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学科主题: 口腔医学
题名:
Dentonin, a fragment of MEPE, enhanced dental pulp stem cell proliferation
作者: Liu, H1; Li, W1; Gao, C1; Kumagai, Y1; Blacher, RW1; DenBesten, PK1
关键词: MEPE ; dental pulp stem cells ; proliferation ; Dentonin ; AC-100
刊名: JOURNAL OF DENTAL RESEARCH
发表日期: 2004-06-01
卷: 83, 期:6, 页:496-499
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Dentistry, Oral Surgery & Medicine
研究领域[WOS]: Dentistry, Oral Surgery & Medicine
关键词[WOS]: EXTRACELLULAR-MATRIX PROTEINS ; RHEUMATOID-ARTHRITIS ; BONE-FORMATION ; IN-VITRO ; GENE ; OSTEOMALACIA ; EXPRESSION ; INTEGRINS ; BINDING ; VIVO
英文摘要:

Matrix extracellular phosphoglycoprotein ( MEPE) is a SIBLING protein, found in bone and dental tissues. The purpose of this study was to determine whether a 23-amino-acid peptide derived from MEPE ( Dentonin or AC-100) could stimulate dental pulp stem cell ( DPSC) proliferation and/or differentiation. DPSCs were isolated from erupted human molars, and the mitogenic potential of Dentonin in DPSCs was measured by BrdU immunoassay and cell-cycle gene SuperArray. Differentiation of DPSCs with Dentonin was characterized by Western blot and by osteogenesis gene SuperArray. Dentonin enhanced DPSC proliferation by down-regulating P16, accompanied by up-regulation of ubiquitin protein ligase E3A and human ubiquitin-related protein SUMO-1. Enhanced cell proliferation required intact RGD and SGDG motifs in the peptide. This study shows that Dentonin can promote DPSC proliferation, with a potential role in pulp repair. Further studies are required to determine the usefulness of this material in vivo.

语种: 英语
WOS记录号: WOS:000226597900012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51977
Appears in Collections:北京大学口腔医学院_期刊论文

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作者单位: 1.Peking Univ, Sch Stomatol, Beijing 100871, Peoples R China
2.Acologix, Emeryville, CA USA
3.Univ Calif San Francisco, San Francisco, CA 94143 USA

Recommended Citation:
Liu, H,Li, W,Gao, C,et al. Dentonin, a fragment of MEPE, enhanced dental pulp stem cell proliferation[J]. JOURNAL OF DENTAL RESEARCH,2004,83(6):496-499.
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