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学科主题: 临床医学
题名:
Influence of Valsartan on myocardial apoptosis in spontaneously hypertensive rats
作者: Li, WM1; Sun, NL1; Liu, W1; Chen, YY1; Yu, YZ1
关键词: cardiac hypertrophy ; heart failure ; apoptosis ; TUNEL ; Valsartan
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2002-03-01
卷: 115, 期:3, 页:364-366
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: CELL
英文摘要:

Objective To explore the pathogenic changes of myocardial apoptosis in heart hypertrophy during hypertension and evaluate the anti-apoptosis effect of Valsartan.

Methods Thirty spontaneously hypertensive rats (SHRs) were divided into two groups: 15 treated with Valsartan (20 mg.kg(-1).d(-1)) (SHR + Valsartan group), the others with placebo (SHR + placebo group), with 15 normal Wistar rats as control. Systolic blood pressure was measured by the tail-cuff method. The observation period was from 8 to 16 weeks of age. Cardiac apoptosis was evaluated by a Terminal Deoxynucleotidyl Transferase- Mediated dUTP-biotin Nick End Labeling (TUNEL) assay.

Results Mean blood pressure values were 127 +/- 2 mm Hg in controls, 163 6 mm Hg in the SHR + Valsartan group and 193 7 mm Hg in the SHR + placebo group at 16 weeks of age, whereas the blood pressure in 8-week-old SHR and Wistar rats were 175 +/- 3 mm Hg and 125 +/- 5 mm Hg, respectively. The ratio of the heart weight over body weight declined in Wistar (3.07 +/- 0.03 mg/g) and SHR + Valsartan groups (3.22 +/- 0.19 mg/g) compared with the SHR + placebo group (4.02 +/- 0.31 mg/g) ( P < 0.05). The density of TUNEL-positive cells in Wistar and SHR Valsartan groups was 23.3 +/- 3.3 nuclei/HPF and 35.0 +/- 1.3 nuclei/HPF, both of which were significantly less than that of the SHR + placebo group (116.7 +/- 11.3 nuclei/HPF).

Conclusions In response to chronic pressure overload, cardiomyocyte-specific apoptosis contributes to the transition from compensatory hypertrophy to decompensation. Apoptosis may be effectively inhibited by Valsartan in the early stage of hypertension.

语种: 英语
WOS记录号: WOS:000174717800011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51974
Appears in Collections:北京大学第二临床医学院_心血管内科_期刊论文

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作者单位: 1.Harbin Med Coll, Affiliated Hosp 1, Dept Cardiol, Harbin 150001, Peoples R China
2.Beijing Med Univ, Dept Cardiol, Peoples Hosp, Beijing 100044, Peoples R China

Recommended Citation:
Li, WM,Sun, NL,Liu, W,et al. Influence of Valsartan on myocardial apoptosis in spontaneously hypertensive rats[J]. CHINESE MEDICAL JOURNAL,2002,115(3):364-366.
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