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学科主题: 药学
题名:
Improved absorption of salmon calcitonin by ultraflexible liposomes through intranasal delivery
作者: Chen, Ming1; Li, Xin-Ru1; Zhou, Yan-Xia1; Yang, Ke-Wei1; Chen, Xing-Wei1; Deng, Qiu2; Liu, Yan1; Ren, Li Jun3
关键词: Ultraflexible liposome ; Salmon calcitonin ; Nasal delivery ; Toxicity of nasal cilia ; Peptide ; Hypocalcemic efficacy
刊名: PEPTIDES
发表日期: 2009-07-01
DOI: 10.1016/j.peptides.2009.03.018
卷: 30, 期:7, 页:1288-1295
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
研究领域[WOS]: Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
关键词[WOS]: BIOLOGICAL-ACTIVITY ; NASAL ABSORPTION ; DRUG-DELIVERY ; IN-VITRO ; INSULIN ; MUCOADHESION ; CARRIERS ; RABBITS ; MUCOSA ; VIVO
英文摘要:

The objective of this work was to explore the potential of ultraflexible liposomes as carriers for improving the absorption of salmon calcitonin (sCT) through intranasal administration. The average diameters of positively charged ultraflexible liposomes ranged from about 73 to 99 nm, while those of negatively charged ones were 114 and 157.6 nm, respectively. The content of sodium deoxycholate in liposomes markedly affected the size and encapsulated efficiency of liposomes. The absorption of sCT through intranasal administration was evaluated by hypocalcemic efficacy in rats. The total Ca decrease D% of sCT-loaded ultraflexible liposomes with positive and negative charges were significantly bigger than that of sCT solution, while there was no significant difference in the hypocalcemic efficacy between plain liposome and sCT solution. Unexpectedly, the hypocalcemic efficacy of sCT-loaded ultraflexible liposomes with positive charges was not significantly better than those with negative charges. The decrease rate and extent of the serum calcium level for subcutaneous injection of sCT solution were almost equivalent to those for intranasal administration of negatively and positively charged ultraflexible liposomes within the first 2 h, indicating that the ultraflexible liposomes could quickly enhance the penetration of the drug during their residence in the nasal cavity. The results of the toxicity of sCT-loaded ultraflexible liposomes to nasal mucosa demonstrated that the ultraflexible liposomes exerted slight toxicity on the nasal mucosa. On an overall evaluation, the ultraflexible liposomes may be a useful vehicle for intranasal delivery of sCT. (C) 2009 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000268012000012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51957
Appears in Collections:北京大学药学院_药剂学系_期刊论文

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作者单位: 1.Peking Univ, Dept Pharmaceut, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
2.Beijing Tongren Hosp, Dept Otorhinolaryngol Head & Neck Surg, Beijing 100005, Peoples R China
3.Inst Chem Def, Dept 3, Beijing 100191, Peoples R China

Recommended Citation:
Chen, Ming,Li, Xin-Ru,Zhou, Yan-Xia,et al. Improved absorption of salmon calcitonin by ultraflexible liposomes through intranasal delivery[J]. PEPTIDES,2009,30(7):1288-1295.
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