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Improved absorption of salmon calcitonin by ultraflexible liposomes through intranasal delivery
Chen, Ming1; Li, Xin-Ru1; Zhou, Yan-Xia1; Yang, Ke-Wei1; Chen, Xing-Wei1; Deng, Qiu2; Liu, Yan1; Ren, Li Jun3
关键词Ultraflexible Liposome Salmon Calcitonin Nasal Delivery Toxicity Of Nasal Cilia Peptide Hypocalcemic Efficacy
刊名PEPTIDES
2009-07-01
DOI10.1016/j.peptides.2009.03.018
30期:7页:1288-1295
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
研究领域[WOS]Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
关键词[WOS]BIOLOGICAL-ACTIVITY ; NASAL ABSORPTION ; DRUG-DELIVERY ; IN-VITRO ; INSULIN ; MUCOADHESION ; CARRIERS ; RABBITS ; MUCOSA ; VIVO
英文摘要

The objective of this work was to explore the potential of ultraflexible liposomes as carriers for improving the absorption of salmon calcitonin (sCT) through intranasal administration. The average diameters of positively charged ultraflexible liposomes ranged from about 73 to 99 nm, while those of negatively charged ones were 114 and 157.6 nm, respectively. The content of sodium deoxycholate in liposomes markedly affected the size and encapsulated efficiency of liposomes. The absorption of sCT through intranasal administration was evaluated by hypocalcemic efficacy in rats. The total Ca decrease D% of sCT-loaded ultraflexible liposomes with positive and negative charges were significantly bigger than that of sCT solution, while there was no significant difference in the hypocalcemic efficacy between plain liposome and sCT solution. Unexpectedly, the hypocalcemic efficacy of sCT-loaded ultraflexible liposomes with positive charges was not significantly better than those with negative charges. The decrease rate and extent of the serum calcium level for subcutaneous injection of sCT solution were almost equivalent to those for intranasal administration of negatively and positively charged ultraflexible liposomes within the first 2 h, indicating that the ultraflexible liposomes could quickly enhance the penetration of the drug during their residence in the nasal cavity. The results of the toxicity of sCT-loaded ultraflexible liposomes to nasal mucosa demonstrated that the ultraflexible liposomes exerted slight toxicity on the nasal mucosa. On an overall evaluation, the ultraflexible liposomes may be a useful vehicle for intranasal delivery of sCT. (C) 2009 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000268012000012
引用统计
被引频次:20[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51957
专题北京大学药学院_药剂学系
作者单位1.Peking Univ, Dept Pharmaceut, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
2.Beijing Tongren Hosp, Dept Otorhinolaryngol Head & Neck Surg, Beijing 100005, Peoples R China
3.Inst Chem Def, Dept 3, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Chen, Ming,Li, Xin-Ru,Zhou, Yan-Xia,et al. Improved absorption of salmon calcitonin by ultraflexible liposomes through intranasal delivery[J]. PEPTIDES,2009,30(7):1288-1295.
APA Chen, Ming.,Li, Xin-Ru.,Zhou, Yan-Xia.,Yang, Ke-Wei.,Chen, Xing-Wei.,...&Ren, Li Jun.(2009).Improved absorption of salmon calcitonin by ultraflexible liposomes through intranasal delivery.PEPTIDES,30(7),1288-1295.
MLA Chen, Ming,et al."Improved absorption of salmon calcitonin by ultraflexible liposomes through intranasal delivery".PEPTIDES 30.7(2009):1288-1295.
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