|Influence of Valsartan on myocardial apoptosis in spontaneously hypertensive rats|
|Li, WM1; Sun, NL1; Liu, W1; Chen, YY1; Yu, YZ1|
|关键词||Cardiac Hypertrophy Heart Failure Apoptosis Tunel Valsartan|
|刊名||CHINESE MEDICAL JOURNAL|
|WOS标题词||Science & Technology|
|类目[WOS]||Medicine, General & Internal|
|研究领域[WOS]||General & Internal Medicine|
Objective To explore the pathogenic changes of myocardial apoptosis in heart hypertrophy during hypertension and evaluate the anti-apoptosis effect of Valsartan.
Methods Thirty spontaneously hypertensive rats (SHRs) were divided into two groups: 15 treated with Valsartan (20 mg.kg(-1).d(-1)) (SHR + Valsartan group), the others with placebo (SHR + placebo group), with 15 normal Wistar rats as control. Systolic blood pressure was measured by the tail-cuff method. The observation period was from 8 to 16 weeks of age. Cardiac apoptosis was evaluated by a Terminal Deoxynucleotidyl Transferase- Mediated dUTP-biotin Nick End Labeling (TUNEL) assay.
Results Mean blood pressure values were 127 +/- 2 mm Hg in controls, 163 6 mm Hg in the SHR + Valsartan group and 193 7 mm Hg in the SHR + placebo group at 16 weeks of age, whereas the blood pressure in 8-week-old SHR and Wistar rats were 175 +/- 3 mm Hg and 125 +/- 5 mm Hg, respectively. The ratio of the heart weight over body weight declined in Wistar (3.07 +/- 0.03 mg/g) and SHR + Valsartan groups (3.22 +/- 0.19 mg/g) compared with the SHR + placebo group (4.02 +/- 0.31 mg/g) ( P < 0.05). The density of TUNEL-positive cells in Wistar and SHR Valsartan groups was 23.3 +/- 3.3 nuclei/HPF and 35.0 +/- 1.3 nuclei/HPF, both of which were significantly less than that of the SHR + placebo group (116.7 +/- 11.3 nuclei/HPF).
Conclusions In response to chronic pressure overload, cardiomyocyte-specific apoptosis contributes to the transition from compensatory hypertrophy to decompensation. Apoptosis may be effectively inhibited by Valsartan in the early stage of hypertension.
|作者单位||1.Harbin Med Coll, Affiliated Hosp 1, Dept Cardiol, Harbin 150001, Peoples R China|
2.Beijing Med Univ, Dept Cardiol, Peoples Hosp, Beijing 100044, Peoples R China
|Li, WM,Sun, NL,Liu, W,et al. Influence of Valsartan on myocardial apoptosis in spontaneously hypertensive rats[J]. CHINESE MEDICAL JOURNAL,2002,115(3):364-366.|
|APA||Li, WM,Sun, NL,Liu, W,Chen, YY,&Yu, YZ.(2002).Influence of Valsartan on myocardial apoptosis in spontaneously hypertensive rats.CHINESE MEDICAL JOURNAL,115(3),364-366.|
|MLA||Li, WM,et al."Influence of Valsartan on myocardial apoptosis in spontaneously hypertensive rats".CHINESE MEDICAL JOURNAL 115.3(2002):364-366.|