% CI: 1.06-2.19, p(a) = 0.0227; ORa = 2.40, 95% CI: 1.51-3.81, p(a) = 0.0002, respectively). Furthermore, a two-factor gene-environment interaction model of CDKN2A/B (rs10757274) and type 2 diabetes mellitus (T2DM) was identified to be the best model by GMDR (p = 0.0107), with a maximum prediction accuracy of 59.18%, and a maximum Cross-validation Consistency of 10/10. By using the ULR method, additive interaction analysis found that the combined effect resulted in T2DM-positive subjects with genotype GG/GA having an MI risk 4.38 times that of T2DM-negative subjects with genotype AA (ORadd = 4.38, 95% CI: 2.56-7.47, p(add) < 0.0001).

Conclusions: These results show that gene polymorphism of CDKN2A/B (rs10757274) is associated with MI risk in a Chinese population. Furthermore, T2DM is likely to have an interaction with CDKN2A/B (rs10757274) that contributes to the risk of MI.

语种英语
WOS记录号WOS:000347258900001
项目编号81172768
资助机构National Natural Science Foundation of China
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51944
专题北京大学公共卫生学院
北京大学基础医学院
北京大学第一临床医学院_心血管内科
北京大学临床肿瘤学院_麻醉科
作者单位1.Peking Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Hlth Sci Ctr, Beijing 100191, Peoples R China
2.Peking Univ, Dept Cardiol, Hosp 1, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Liu-wei,Li, Jian-ping,Duan, Fang-fang,et al. Interaction of type 2 diabetes mellitus with Chromosome 9p21 rs10757274 polymorphism on the risk of myocardial infarction: a case-control study in Chinese population[J]. BMC CARDIOVASCULAR DISORDERS,2014,14.
APA Zhang, Liu-wei.,Li, Jian-ping.,Duan, Fang-fang.,Liu, Zhi-ke.,Zhan, Si-yan.,...&Chen, Da-fang.(2014).Interaction of type 2 diabetes mellitus with Chromosome 9p21 rs10757274 polymorphism on the risk of myocardial infarction: a case-control study in Chinese population.BMC CARDIOVASCULAR DISORDERS,14.
MLA Zhang, Liu-wei,et al."Interaction of type 2 diabetes mellitus with Chromosome 9p21 rs10757274 polymorphism on the risk of myocardial infarction: a case-control study in Chinese population".BMC CARDIOVASCULAR DISORDERS 14(2014).
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Interaction of type (303KB)期刊论文出版稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zhang, Liu-wei]的文章
[Li, Jian-ping]的文章
[Duan, Fang-fang]的文章
百度学术
百度学术中相似的文章
[Zhang, Liu-wei]的文章
[Li, Jian-ping]的文章
[Duan, Fang-fang]的文章
必应学术
必应学术中相似的文章
[Zhang, Liu-wei]的文章
[Li, Jian-ping]的文章
[Duan, Fang-fang]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Interaction of type 2 diabetes mellitus with Chromosome 9p21 rs10757274 polymorphism on the risk of myocardial infarction_ a case-control study in Chinese population.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。