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学科主题: 临床医学
题名:
Recent advances in andrology-related stem cell research
作者: Lin, Ching-Shwun1; Xin, Zhong-Cheng2; Deng, Chun-Hua3; Ning, Hongxiu1; Lin, Guiting1; Lue, Tom F.1
关键词: stem cells ; bone marrow stem cells ; adipose tissue-derived stem cells ; erectile dysfunction ; male infertility
刊名: ASIAN JOURNAL OF ANDROLOGY
发表日期: 2008-03-01
DOI: 10.1111/j.1745-7262.2008.00389.x
卷: 10, 期:2, 页:171-175
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Andrology ; Urology & Nephrology
研究领域[WOS]: Endocrinology & Metabolism ; Urology & Nephrology
关键词[WOS]: HUMAN ADIPOSE-TISSUE ; MESENCHYMAL STROMAL CELLS ; SMOOTH-MUSCLE-CELLS ; VERSUS-HOST-DISEASE ; GERM-CELLS ; PROGENITOR CELLS ; SALVAGE THERAPY ; IN-VITRO ; DIFFERENTIATION ; LIPOSUCTION
英文摘要:

Stem cells hold great promise for regenerative medicine because of their ability to self-renew and to differentiate into various cell types. Although embryonic stem cells (BSC) have greater differentiation potential than adult stem cells, the former is lagging in reaching clinical applications because of ethical concerns and governmental restrictions. Bone marrow stem cells (BMSC) are the best- studied adult stem cells (ASC) and have the potential to treat a wide variety of diseases, including erectile dysfunction (ED) and male infertility. More recently discovered adipose tissue-derived stem cells (ADSC) are virtually identical to bone marrow stem cells in differentiation and therapeutic potential, but are easier and safer to obtain, can be harvested in larger quantities, and have the associated benefit of reducing obesity. Therefore, ADSC appear to be a better choice for future clinical applications. We have previously shown that ESC could restore the erectile function of neurogenic ED in rats, and we now have evidence that ADSC could do so as well. We are also investigating whether ADSC can differentiate into Leydig, Sertoli and male germ cells. The eventual goal is to use ADSC to treat male infertility and testosterone deficiency.

语种: 英语
WOS记录号: WOS:000253604100001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51961
Appears in Collections:北京大学第一临床医学院_男科中心_期刊论文

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作者单位: 1.Univ Calif San Francisco, Sch Med, Dept Urol, Knuppe Mol Urol Lab, San Francisco, CA 94143 USA
2.Peking Univ First Hosp, Androl Ctr, Beijing 100009, Peoples R China
3.Sun Yat Sen Univ, Affairs Hosp 1, Dept Urol, Guangzhou 510080, Peoples R China

Recommended Citation:
Lin, Ching-Shwun,Xin, Zhong-Cheng,Deng, Chun-Hua,et al. Recent advances in andrology-related stem cell research[J]. ASIAN JOURNAL OF ANDROLOGY,2008,10(2):171-175.
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