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学科主题临床医学
Effect of repeated freezing-thawing on the Achilles tendon of rabbits
Chen, Lianxu1; Wu, Yanping2; Yu, Jiakuo1; Jiao, Zhaode2; Ao, Yingfang1; Yu, Changlong1; Wang, Jianquan1; Cui, Guoqing1
关键词Repeated Freezing-thawing Achilles Tendon Histology Biomechanics
刊名KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
2011-06-01
DOI10.1007/s00167-010-1278-y
19期:6页:1028-1034
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Orthopedics ; Sport Sciences ; Surgery
研究领域[WOS]Orthopedics ; Sport Sciences ; Surgery
关键词[WOS]ANTERIOR CRUCIATE LIGAMENT ; ARTHROSCOPIC RECONSTRUCTION ; ENDOSCOPIC RECONSTRUCTION ; PATELLAR LIGAMENT ; ALLOGRAFT ; AUTOGRAFT ; RUPTURES ; GRAFTS ; KNEE
英文摘要

The increased use of allograft tissue in the reconstruction of anterior cruciate ligament has brought more focus to the effect of storage and treatment on allograft. The purpose of this study was to observe the effect of histology and biomechanics on Achilles tendon in rabbits through repeated freezing-thawing before allograft tendon transplantation. Rabbit Achilles tendons were harvested and processed according to the manufacture′s protocol of tissue bank, and freezing-thawing was repeated three times (group 1) and ten times (group 2). Those received only one cycle were used as controls. Then, tendons in each group were selected randomly to make for histological observations and biomechanics test. Histological observation showed that the following changes happened as the number of freezing-thawing increased: the arrangement of tendon bundles and collagen fibrils became disordered until ruptured, cells disrupted and apparent gaps appeared between tendon bundle because the formation of ice crystals. There were significant differences between the experimental and control groups in the values of maximum load, energy of maximum load and maximum stress, whereas no significant differences existed in other values such as stiffness, maximum strain, elastic modulus, and energy density. Therefore, repeated freezing-thawing had histological and biomechanical effect on Achilles tendon in rabbits before allograft tendon transplantation. This indicates that cautions should be taken in the repeated freezing-thawing preparation of allograft tendons in clinical application.

语种英语
WOS记录号WOS:000290727400029
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51949
专题北京大学第三临床医学院_运动医学研究所
北京大学第三临床医学院_骨科
作者单位1.Peking Univ, Hosp 3, Inst Sports Med, Beijing 100191, Peoples R China
2.Weifang Yidu Cent Hosp, Dept Orthopaed Surg, Qingzhou 262500, Shandong, Peoples R China
推荐引用方式
GB/T 7714
Chen, Lianxu,Wu, Yanping,Yu, Jiakuo,et al. Effect of repeated freezing-thawing on the Achilles tendon of rabbits[J]. KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY,2011,19(6):1028-1034.
APA Chen, Lianxu.,Wu, Yanping.,Yu, Jiakuo.,Jiao, Zhaode.,Ao, Yingfang.,...&Cui, Guoqing.(2011).Effect of repeated freezing-thawing on the Achilles tendon of rabbits.KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY,19(6),1028-1034.
MLA Chen, Lianxu,et al."Effect of repeated freezing-thawing on the Achilles tendon of rabbits".KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY 19.6(2011):1028-1034.
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