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学科主题: 临床医学
题名:
Value of c-Met for predicting progression of precancerous gastric lesions in rural Chinese population
作者: Sun, Yu1; Tian, Meng-meng1; Zhou, Li-xin1; You, Wei-cheng2; Li, Ji-you1
关键词: c-Met ; Intestinal metaplasia ; Dysplasia ; Follow-up
刊名: CHINESE JOURNAL OF CANCER RESEARCH
发表日期: 2012-03-01
DOI: 10.1007/s11670-012-0018-x
卷: 24, 期:1, 页:18-22
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: INTESTINAL METAPLASIA ; PRECURSOR LESIONS ; TYROSINE KINASE ; INVASIVE GROWTH ; HIGH-RISK ; CANCER ; OVEREXPRESSION ; ACTIVATION ; CARCINOMA ; STOMACH
英文摘要:

To investigate the value of c-Met in predicting progression of precancerous gastric lesions.

A population-based study was conducted to detect the overexpression of c-Met by immunohistochemical analysis in 124 subjects with precancerous gastric lesions. Odds ratio (OR) and 95% confidence interval (95% CI) were calculated for the association of c-Met overexpression with the risk of advanced gastric lesions.

The positive rates of c-Met were 55.7% in intestinal metaplasia (IM) and 64.8% in dysplasia (DYS), respectively. Stratified analysis indicated that the proportion of c-Met overexpression was 71.4% for IM progressive group, significantly higher than that for IM persistent group (40.0%, P < 0.05). Compared to the IM persistent group, unconditional logistic regression showed that OR of c-Met overexpression for the IM progressive group was 7.416 (95% CI: 2.084-26.398).

c-Met plays an important role in gastric carcinogenesis. Detection of c-Met is of value in predicting progression of precancerous gastric lesions from IM to DYS.

语种: 英语
所属项目编号: 2009BG-02 ; 2006AA02A402 ; 2004CB518702
项目资助者: Beijing Municipal Science &amp ; Technology Commission NOVA ; National "863" High Technology Research and Development Program of China ; National "973" Major Basic Research Program of China
WOS记录号: WOS:000300313500003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51997
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: 1.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst,Dept Pathol, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China
2.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst,Dept Epidemiol, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China

Recommended Citation:
Sun, Yu,Tian, Meng-meng,Zhou, Li-xin,et al. Value of c-Met for predicting progression of precancerous gastric lesions in rural Chinese population[J]. CHINESE JOURNAL OF CANCER RESEARCH,2012,24(1):18-22.
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