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学科主题: 临床医学
题名:
A novel microbead-based microfluidic device for rapid bacterial identification and antibiotic susceptibility testing
作者: He, J.1; Mu, X.2; Guo, Z.1; Hao, H.1; Zhang, C.3; Zhao, Z.4; Wang, Q.1
刊名: EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
发表日期: 2014-12-01
DOI: 10.1007/s10096-014-2182-z
卷: 33, 期:12, 页:2223-2230
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Infectious Diseases ; Microbiology
研究领域[WOS]: Infectious Diseases ; Microbiology
关键词[WOS]: POLY(DIMETHYLSILOXANE) ; DROPLETS ; SYSTEMS ; SEPSIS ; FLOW
英文摘要:

Effective treatment of infectious diseases depends on the ability to rapidly identify the infecting bacteria and the use of sensitive antibiotics. The currently used identification assays usually take more than 72 h to perform and have a low sensitivity. Herein, we present a microbead-based microfluidic platform that is highly sensitive and rapid for bacterial detection and antibiotic sensitivity testing. The platform includes four units, one of which is used for bacterial identification and the other three are used for susceptibility testing. Our results showed that Escherichia coli O157 at a cell density range of 10(1)-10(5) CFU/mu L could be detected within 30 min. Additionally, the effects of three antibiotics on E. coli O157 were evaluated within 4-8 h. Overall, this integrated microbead-based microdevice provides a sensitive, rapid, reliable, and highly effective platform for the identification of bacteria, as well as antibiotic sensitivity testing.

语种: 英语
所属项目编号: 201202011
项目资助者: National Health and Family Planning Commission of China
WOS记录号: WOS:000345138300016
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51989
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Dalian Med Univ, Hosp 2, Dept Resp Med, Dalian 116023, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Resp & Crit Care Med, Beijing 100044, Peoples R China
3.Dalian Med Univ, Hosp 2, Dept Endocrinol Med, Dalian 116023, Peoples R China
4.Dalian Med Univ, Hosp 2, Dept Breast Surg Med, Dalian 116023, Peoples R China

Recommended Citation:
He, J.,Mu, X.,Guo, Z.,et al. A novel microbead-based microfluidic device for rapid bacterial identification and antibiotic susceptibility testing[J]. EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES,2014,33(12):2223-2230.
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