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c-Fos, N-methyl-D-aspartate receptor 2C, GABA-A-alpha 1 immonoreactivity, seizure latency and neuronal injury following single or recurrent neonatal seizures in hippocampus of Wistar rat
Ni, H; Jiang, YW; Bo, T; Wang, JM; Wu, XR
关键词Neonatal Seizures Seizure-induced Brain Injury Seizure Threshold Hippocampus Gaba-a-alpha 1
刊名NEUROSCIENCE LETTERS
2005-05-20
380期:1-2页:149-154
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]ACID-INDUCED SEIZURES ; EXPRESSION ; BRAIN ; AGE
英文摘要

To evaluate the long-term effects of single or recurrent prolonged neonatal seizures on seizure threshold and neuronal activity in the brain, a novel "twist" seizure was induced by coupling early-life flurothyl-induced seizures with later exposure to pentylenetetrazol. The authors assigned six neonatal rats for each group: the single-seizure group (SS), the recurrent-seizure group (RS) and the control group. At postnatal day 46, seizure threshold was examined using pentylenetetrazol, and then the brain slices were evaluated with thionine staining, in situ end labeling and immunohistochemical studies. The Results showed that the rats in SS and RS groups all had reduced latencies to develop generalized tonic seizures induced by PTZ compared with controls (P < 0.01). Morphologic changes, cell loss and apoptotic cells were observed only in those of RS group. Significant fos and NR2C-immunoreactive positive cells were seen in hippocampus of rats in both SS and RS groups compared with controls (P < 0.01). A significant decrease in the number of GABA-A-α 1 immunoreactive positive neurons was detected in hippocampus in rats of SS and RS groups compared with the controls (P < 0.01). We conclude that neonatal rats subjected to prolonged seizures have pronounced long-term effects on seizure threshold and neuronal neurophysiological activity in the brain. Obvious neuronal injury, however, was only seen in rat with recurrent-seizures. Subtle brain damage might occur in rats experiencing single prolonged neonatal seizures. © 2005 Elsevier Ireland Ltd. All rights reserved.

语种英语
WOS记录号WOS:000228958600029
引用统计
被引频次:22[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51994
专题北京大学第一临床医学院_儿科
作者单位Peking Univ, Dept Pediat, Hosp 1, Beijing 100034, Peoples R China
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GB/T 7714
Ni, H,Jiang, YW,Bo, T,et al. c-Fos, N-methyl-D-aspartate receptor 2C, GABA-A-alpha 1 immonoreactivity, seizure latency and neuronal injury following single or recurrent neonatal seizures in hippocampus of Wistar rat[J]. NEUROSCIENCE LETTERS,2005,380(1-2):149-154.
APA Ni, H,Jiang, YW,Bo, T,Wang, JM,&Wu, XR.(2005).c-Fos, N-methyl-D-aspartate receptor 2C, GABA-A-alpha 1 immonoreactivity, seizure latency and neuronal injury following single or recurrent neonatal seizures in hippocampus of Wistar rat.NEUROSCIENCE LETTERS,380(1-2),149-154.
MLA Ni, H,et al."c-Fos, N-methyl-D-aspartate receptor 2C, GABA-A-alpha 1 immonoreactivity, seizure latency and neuronal injury following single or recurrent neonatal seizures in hippocampus of Wistar rat".NEUROSCIENCE LETTERS 380.1-2(2005):149-154.
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