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学科主题: 临床医学
题名:
c-Fos, N-methyl-D-aspartate receptor 2C, GABA-A-alpha 1 immonoreactivity, seizure latency and neuronal injury following single or recurrent neonatal seizures in hippocampus of Wistar rat
作者: Ni, H; Jiang, YW; Bo, T; Wang, JM; Wu, XR
关键词: neonatal seizures ; seizure-induced brain injury ; seizure threshold ; hippocampus ; GABA-A-alpha 1
刊名: NEUROSCIENCE LETTERS
发表日期: 2005-05-20
卷: 380, 期:1-2, 页:149-154
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: ACID-INDUCED SEIZURES ; EXPRESSION ; BRAIN ; AGE
英文摘要:

To evaluate the long-term effects of single or recurrent prolonged neonatal seizures on seizure threshold and neuronal activity in the brain, a novel "twist" seizure was induced by coupling early-life flurothyl-induced seizures with later exposure to pentylenetetrazol. The authors assigned six neonatal rats for each group: the single-seizure group (SS), the recurrent-seizure group (RS) and the control group. At postnatal day 46, seizure threshold was examined using pentylenetetrazol, and then the brain slices were evaluated with thionine staining, in situ end labeling and immunohistochemical studies. The Results showed that the rats in SS and RS groups all had reduced latencies to develop generalized tonic seizures induced by PTZ compared with controls (P < 0.01). Morphologic changes, cell loss and apoptotic cells were observed only in those of RS group. Significant fos and NR2C-immunoreactive positive cells were seen in hippocampus of rats in both SS and RS groups compared with controls (P < 0.01). A significant decrease in the number of GABA-A-α 1 immunoreactive positive neurons was detected in hippocampus in rats of SS and RS groups compared with the controls (P < 0.01). We conclude that neonatal rats subjected to prolonged seizures have pronounced long-term effects on seizure threshold and neuronal neurophysiological activity in the brain. Obvious neuronal injury, however, was only seen in rat with recurrent-seizures. Subtle brain damage might occur in rats experiencing single prolonged neonatal seizures. © 2005 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000228958600029
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51994
Appears in Collections:北京大学第一临床医学院_儿科_期刊论文

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作者单位: Peking Univ, Dept Pediat, Hosp 1, Beijing 100034, Peoples R China

Recommended Citation:
Ni, H,Jiang, YW,Bo, T,et al. c-Fos, N-methyl-D-aspartate receptor 2C, GABA-A-alpha 1 immonoreactivity, seizure latency and neuronal injury following single or recurrent neonatal seizures in hippocampus of Wistar rat[J]. NEUROSCIENCE LETTERS,2005,380(1-2):149-154.
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