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Multifunctional liposomes loaded with paclitaxel and artemether for treatment of invasive brain glioma
Li, Xiu-Ying1; Zhao, Yao1; Sun, Meng-Ge1; Shi, Ji-Feng1; Ju, Rui-Jun1; Zhang, Cheng-Xiang1; Li, Xue-Tao1; Zhao, Wei-Yu1; Mu, Li-Min1; Zeng, Fan1; Lou, Jin-Ning2; Lu, Wan-Liang1
关键词Functional Targeting Liposomes Brain Glioma Cancer Stem Cells Vm Channels Anticancer Efficacy
刊名BIOMATERIALS
2014-07-01
DOI10.1016/j.biomaterials.2014.03.049
35期:21页:5591-5604
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Engineering, Biomedical ; Materials Science, Biomaterials
研究领域[WOS]Engineering ; Materials Science
关键词[WOS]CANCER STEM-CELLS ; RESISTANT LUNG-CANCER ; BREAST-CANCER ; VASCULOGENIC MIMICRY ; TUMOR ; BLOOD ; DELIVERY ; BARRIER ; ANGIOGENESIS ; EXPRESSION
英文摘要

Invasive brain glioma is the most lethal type of cancer and is highly infiltrating. This leads to an extremely poor prognosis and makes complete surgical removal of the tumor virtually impossible. Non-penetration of therapeutic drugs across the blood-brain barrier (BBB), brain cancer stem cells (CSCs), and brain cancer vasculogenic mimicry (VM) results in relapse after surgical and radio therapy. We developed a functional targeting chemotherapy for transporting drugs across the BBB, destroying VM channels, and eliminating CSCs and cancer cells in the brain. The studies were undertaken on brain glioma cells in vitro and in brain glioma-bearing rats. Using paclitaxel as the anticancer drug and artemether as the regulator of apoptosis and inhibitor of VM channels, a kind of functional targeting paclitaxel plus artemether liposomes was developed by modifying two new functional materials: a mannose-vitamin E derivative conjugate (MAN-TPGS(1000)) and a dequalinium-lipid derivative conjugate (DQA-PEG(2000)-DSPE). The transport mechanism across the BBB was associated with receptor-mediated endocytosis by MAN-TPGS(1000) conjugate via glucose transporters and adsorptive-mediated endocytosis by DQA-PEG(2000)-DSPE conjugate via electric charge-based interactions. The efficacy was related to the destruction of VM channels by regulating VM indicators, as well as the induction of apoptosis in brain cancer cells and CSCs by activating apoptotic enzymes and pro-apoptotic proteins and inhibiting antiapoptotic proteins. These data suggest that the chemotherapy using functional targeting paclitaxel plus artemether liposomes could provide a new strategy for treating invasive brain glioma. (C) 2014 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000336346000017
项目编号2013CB932501 ; 7131009 ; 81373343 ; BMU20110263
资助机构National Basic Research Program of China (973 program) ; Beijing Natural Science Foundation ; National Natural Science Foundation of China ; Innovation Team of Ministry of Education
引用统计
被引频次:65[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51976
专题北京大学药学院
作者单位1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.China Japan Friendship Hosp, Inst Clin Med Sci, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Li, Xiu-Ying,Zhao, Yao,Sun, Meng-Ge,et al. Multifunctional liposomes loaded with paclitaxel and artemether for treatment of invasive brain glioma[J]. BIOMATERIALS,2014,35(21):5591-5604.
APA Li, Xiu-Ying.,Zhao, Yao.,Sun, Meng-Ge.,Shi, Ji-Feng.,Ju, Rui-Jun.,...&Lu, Wan-Liang.(2014).Multifunctional liposomes loaded with paclitaxel and artemether for treatment of invasive brain glioma.BIOMATERIALS,35(21),5591-5604.
MLA Li, Xiu-Ying,et al."Multifunctional liposomes loaded with paclitaxel and artemether for treatment of invasive brain glioma".BIOMATERIALS 35.21(2014):5591-5604.
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