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学科主题基础医学
Apocrine mixed tumors of the skin with architectural and/or cytologic atypia: A retrospective clinicopathologic study of 18 cases
Kazakov, Dmitry V.1; Bisceglia, Michele1; Spagnolo, Dominic V.1; Kutzner, Heinz1; Belousova, Irena E.1; Hes, Ondrej1; Sima, Radek1; Vanecek, Tomas1; Yang, Yu1; Michal, Michal1
关键词skin adnexal tumors chondroid syringoma apocrine mixed tumor malignant mixed tumor pleomorphic adenoma hyaline cell HER-2/neu polysomy 17
刊名AMERICAN JOURNAL OF SURGICAL PATHOLOGY
2007-07-01
31期:7页:1094-1102
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pathology ; Surgery
研究领域[WOS]Pathology ; Surgery
关键词[WOS]EX PLEOMORPHIC ADENOMA ; RICH CHONDROID SYRINGOMA ; IN-SITU HYBRIDIZATION ; SALIVARY-GLANDS ; CUTANEOUS MYOEPITHELIOMA ; BREAST CARCINOMAS ; HER-2/NEU GENE ; PAROTID-GLAND ; SOFT-TISSUES ; CELLS
英文摘要

We present a series of 18 atypical apocrine mixed tumors of the skin characterized by architectural and/or cytologic atypia but which nevertheless do not qualify these lesions as carcinomas. There were 15 males and 3 females, and all but I presented with solitary nodules ranging in size from 4 to 20 mm; I female had a large tumor of 12 cm. The tumors were preferentially located on the head area, especially the face (13 cases). Other locations included the lower extremities (3) and inguinal area (2). In all patients, surgical excision of the tumors was performed. Clinical follow-up was available in 11 cases and ranged from I to 24 years (mean 9.6 y; median 5 y). No recurrences or metastases were documented. Overall, the lesions manifested a rather benign architecture, usually with good circumscription, lack of capsular breach or hypercellularity; however, some asymmetry, focally irregular infiltrationlike or pushing tumorous borders were seen. Microscopically, 17 cases conformed to the so-called hyaline cell-rich variant and showed multinucleated, bizarre, hyperchromatic cells in hyaline cell areas that had a myoepithelial immunophenotype; in 1 case, atypical mitotic figures were noted. One case showed mild nuclear pleomorphism in the ductal component. Tumors were negative for p53, including bizarre giant cells that did not label with Ki-67. UItrastructurally, hyaline cells exhibited features consistent with myoepithelial differentiation. Seven cases studied by immunohistochemistry proved negative for HER-2/neu (c-erbB-2) protein expression, and the HER-2/neu gene was not amplified by fluorescence in situ hybridization analysis in 5 cases tested. As controls, 4 authentic malignant mixed tumors were studied, but these likewise tested negative for HER-2/neu protein expression and showed no gene amplification; 1 malignant mixed tumor had polysomy 17. We conclude that some atypical cytoarchitectural features in apocrine mixed tumors, albeit worrisome, do not indicate a malignant change.

语种英语
WOS记录号WOS:000247573700015
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被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51983
专题北京大学基础医学院_病理学系
作者单位1.Mil Med Acad, Dept Dermatol, St Petersburg, Russia
2.Dermatohistopathol Gemeinschaftspraxis, Friedrichshafen, Germany
3.Charles Univ Prague, Med Fac Hosp, Dept Pathol, Plzen 30460, Czech Republic
4.Osped Casa Sollievto Sofferenza, IRCCS, Dept Pathol, San Giovanni Rotondo, Italy
5.PathWest Lab Med, Div Tissue Pathol, Nedlands, WA, Australia
6.Peking Univ, Hlth Sci Ctr, Dept Pathol, Beijing 100871, Peoples R China
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Kazakov, Dmitry V.,Bisceglia, Michele,Spagnolo, Dominic V.,et al. Apocrine mixed tumors of the skin with architectural and/or cytologic atypia: A retrospective clinicopathologic study of 18 cases[J]. AMERICAN JOURNAL OF SURGICAL PATHOLOGY,2007,31(7):1094-1102.
APA Kazakov, Dmitry V..,Bisceglia, Michele.,Spagnolo, Dominic V..,Kutzner, Heinz.,Belousova, Irena E..,...&Michal, Michal.(2007).Apocrine mixed tumors of the skin with architectural and/or cytologic atypia: A retrospective clinicopathologic study of 18 cases.AMERICAN JOURNAL OF SURGICAL PATHOLOGY,31(7),1094-1102.
MLA Kazakov, Dmitry V.,et al."Apocrine mixed tumors of the skin with architectural and/or cytologic atypia: A retrospective clinicopathologic study of 18 cases".AMERICAN JOURNAL OF SURGICAL PATHOLOGY 31.7(2007):1094-1102.
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