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学科主题: 药物依赖
题名:
Association between TNF-alpha promoter-308A/G polymorphism and tardive dyskinesia in Chinese Han patients with schizophrenia
作者: Wang, Fan1,2; Fan, Hongzhen2; Sun, Hongqiang2; Yang, Fude2; Luo, Yixiao1; Liu, Haibo2; Kosten, Thomas R.3; Lu, Lin1; Zhang, Xiang Yang2,3
关键词: Association ; Polymorphism ; Schizophrenia ; Tardive dyskinesia ; Tumor necrosis factor-alpha
刊名: PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
发表日期: 2012-04-27
DOI: 10.1016/j.pnpbp.2011.12.007
卷: 37, 期:1, 页:106-110
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Clinical Neurology ; Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
研究领域[WOS]: Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
关键词[WOS]: NECROSIS-FACTOR-ALPHA ; GENE POLYMORPHISM ; NO ASSOCIATION ; POPULATION ; RISK ; CLOZAPINE ; DRUG ; INTERLEUKIN-2 ; ANTIBODIES ; DISORDERS
英文摘要:

Objective: Previous studies have indicated that the immune may be involved in the pathogenesis of tardive dyskinesia (TD). Some genetic polymorphisms in the human leukocyte antigen (HLA) I and II regions have been associated with TD, and the tumor necrosis factor-alpha (TNF-alpha) gene is located in the HLA III region. TNF-alpha levels in the striatum significantly increased in haloperidol-induced TD in rats. The TNF-alpha gene -308A/G single nucleotide polymorphism (SNP) has been shown to directly influence TNF-alpha expression. The genetic association between the TNF-alpha gene -308A/G SNP and TD is unclear. The present study investigated whether this variation is associated with clinical phenotypes and TD in schizophrenia in a genetically homogeneous northern Chinese Han population.

Methods: We genotyped the TNF-alpha gene -308A/G SNP in patients with schizophrenia with TO (n=350) and without TD (n=410). The Abnormal Involuntary Movement Scale (AIMS) and Positive and Negative Syndrome Scale (PANSS) were used to assess the severity of TD and psychopathology of schizophrenia, respectively.

Results: The allele and genotype frequencies did not significantly differ between patients with schizophrenia with and without TD (p>0.05). No significant difference was found in the total AIMS score between the genotypes (p>0.05). However, the PANSS negative symptom subscore was associated with risk for TD (p=0.004), and a significant difference was found in total AIMS score between the genotypes in TD patients (p=0.013).

Conclusion: The TNF-alpha gene -308A/G polymorphism does not appear to play a major role in the susceptibility to TD in patients with schizophrenia in a northern Chinese Han population. However this polymorphism may play a role in the TD severity. (c) 2011 Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: U01-MH79639 ; K05-DA0454 ; P50-DA18827 ; 7072035 ; 03T-459 ; 05T-726
项目资助者: United States National Institute of Health ; Department of Veterans Affairs, VISN 16, Mental Illness Research, Education and Clinical Center (MIRECC) ; Beijing Municipal Natural Science Foundation ; Stanley Medical Research Institute
WOS记录号: WOS:000302672300015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51975
Appears in Collections:中国药物依赖性研究所_期刊论文

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作者单位: 1.Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China
2.Beijing Hui Long Guan Hosp, Psychiat Res Ctr, Beijing 100096, Peoples R China
3.Baylor Coll Med, Menninger Dept Psychiat & Behav Sci, Houston, TX 77030 USA

Recommended Citation:
Wang, Fan,Fan, Hongzhen,Sun, Hongqiang,et al. Association between TNF-alpha promoter-308A/G polymorphism and tardive dyskinesia in Chinese Han patients with schizophrenia[J]. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY,2012,37(1):106-110.
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