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学科主题: 临床医学
题名:
Therapeutic Retrobulbar Inhibition of STAT3 Protects Ischemic Retina Ganglion Cells
作者: Wong, Mansin1; Li, Ying1; Li, Shang2; Zhang, Shaodan1,3; Li, Weiyi1,4; Zhang, Pei1; Chen, Chaoran5; Barnstable, Colin J.6; Zhang, Samuel S.6; Zhang, Chun1; Huang, Ping1,7
关键词: Optic nerve head ; Astrocyte ; Astrogliosis ; JAK/STAT3 pathway ; Neuroprotection ; Glaucoma
刊名: MOLECULAR NEUROBIOLOGY
发表日期: 2015-12-01
DOI: 10.1007/s12035-014-8945-9
卷: 52, 期:3, 页:1364-1377
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: OPTIC-NERVE HEAD ; INTRAOCULAR-PRESSURE ELEVATION ; SPINAL-CORD-INJURY ; GROWTH-FACTOR ; RAT MODEL ; EXPERIMENTAL GLAUCOMA ; REACTIVE ASTROCYTES ; CEREBRAL-ISCHEMIA ; AXONAL-TRANSPORT ; JAK/STAT PATHWAY
英文摘要:

Astrocytes play an important role in the pathogenesis of glaucoma. Abnormal activation and/or proliferation of astrocytes, termed astrogliosis, have been observed during optic nerve degeneration. Our previous study identified signal transducer and activator of transcription 3 (STAT3) signaling as an important regulator of astrogliosis in the optic nerve in a rat transient ischemia/reperfusion model. In this study, we used pharmacological inhibition of STAT3 activation in the same model to assess whether it could attenuate reactive astrogliosis and to observe its influence on optic nerve damage and retinal ganglion cell (RGC) damage. Our findings show that retrobulbar inhibition of STAT3 in optic nerve head astrocytes leads to (a) increased nerve fiber bundle survival in the optic nerve, (b) increased nerve fiber bundle and RGC survival in the retina, (c) decreased astrocyte reactivation in the optic nerve (d) decreased remodeling of astrocytes in the optic nerve, and (e) no influence of astrocyte reactivation inside the retina. Taken together, the Janus kinase/STAT3 pathway contributes to astrocyte reactivation in the optic nerve, which plays a pivotal role in neurodegeneration after transient ischemia/reperfusion in vivo. Inhibition of this pathway provides a potential therapeutic strategy for the treatment of glaucomatous neuropathy, and could extend to other neurodegenerative diseases.

语种: 英语
所属项目编号: 81300756 ; 7132219
项目资助者: Chinese State Natural and Science Foundation ; Beijing Natural Science Foundation
WOS记录号: WOS:000361903400024
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51964
Appears in Collections:北京大学第三临床医学院_眼科_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Ctr Eye, Dept Ophthalmol, Beijing 100191, Peoples R China
2.Capital Med Univ, Beijing YouAn Hosp, Dept Ophthalmol, Beijing 100191, Peoples R China
3.4th Peoples Hosp Shenyang, Shenyang Inst Ophthalmol, Dept Ophthalmol, Shenyang 110031, Liaoning, Peoples R China
4.Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Dept Ophthalmol, Shanghai 200127, Peoples R China
5.Univ Birmingham, Sch Psychol, Birmingham B15 2TT, W Midlands, England
6.Penn State Univ, Dept Neural & Behav Sci, Hershey, PA 17033 USA
7.Peking Univ, Hosp 3, Dept Ophthalmol, Beijing 100191, Peoples R China

Recommended Citation:
Wong, Mansin,Li, Ying,Li, Shang,et al. Therapeutic Retrobulbar Inhibition of STAT3 Protects Ischemic Retina Ganglion Cells[J]. MOLECULAR NEUROBIOLOGY,2015,52(3):1364-1377.
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