IR@PKUHSC  > 北京大学第二临床医学院  > 泌尿外科
学科主题临床医学
Growth inhibiting effects of terazosin on androgen-independent prostate cancer cell lines
Xu, KX1; Wang, XH1; Ling, MT1; Wong, YC1
关键词Prostate Cancer Adrenergic Receptor Antagonist Drug Effects
刊名CHINESE MEDICAL JOURNAL
2003-11-01
116期:11页:1673-1677
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]DEPENDENT KINASE INHIBITOR ; TUMOR-SUPPRESSOR ; CARCINOMA-CELLS ; APOPTOSIS ; HYPERPLASIA ; P27(KIP1) ; PROLIFERATION ; PROGRESSION ; DOXAZOSIN ; SIGNALS
英文摘要

Objective To study the effects of an alpha(1)-adrenoceptor antagonist, terazosin on the androgen-independent prostate cancer cell lines PC-3 and DU145.

Methods Two androgen independent cell lines, PC-3 and DU145, were used to determine cell viability, colony-forming ability, as well as cell cycle distribution, after exposure to terazosin. Western blot analysis was used to determine the expression of p21WAF1 and p27KIP1.

Results This study shows that terazosin inhibits not only prostate cancer cell growth but also its colony forming ability, both of which are main targets of clinical treatment. In addition, terazosin is shown to inhibit cell growth through G1 phase cell cycle arrest and the up-regulation of p27(KIP1).

Conclusion This study provides evidence that the alpha(1)-adrenoceptor antagonist terazosin may have therapeutic potential in the treatment of advanced hormone refractory prostate cancer.

语种英语
WOS记录号WOS:000187462900009
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51988
Collection北京大学第二临床医学院_泌尿外科
北京大学第三临床医学院_放射科
北京大学口腔医学院_教育处
作者单位1.Peking Univ, Peoples Hosp, Dept Urol, Beijing 100044, Peoples R China
2.Univ Hong Kong, Fac Med, Dept Anat, Hong Kong, Hong Kong, Peoples R China
Recommended Citation
GB/T 7714
Xu, KX,Wang, XH,Ling, MT,et al. Growth inhibiting effects of terazosin on androgen-independent prostate cancer cell lines[J]. CHINESE MEDICAL JOURNAL,2003,116(11):1673-1677.
APA Xu, KX,Wang, XH,Ling, MT,&Wong, YC.(2003).Growth inhibiting effects of terazosin on androgen-independent prostate cancer cell lines.CHINESE MEDICAL JOURNAL,116(11),1673-1677.
MLA Xu, KX,et al."Growth inhibiting effects of terazosin on androgen-independent prostate cancer cell lines".CHINESE MEDICAL JOURNAL 116.11(2003):1673-1677.
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