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学科主题: 药学
题名:
Multifunctional liposomes loaded with paclitaxel and artemether for treatment of invasive brain glioma
作者: Li, Xiu-Ying1; Zhao, Yao1; Sun, Meng-Ge1; Shi, Ji-Feng1; Ju, Rui-Jun1; Zhang, Cheng-Xiang1; Li, Xue-Tao1; Zhao, Wei-Yu1; Mu, Li-Min1; Zeng, Fan1; Lou, Jin-Ning2; Lu, Wan-Liang1
关键词: Functional targeting liposomes ; Brain glioma ; Cancer stem cells ; VM channels ; Anticancer efficacy
刊名: BIOMATERIALS
发表日期: 2014-07-01
DOI: 10.1016/j.biomaterials.2014.03.049
卷: 35, 期:21, 页:5591-5604
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Engineering, Biomedical ; Materials Science, Biomaterials
研究领域[WOS]: Engineering ; Materials Science
关键词[WOS]: CANCER STEM-CELLS ; RESISTANT LUNG-CANCER ; BREAST-CANCER ; VASCULOGENIC MIMICRY ; TUMOR ; BLOOD ; DELIVERY ; BARRIER ; ANGIOGENESIS ; EXPRESSION
英文摘要:

Invasive brain glioma is the most lethal type of cancer and is highly infiltrating. This leads to an extremely poor prognosis and makes complete surgical removal of the tumor virtually impossible. Non-penetration of therapeutic drugs across the blood-brain barrier (BBB), brain cancer stem cells (CSCs), and brain cancer vasculogenic mimicry (VM) results in relapse after surgical and radio therapy. We developed a functional targeting chemotherapy for transporting drugs across the BBB, destroying VM channels, and eliminating CSCs and cancer cells in the brain. The studies were undertaken on brain glioma cells in vitro and in brain glioma-bearing rats. Using paclitaxel as the anticancer drug and artemether as the regulator of apoptosis and inhibitor of VM channels, a kind of functional targeting paclitaxel plus artemether liposomes was developed by modifying two new functional materials: a mannose-vitamin E derivative conjugate (MAN-TPGS(1000)) and a dequalinium-lipid derivative conjugate (DQA-PEG(2000)-DSPE). The transport mechanism across the BBB was associated with receptor-mediated endocytosis by MAN-TPGS(1000) conjugate via glucose transporters and adsorptive-mediated endocytosis by DQA-PEG(2000)-DSPE conjugate via electric charge-based interactions. The efficacy was related to the destruction of VM channels by regulating VM indicators, as well as the induction of apoptosis in brain cancer cells and CSCs by activating apoptotic enzymes and pro-apoptotic proteins and inhibiting antiapoptotic proteins. These data suggest that the chemotherapy using functional targeting paclitaxel plus artemether liposomes could provide a new strategy for treating invasive brain glioma. (C) 2014 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 2013CB932501 ; 7131009 ; 81373343 ; BMU20110263
项目资助者: National Basic Research Program of China (973 program) ; Beijing Natural Science Foundation ; National Natural Science Foundation of China ; Innovation Team of Ministry of Education
WOS记录号: WOS:000336346000017
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51976
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.China Japan Friendship Hosp, Inst Clin Med Sci, Beijing, Peoples R China

Recommended Citation:
Li, Xiu-Ying,Zhao, Yao,Sun, Meng-Ge,et al. Multifunctional liposomes loaded with paclitaxel and artemether for treatment of invasive brain glioma[J]. BIOMATERIALS,2014,35(21):5591-5604.
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