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学科主题: 药学
题名:
Synthesis and antithrombotic activity of carbolinecarboxyl RGD sequence
作者: Lin, N; Zhao, M; Wang, C; Peng, SQ
刊名: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
发表日期: 2002-02-25
卷: 12, 期:4, 页:585-587
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Medicinal ; Chemistry, Organic
研究领域[WOS]: Pharmacology & Pharmacy ; Chemistry
关键词[WOS]: PLATELET-AGGREGATION ; PEPTIDES ; FIBRINOGEN
英文摘要:

3S-1,2,3,4-Tetrahydro-beta-carboline-3-carboxylic acid, RGDS, RGDV, RGDF and their linkers were synthesized. The anti-aggregation and adhesion of platelet indicated that the in vitro activities of the linkers remained at the same level as RGDS, RGDV, and RGDF (p > 0.05). The antithrombotic activities in vivo suggested, however, that the potencies of RGDS, RGDV and RGDF were enhanced by the introduction of 3S-1,2,3,4-tetrahydo-beta-carboline-3-carboxyl group into their alpha amino group (p < 0.05, 0.01 or 0.001). (C) 2002 Elsevier Science Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000174280700017
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51981
Appears in Collections:北京大学药学院_期刊论文

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作者单位: Peking Univ, Coll Pharmaceut Sci, Beijing 100083, Peoples R China

Recommended Citation:
Lin, N,Zhao, M,Wang, C,et al. Synthesis and antithrombotic activity of carbolinecarboxyl RGD sequence[J]. BIOORGANIC &amp; MEDICINAL CHEMISTRY LETTERS,2002,12(4):585-587.
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