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学科主题: 基础医学
题名:
Enzymatic removal of hyaluronan affects routing of axons in the mouse optic chiasm
作者: Chan, Chung-Kit1; Wang, Jun1; Lin, Ling1; Hao, Yanli1; Chan, Sun-On1
关键词: axon guidance ; CD44 ; extracellular matrix ; hyaluronic acid ; midline ; retina
刊名: NEUROREPORT
发表日期: 2007-10-08
卷: 18, 期:15, 页:1533-1538
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: RETINOFUGAL PATHWAY ; CHONDROITIN SULFATE ; EMBRYOS ; CD44 ; DIVERGENCE ; EXPRESSION ; NEURONS ; GROWTH ; CELLS
英文摘要:

Perturbations of interaction of hyaluronan (HA) with its receptor CD44 cause multiple errors in axon routing at the mouse optic chiasm. To investigate this interaction further on the chiasm routing, we studied the axon routing after enzymatic removal of HA from slice preparations of the optic pathway. Hyaluronidase treatment produced an obvious reduction in midline crossing of the first generated axons in E13 chiasms, but had no influence on routing of the uncrossed axons in E15 and E16 slices. These findings support a direct role of HA, acting probably through CD44, on axon decussation during early phase of chiasm development, but argue against a direct function of HA on the turning of uncrossed axons in the mouse optic chiasm.

语种: 英语
WOS记录号: WOS:000249853200006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51985
Appears in Collections:基础医学院_期刊论文

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作者单位: 1.Chinese Univ Hong Kong, Dept Anat, Shatin, Hong Kong, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Anat & Embryol, Beijing 100871, Peoples R China

Recommended Citation:
Chan, Chung-Kit,Wang, Jun,Lin, Ling,et al. Enzymatic removal of hyaluronan affects routing of axons in the mouse optic chiasm[J]. NEUROREPORT,2007,18(15):1533-1538.
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