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学科主题: 临床医学
题名:
Three-day lansoprazole quadruple therapy for Helicobacter pylori-positive duodenal ulcers: a randomized controlled study
作者: Wong, BCY1; Wang, WH1; Wong, WM1; Lau, GKK1; Fung, FMY1; Kung, NNS1; Chu, KM1; Lai, KC1; Hu, WHC1; Hu, FL1; Liu, XG1; Chan, CK1; Yuen, MF1; Hui, WM1; Lam, SK1
刊名: ALIMENTARY PHARMACOLOGY & THERAPEUTICS
发表日期: 2001-06-01
卷: 15, 期:6, 页:843-849
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology ; Pharmacology & Pharmacy
研究领域[WOS]: Gastroenterology & Hepatology ; Pharmacology & Pharmacy
关键词[WOS]: WEEK TRIPLE THERAPY ; ROUTINE TREATMENT ; INFECTION ; CLARITHROMYCIN ; METRONIDAZOLE ; ERADICATION ; TRIAL ; CURE ; OMEPRAZOLE ; 2-DAY
英文摘要:

Aim: To compare the efficacy and tolerability of a 3-day quadruple therapy with a standard 7-day triple therapy in eradicating Helicobacter pylori infection and healing duodenal ulcers.

Methods: Patients with H. pylori-positive duodenal ulcers were randomized to receive either lansoprazole 30 mg, clarithromycin 500 mg, and metronidazole 400 mg twice daily for 7 days (LCM-7) or lansoprazole 30 mg, clarithromycin 500 mg, metronidazole 400 mg, and bismuth subcitrate 240 mg twice daily for 3 days (LCMB-3). No pre- or post-treatment acid suppression was used. Follow-up endoscopy was performed at week 6.

Results: A total of 118 patients were recruited. Sixty patients in the LCM-7 group and 53 patients in the LCMB-3 group returned for endoscopy. Intention-to-treat eradication rates were 87% and 86% (P=0.94) and per protocol eradication rates were 87% and 94% (P=0.29) in the LCM-7 and LCMB-3 groups, respectively. Per protocol and intention-to-treat ulcer healing rates were 98% and 98% in LCM-7 and 100% and 91% in LCMB-3, respectively. There were no significant differences in efficacy in relation to the initial metronidazole and clarithromycin susceptibility. Significant reduction in the duration of side-effects was found in the LCMB-3 group.

Conclusion: The 3-day quadruple therapy is highly effective, better tolerated and can be considered as a first-line therapy in duodenal ulcer management.

语种: 英语
WOS记录号: WOS:000168747600011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51979
Appears in Collections:北京大学第一临床医学院_大内科_期刊论文

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作者单位: 1.United Christian Hosp, Dept Med, Hong Kong, Hong Kong, Peoples R China
2.Univ Hong Kong, Queen Mary Hosp, Dept Med, Hong Kong, Hong Kong, Peoples R China
3.Univ Hong Kong, Queen Mary Hosp, Dept Surg, Hong Kong, Hong Kong, Peoples R China
4.Beijing Med Univ, Teaching Hosp 1, Dept Internal Med, Beijing, Peoples R China

Recommended Citation:
Wong, BCY,Wang, WH,Wong, WM,et al. Three-day lansoprazole quadruple therapy for Helicobacter pylori-positive duodenal ulcers: a randomized controlled study[J]. ALIMENTARY PHARMACOLOGY & THERAPEUTICS,2001,15(6):843-849.
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