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学科主题: 临床医学
题名:
Botulinum Toxin Type A for the Treatment of Glabellar Lines in Chinese: A Double-Blind, Randomized, Placebo-Controlled Study
作者: Wu, Yan1; Zhao, Guang2; Li, Hengjin3; Zheng, Zhizhong4; Zhong, Shaomin1; Yang, Zhiyong2; Feng, Zheng3; Yang, Qinping4; Zhu, Xuejun1
刊名: DERMATOLOGIC SURGERY
发表日期: 2010
DOI: 10.1111/j.1524-4725.2009.01390.x
卷: 36, 期:1, 页:102-108
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Dermatology ; Surgery
研究领域[WOS]: Dermatology ; Surgery
关键词[WOS]: FROWN LINES ; EXOTOXIN ; RHYTIDS ; EFFICACY ; SAFETY
英文摘要:

BACKGROUND

This is the first well-controlled study of the use of botulinum toxin type A (BoNTA) for glabellar lines in China.

OBJECTIVES

To evaluate the safety and efficacy of BoNTA in the treatment of glabellar lines in Chinese subjects.

MATERIALS AND METHODS

A total of 227 subjects received a single treatment in a 3:1 randomization ratio of BoNTA (20 U):placebo and were observed for 120 days after injection. Effective outcome measures included investigator′s rating of wrinkle severity at maximum frown and rest and subjects′ global assessment and self-perception of age.

RESULTS

A significantly higher responder rate at maximum frown, ranging from 94.1% at day 30 to 52.9% at day 120, was noted in the BoNTA group. The proportion of subjects with none or mild glabellar lines at rest was 66.7% in the BoNTA group at day 30. Most (95.3%) of the subjects treated with BoNTA reported better than 50% improvement at day 30, and self-perception of age was less than chronological age. There were no statistically significant differences in adverse events reported between the two groups (p=.06).

CONCLUSION

A single treatment of 20 U of BoNTA was effective and safe in reducing glabellar lines in Chinese subjects.

GlaxoSmithKline provided funding and study material.

语种: 英语
WOS记录号: WOS:000272892400016
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51951
Appears in Collections:北京大学第一临床医学院_皮肤性病科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Dept Dermatol, Beijing 100034, Peoples R China
2.Gen Hosp AF, Dept Dermatol, Beijing, Peoples R China
3.Chinese Peoples Liberat Army Gen Hosp, Dept Dermatol, Beijing, Peoples R China
4.Fudan Univ, Dept Dermatol, Huashan Hosp, Shanghai 200433, Peoples R China

Recommended Citation:
Wu, Yan,Zhao, Guang,Li, Hengjin,et al. Botulinum Toxin Type A for the Treatment of Glabellar Lines in Chinese: A Double-Blind, Randomized, Placebo-Controlled Study[J]. DERMATOLOGIC SURGERY,2010,36(1):102-108.
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