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学科主题: 临床医学
题名:
Autoantibodies against glomerular mesangial cells and their target antigens in lupus nephritis
作者: Chen, M1; Wang, YY1; Zhao, MH1; Zhang, YK1; Wang, HY1
关键词: autoantibodies ; lupus nephritis ; mesangial cell
刊名: RENAL FAILURE
发表日期: 2005
DOI: 10.1080/08860220500198151
卷: 27, 期:5, 页:507-513
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES ; DISEASE-ACTIVITY ; ERYTHEMATOSUS ; NEPHROPATHY ; SPECIFICITY
英文摘要:

Mesangial proliferation and deposition of immunoglobulins and complement components within glomerular mesangium was one of the important pathological features of lupus nephritis. Autoantibodies against human mesangial cells could be detected in the sera of patients with IgA nephropathy (IgAN) and Henoch-Schoenlein nephritis. We speculated that autoantibodies against human glomerular mesangial cells might play a role in the development of lupus nephritis. Objective. To screen autoantibodies against human glomerular mesangial cells in sera from patients with lupus nephritis and to identify their target antigens. Methods. Sera were collected from 96 patients with lupus nephritis as well as 25 patients with IgAN and 20 patients with idiopathic membranous nephropathy (IMN). Cell lysates of in vitro cultured human glomerular mesangial cells were used as antigens in Western-blot analysis to detect autoantibodies against human mesangial cells in sera from patients with lupus nephritis as well as IgAN and IMN. The clinical and pathological significance of the autoantibodies were further investigated. Results. Autoantibodies against human mesangial cells could be detected in 94/96 (97.9%) of the sera from patients with lupus nephritis in Western-blot analysis. Twelve protein bands could be blotted by the sera from patients with lupus nephritis. The prevalence of autoantibodies against human mesangial cells in IgAN was 14/25 (56.0%) and only seven protein bands could be blotted. Five autoantibodies (anti-18, 24, 36, 46, and 91 kD) could be detected only in sera from patients with lupus nephritis. In patients with lupus nephritis, some autoantibodies might have some relationship with gender, hematuria, ANA, anti-dsDNA or anti-ENA antibodies. Conclusions. There are autoantibodies directly against heterogeneous antigens of human glomerular mesangial cells in sera from patients with lupus nephritis, and some of them might be associated with different clinical manifestations.

语种: 英语
WOS记录号: WOS:000231674500003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51971
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 1.Peking Univ, First Hosp, Div Renal, Beijing 100034, Peoples R China
2.Peking Univ, First Hosp, Inst Nephrol, Beijing 100034, Peoples R China

Recommended Citation:
Chen, M,Wang, YY,Zhao, MH,et al. Autoantibodies against glomerular mesangial cells and their target antigens in lupus nephritis[J]. RENAL FAILURE,2005,27(5):507-513.
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