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学科主题医学信息学
Recombination rates of human microRNA
Zhao, Huizhi1,2,3; Wang, Dong3,4; Liu, Bing1,2; Jiang, Xingpeng1,2; Zhang, Jing1,2; Fan, Ming1,2; Fan, Zhengjie1,2; Chen, Ying1,2; Song, Sonya Wei1,2; Gao, Wei3,4; Jiang, Tianzi1,2; Cui, Qinghua3,4
关键词Micrornas Recombination Rate Tissue Specificity Disease Microrna Expression Level
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2009-02-13
DOI10.1016/j.bbrc.2008.12.144
379期:3页:702-705
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]HUMAN GENOME ; GENETIC ROBUSTNESS ; HUMAN TISSUES ; GC CONTENT ; EXPRESSION ; EVOLUTION ; PROFILES ; CANCER ; BIAS
英文摘要

The fact that microRNAs play a role in almost all biological processes is well established, as is the importance of recombination in generating genome variability. However, the association between microRNAs and recombination remains largely unknown. In order to investigate the recombination patterns of microRNAs, we performed a comprehensive analysis of the recombination rate of human microRNAs. We observed that microRNAs that are expressed in several tissues tend to have lower recombination rates than tissue-specific microRNAs. Additionally, microRNAs that are associated with a number of diseases are also likely to have lower recombination rates. Furthermore, microRNAs with higher expression levels are found to have fewer recombination events. These findings reveal patterns in recombination rates of microRNAs that could help ill understanding the function, evolution, and disease-related roles of microRNAs. (C) 2008 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000263258100011
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被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51998
专题北京大学基础医学院_医学信息学系
北京大学基础医学院
北京大学第三临床医学院_心血管内科
作者单位1.Chinese Acad Sci, Inst Automat, LIAMA Ctr Computat Med, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Med Informat, Beijing 100083, Peoples R China
4.Peking Univ, MOE Key Lab Mol Cardiol, Beijing 100191, Peoples R China
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Zhao, Huizhi,Wang, Dong,Liu, Bing,et al. Recombination rates of human microRNA[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2009,379(3):702-705.
APA Zhao, Huizhi.,Wang, Dong.,Liu, Bing.,Jiang, Xingpeng.,Zhang, Jing.,...&Cui, Qinghua.(2009).Recombination rates of human microRNA.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,379(3),702-705.
MLA Zhao, Huizhi,et al."Recombination rates of human microRNA".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 379.3(2009):702-705.
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