北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学临床肿瘤学院  > 胃肠肿瘤中心  > 期刊论文
学科主题: 临床医学
题名:
Neoadjuvant therapy for advanced rectal carcinoma in China: Whether radiochemotherapy is superior to radiotherapy?
作者: Cai, Yong3; Du, Chang-zheng1; Zhu, Xiang-gao3; Xu, Bo3; Li, Ming1; Gu, Jin1
关键词: Rectal carcinoma ; Neoadjuvant radiotherapy ; Total mesorectal excision ; Tumor downstaging ; Pathologic complete response
刊名: CHINESE JOURNAL OF CANCER RESEARCH
发表日期: 2009-12-01
DOI: 10.1007/s11670-009-0295-1
卷: 21, 期:4, 页:295-303
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: TOTAL MESORECTAL EXCISION ; COMBINED-MODALITY THERAPY ; CONTINUOUS-INFUSION 5-FU ; PREOPERATIVE RADIOTHERAPY ; SPHINCTER PRESERVATION ; RANDOMIZED-TRIAL ; CANCER ; CHEMOTHERAPY ; RADIATION ; CHEMORADIOTHERAPY
英文摘要:

To verify whether the 30 Gy preoperative radiotherapy regimen is effective to advanced rectal cancer, and whether the preoperative chemoradiation offers an advantage in sphincter preservation and tumor control compared with irradiation alone.

A total of 141 patients administered neoadjuvant treatment with resectable lower rectal carcinoma from 2002 to 2006 were collected retrospectively. The patients were divided into two groups: preoperative radiotherapy alone (30Gy by 10 fractions) (PRT group) and preoperative chemoradiotherapy (PCRT group). All patients underwent radical surgery after neoadjuvant treatment.

The overall sphincter-preservation rate was 68.8% (97/141), with no significant difference between the two groups. The overall downstaging rate was 48.2% (68/141), including 4 patients completely response (2.8%). The T and N downstaging rate were 30.5% (43/141) and 53.8% (57/106) respectively, showing no statistically difference between the two groups. The 2-year overall survival rate was 93.6%; no survival benefit were observed in PCRT group. The 2-year cumulative local recurrence rates were similar as well (4.2% vs 6.7%, P=0.63). Two patients with severe marrow suppression higher than grade 3 and 1 patient with severe perineum ulcer was observed in PCRT group, which did not occur in PRT group.

The preoperative adjuvant treatment of 30Gy radiotherapy alone may be an optional treatment for Chinese lower rectal carcinoma. Preoperative chemoradiotherapy does not show actual superiority compared with radiotherapy alone.

语种: 英语
WOS记录号: WOS:000272158500007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52002
Appears in Collections:北京大学临床肿瘤学院_胃肠肿瘤中心_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst, Dept Colorectal Surg, Beijing 100142, Peoples R China
2.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China
3.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst, Dept Radiotherapy, Beijing 100142, Peoples R China

Recommended Citation:
Cai, Yong,Du, Chang-zheng,Zhu, Xiang-gao,et al. Neoadjuvant therapy for advanced rectal carcinoma in China: Whether radiochemotherapy is superior to radiotherapy?[J]. CHINESE JOURNAL OF CANCER RESEARCH,2009,21(4):295-303.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Cai, Yong]'s Articles
[Du, Chang-zheng]'s Articles
[Zhu, Xiang-gao]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Cai, Yong]‘s Articles
[Du, Chang-zheng]‘s Articles
[Zhu, Xiang-gao]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace