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学科主题: 临床医学
题名:
Analysis of Insulin Doses of Chinese Type 2 Diabetic Patients with Intensive Insulin Treatment
作者: Cai, Xiaoling; Han, Xueyao; Luo, Yingying; Ji, Linong
刊名: PLOS ONE
发表日期: 2012-06-18
DOI: 10.1371/journal.pone.0038962
卷: 7, 期:6
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: BASAL-BOLUS REGIMEN ; BEDTIME NPH INSULIN ; CONSENSUS STATEMENT ; GLYCEMIC CONTROL ; GLUCOSE CONTROL ; PARALLEL-GROUP ; THERAPY ; GLARGINE ; MANAGEMENT ; DETEMIR
英文摘要:

Background: To investigate the daily insulin doses and the ratio of basal insulin to total daily insulin in Chinese type 2 diabetic patients who received basal bolus insulin therapy.

Methodology/Principal Findings: Totally 2480 patients prescribed with pre-meal bolus insulin and bedtime basal insulin were included. The mean daily insulin doses was 38.22 +/- 14.92 IU/day, the mean daily insulin doses per weight was 0.58 +/- 0.22 IU/kg, the mean bolus insulin dose was 0.44 +/- 0.17 IU/kg and the mean basal insulin dose was 0.13 +/- 0.08 IU/kg. The mean basal/total daily insulin ratio (BD/TDD) was 0.23 +/- 0.08. In most patients (47.94%), the BD/TDD was between 0.20 and 0.30. Diabetic duration, BMI, HbA1c, fasting and postprandial blood glucose level were positively associated with daily insulin dose, while age was negatively associated with daily insulin dose. Diabetic duration, BMI, HbA1c, fasting blood glucose level, and using metformin were positively associated with BD/TDD ratio, while age, postprandial C peptide, postprandial blood glucose level and CRE level were negatively associated with BD/TDD ratio.

Conclusions/Significance: The daily insulin doses of intensive treatment in Chinese type 2 diabetic patients was 38.22 IU/day, the mean daily insulin doses per weight was 0.58 IU/kg, mean BD/TDD ratio was 0.23.

语种: 英语
WOS记录号: WOS:000305583300071
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51954
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: Peking Univ, Dept Endocrinol & Metab, Peoples Hosp, Beijing 100871, Peoples R China

Recommended Citation:
Cai, Xiaoling,Han, Xueyao,Luo, Yingying,et al. Analysis of Insulin Doses of Chinese Type 2 Diabetic Patients with Intensive Insulin Treatment[J]. PLOS ONE,2012,7(6).
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