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学科主题临床医学
Neoadjuvant therapy for advanced rectal carcinoma in China: Whether radiochemotherapy is superior to radiotherapy?
Cai, Yong3; Du, Chang-zheng1; Zhu, Xiang-gao3; Xu, Bo3; Li, Ming1; Gu, Jin1
关键词Rectal Carcinoma Neoadjuvant Radiotherapy Total Mesorectal Excision Tumor Downstaging Pathologic Complete Response
刊名CHINESE JOURNAL OF CANCER RESEARCH
2009-12-01
DOI10.1007/s11670-009-0295-1
21期:4页:295-303
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]TOTAL MESORECTAL EXCISION ; COMBINED-MODALITY THERAPY ; CONTINUOUS-INFUSION 5-FU ; PREOPERATIVE RADIOTHERAPY ; SPHINCTER PRESERVATION ; RANDOMIZED-TRIAL ; CANCER ; CHEMOTHERAPY ; RADIATION ; CHEMORADIOTHERAPY
英文摘要

To verify whether the 30 Gy preoperative radiotherapy regimen is effective to advanced rectal cancer, and whether the preoperative chemoradiation offers an advantage in sphincter preservation and tumor control compared with irradiation alone.

A total of 141 patients administered neoadjuvant treatment with resectable lower rectal carcinoma from 2002 to 2006 were collected retrospectively. The patients were divided into two groups: preoperative radiotherapy alone (30Gy by 10 fractions) (PRT group) and preoperative chemoradiotherapy (PCRT group). All patients underwent radical surgery after neoadjuvant treatment.

The overall sphincter-preservation rate was 68.8% (97/141), with no significant difference between the two groups. The overall downstaging rate was 48.2% (68/141), including 4 patients completely response (2.8%). The T and N downstaging rate were 30.5% (43/141) and 53.8% (57/106) respectively, showing no statistically difference between the two groups. The 2-year overall survival rate was 93.6%; no survival benefit were observed in PCRT group. The 2-year cumulative local recurrence rates were similar as well (4.2% vs 6.7%, P=0.63). Two patients with severe marrow suppression higher than grade 3 and 1 patient with severe perineum ulcer was observed in PCRT group, which did not occur in PRT group.

The preoperative adjuvant treatment of 30Gy radiotherapy alone may be an optional treatment for Chinese lower rectal carcinoma. Preoperative chemoradiotherapy does not show actual superiority compared with radiotherapy alone.

语种英语
WOS记录号WOS:000272158500007
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52002
专题北京大学临床肿瘤学院_胃肠肿瘤中心
北京大学第二临床医学院_放疗科
北京大学临床肿瘤学院_肿瘤放疗科
北京大学临床肿瘤学院_结直肠肿瘤外科
作者单位1.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst, Dept Colorectal Surg, Beijing 100142, Peoples R China
2.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China
3.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst, Dept Radiotherapy, Beijing 100142, Peoples R China
推荐引用方式
GB/T 7714
Cai, Yong,Du, Chang-zheng,Zhu, Xiang-gao,et al. Neoadjuvant therapy for advanced rectal carcinoma in China: Whether radiochemotherapy is superior to radiotherapy?[J]. CHINESE JOURNAL OF CANCER RESEARCH,2009,21(4):295-303.
APA Cai, Yong,Du, Chang-zheng,Zhu, Xiang-gao,Xu, Bo,Li, Ming,&Gu, Jin.(2009).Neoadjuvant therapy for advanced rectal carcinoma in China: Whether radiochemotherapy is superior to radiotherapy?.CHINESE JOURNAL OF CANCER RESEARCH,21(4),295-303.
MLA Cai, Yong,et al."Neoadjuvant therapy for advanced rectal carcinoma in China: Whether radiochemotherapy is superior to radiotherapy?".CHINESE JOURNAL OF CANCER RESEARCH 21.4(2009):295-303.
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