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学科主题临床医学
VITREOUS AND PLASMA CONCENTRATIONS OF APELIN AND VASCULAR ENDOTHELIAL GROWTH FACTOR AFTER INTRAVITREAL BEVACIZUMAB IN EYES WITH PROLIFERATIVE DIABETIC RETINOPATHY
Qian, Jing; Lu, Qiang; Tao, Yong; Jiang, Yan-Rong
关键词Apelin Bevacizumab Proliferative Diabetic Retinopathy Vegf
刊名RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
2011
DOI10.1097/IAE.0b013e3181e46ad8
31期:1页:161-168
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Ophthalmology
研究领域[WOS]Ophthalmology
关键词[WOS]BEVACKUMAB AVASTIN ; ANGIOGENIC FACTOR ; HUMAN APJ ; LIGAND ; CELLS ; PHARMACOKINETICS ; MECHANISMS ; INJECTION ; BLOCKADE ; RECEPTOR
英文摘要

Purpose: To evaluate vitreous and plasma concentrations of vascular endothelial growth factor (VEGF) and apelin and to detect the expressions of VEGF and apelin on epiretinal fibrovascular membranes obtained during vitrectomy in eyes with proliferative diabetic retinopathy after intravitreal bevacizumab injection.

Methods: Forty-four eyes of 44 patients affected by active proliferative diabetic retinopathy were investigated. The bevacizumab study group consisted of 20 eyes that received an intravitreal bevacizumab injection (1.25 mg) 7 days before pars plana vitrectomy. The control group included 24 eyes that underwent pars plana vitrectomy without previous intravitreal bevacizumab injection. Using enzyme-linked immunosorbent assay, the concentrations of VEGF and apelin were measured in vitreous and plasma samples. The expressions of VEGF and apelin in the excised epiretinal membranes were examined by fluorescence immunostaining.

Results: Vitreous and plasma concentrations of VEGF were significantly lower in the bevacizumab group than in the control group (P < 0.001 and P = 0.003, respectively), while the vitreous and plasma concentrations of apelin did not vary significantly between the 2 groups (P = 0.62 and P = 0.09, respectively). In the epiretinal fibrovascular membranes of both the groups, a colocalization of the endothelial marker CD31 with the markers for apelin was observed.

Conclusion: Intravitreal bevacizumab injection may lead to a decrease in the intraocular and systemic concentrations of VEGF, suggesting a local and potentially a systemic effect on VEGF but may have no effect on apelin. Apelin may be associated with the development of epiretinal membranes in proliferative diabetic retinopathy and may not directly correlate with VEGF. RETINA 31:161-168, 2011

语种英语
WOS记录号WOS:000285685100022
项目编号30901639
资助机构National Natural Science Foundation of China
引用统计
被引频次:39[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51946
专题北京大学口腔医学院_外科
北京大学第二临床医学院_眼科
作者单位Peking Univ, Dept Ophthalmol, Peoples Hosp, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Qian, Jing,Lu, Qiang,Tao, Yong,et al. VITREOUS AND PLASMA CONCENTRATIONS OF APELIN AND VASCULAR ENDOTHELIAL GROWTH FACTOR AFTER INTRAVITREAL BEVACIZUMAB IN EYES WITH PROLIFERATIVE DIABETIC RETINOPATHY[J]. RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES,2011,31(1):161-168.
APA Qian, Jing,Lu, Qiang,Tao, Yong,&Jiang, Yan-Rong.(2011).VITREOUS AND PLASMA CONCENTRATIONS OF APELIN AND VASCULAR ENDOTHELIAL GROWTH FACTOR AFTER INTRAVITREAL BEVACIZUMAB IN EYES WITH PROLIFERATIVE DIABETIC RETINOPATHY.RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES,31(1),161-168.
MLA Qian, Jing,et al."VITREOUS AND PLASMA CONCENTRATIONS OF APELIN AND VASCULAR ENDOTHELIAL GROWTH FACTOR AFTER INTRAVITREAL BEVACIZUMAB IN EYES WITH PROLIFERATIVE DIABETIC RETINOPATHY".RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES 31.1(2011):161-168.
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