IR@PKUHSC  > 北京大学基础医学院  > 病原生物学系
学科主题基础医学
Electrospun water-soluble carboxyethyl chitosan/poly(vinyl alcohol) nanofibrous membrane as potential wound dressing for skin regeneration
Zhou, Yingshan1; Yang, Dongzhi2,3; Chen, Xiangmei4; Xu, Qiang4; Lu, Fengmin4; Nie, Jun2,3
刊名BIOMACROMOLECULES
2008
DOI10.1021/bm7009015
9期:1页:349-354
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Chemistry, Organic ; Polymer Science
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry ; Polymer Science
关键词[WOS]POLY(VINYL ALCOHOL) ; CROSS-LINKING ; AQUEOUS-SOLUTIONS ; CHITOSAN ; TISSUE ; ACID ; MORPHOLOGY ; SCAFFOLDS ; GELATIN ; FIBERS
英文摘要

Biocompatible carboxyethyl chitosan/poly(vinyl alcohol) (CECS/PVA) nanofibers were successfully prepared by electrospinning of aqueous CECS/PVA solution. The composite nanofibrous membranes were subjected to detailed analysis by scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and X-ray diffraction (XRD). SEM images showed that the morphology and diameter of the nanofibers were mainly affected by the weight ratio of CECS/PVA. XRD and DSC demonstrated that there was strong intermolecular hydrogen bonding between the molecules of CECS and PVA. The crystalline microstructure of the electrospun fibers was not well developed. The potential use of the CECS/PVA electrospun fiber mats as scaffolding materials for skin regeneration was evaluated in vitro using mouse fibroblasts (L929) as reference cell lines. Indirect cytotoxicity assessment of the fiber mats indicated that the CECS/PVA electrospun mat was nontoxic to the L929 cell. Cell culture results showed that fibrous mats were good in promoting the cell attachment and proliferation. This novel electrospun matrix would be. used as potential wound dressing for skin regeneration.

语种英语
WOS记录号WOS:000252415600047
Citation statistics
Cited Times:220[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52005
Collection北京大学基础医学院_病原生物学系
作者单位1.Wuhan Univ, Dept Chem, Key Lab Biomed Polymers, Minist Educ, Wuhan 430072, Peoples R China
2.Beijing Univ Chem Technol, State Key Lab Chem Resource Engn, Beijing 100029, Peoples R China
3.Beijing Univ Chem Technol, Coll Mat Sci & Engn, Beijing 100029, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Dept Microbiol, Beijing 100083, Peoples R China
Recommended Citation
GB/T 7714
Zhou, Yingshan,Yang, Dongzhi,Chen, Xiangmei,et al. Electrospun water-soluble carboxyethyl chitosan/poly(vinyl alcohol) nanofibrous membrane as potential wound dressing for skin regeneration[J]. BIOMACROMOLECULES,2008,9(1):349-354.
APA Zhou, Yingshan,Yang, Dongzhi,Chen, Xiangmei,Xu, Qiang,Lu, Fengmin,&Nie, Jun.(2008).Electrospun water-soluble carboxyethyl chitosan/poly(vinyl alcohol) nanofibrous membrane as potential wound dressing for skin regeneration.BIOMACROMOLECULES,9(1),349-354.
MLA Zhou, Yingshan,et al."Electrospun water-soluble carboxyethyl chitosan/poly(vinyl alcohol) nanofibrous membrane as potential wound dressing for skin regeneration".BIOMACROMOLECULES 9.1(2008):349-354.
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