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Synthesis and antithrombotic activity of carbolinecarboxyl RGD sequence
Lin, N; Zhao, M; Wang, C; Peng, SQ
刊名BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
2002-02-25
12期:4页:585-587
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal ; Chemistry, Organic
研究领域[WOS]Pharmacology & Pharmacy ; Chemistry
关键词[WOS]PLATELET-AGGREGATION ; PEPTIDES ; FIBRINOGEN
英文摘要

3S-1,2,3,4-Tetrahydro-beta-carboline-3-carboxylic acid, RGDS, RGDV, RGDF and their linkers were synthesized. The anti-aggregation and adhesion of platelet indicated that the in vitro activities of the linkers remained at the same level as RGDS, RGDV, and RGDF (p > 0.05). The antithrombotic activities in vivo suggested, however, that the potencies of RGDS, RGDV and RGDF were enhanced by the introduction of 3S-1,2,3,4-tetrahydo-beta-carboline-3-carboxyl group into their alpha amino group (p < 0.05, 0.01 or 0.001). (C) 2002 Elsevier Science Ltd. All rights reserved.

语种英语
WOS记录号WOS:000174280700017
引用统计
被引频次:29[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51981
专题北京大学药学院
作者单位Peking Univ, Coll Pharmaceut Sci, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Lin, N,Zhao, M,Wang, C,et al. Synthesis and antithrombotic activity of carbolinecarboxyl RGD sequence[J]. BIOORGANIC &amp; MEDICINAL CHEMISTRY LETTERS,2002,12(4):585-587.
APA Lin, N,Zhao, M,Wang, C,&Peng, SQ.(2002).Synthesis and antithrombotic activity of carbolinecarboxyl RGD sequence.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,12(4),585-587.
MLA Lin, N,et al."Synthesis and antithrombotic activity of carbolinecarboxyl RGD sequence".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 12.4(2002):585-587.
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