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Analysis of Insulin Doses of Chinese Type 2 Diabetic Patients with Intensive Insulin Treatment
Cai, Xiaoling; Han, Xueyao; Luo, Yingying; Ji, Linong
刊名PLOS ONE
2012-06-18
DOI10.1371/journal.pone.0038962
7期:6
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]BASAL-BOLUS REGIMEN ; BEDTIME NPH INSULIN ; CONSENSUS STATEMENT ; GLYCEMIC CONTROL ; GLUCOSE CONTROL ; PARALLEL-GROUP ; THERAPY ; GLARGINE ; MANAGEMENT ; DETEMIR
英文摘要

Background: To investigate the daily insulin doses and the ratio of basal insulin to total daily insulin in Chinese type 2 diabetic patients who received basal bolus insulin therapy.

Methodology/Principal Findings: Totally 2480 patients prescribed with pre-meal bolus insulin and bedtime basal insulin were included. The mean daily insulin doses was 38.22 +/- 14.92 IU/day, the mean daily insulin doses per weight was 0.58 +/- 0.22 IU/kg, the mean bolus insulin dose was 0.44 +/- 0.17 IU/kg and the mean basal insulin dose was 0.13 +/- 0.08 IU/kg. The mean basal/total daily insulin ratio (BD/TDD) was 0.23 +/- 0.08. In most patients (47.94%), the BD/TDD was between 0.20 and 0.30. Diabetic duration, BMI, HbA1c, fasting and postprandial blood glucose level were positively associated with daily insulin dose, while age was negatively associated with daily insulin dose. Diabetic duration, BMI, HbA1c, fasting blood glucose level, and using metformin were positively associated with BD/TDD ratio, while age, postprandial C peptide, postprandial blood glucose level and CRE level were negatively associated with BD/TDD ratio.

Conclusions/Significance: The daily insulin doses of intensive treatment in Chinese type 2 diabetic patients was 38.22 IU/day, the mean daily insulin doses per weight was 0.58 IU/kg, mean BD/TDD ratio was 0.23.

语种英语
WOS记录号WOS:000305583300071
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51954
专题北京大学第二临床医学院
作者单位Peking Univ, Dept Endocrinol & Metab, Peoples Hosp, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Cai, Xiaoling,Han, Xueyao,Luo, Yingying,et al. Analysis of Insulin Doses of Chinese Type 2 Diabetic Patients with Intensive Insulin Treatment[J]. PLOS ONE,2012,7(6).
APA Cai, Xiaoling,Han, Xueyao,Luo, Yingying,&Ji, Linong.(2012).Analysis of Insulin Doses of Chinese Type 2 Diabetic Patients with Intensive Insulin Treatment.PLOS ONE,7(6).
MLA Cai, Xiaoling,et al."Analysis of Insulin Doses of Chinese Type 2 Diabetic Patients with Intensive Insulin Treatment".PLOS ONE 7.6(2012).
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