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学科主题: 基础医学
题名:
Electrospun water-soluble carboxyethyl chitosan/poly(vinyl alcohol) nanofibrous membrane as potential wound dressing for skin regeneration
作者: Zhou, Yingshan1; Yang, Dongzhi2,3; Chen, Xiangmei4; Xu, Qiang4; Lu, Fengmin4; Nie, Jun2,3
刊名: BIOMACROMOLECULES
发表日期: 2008
DOI: 10.1021/bm7009015
卷: 9, 期:1, 页:349-354
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Chemistry, Organic ; Polymer Science
研究领域[WOS]: Biochemistry & Molecular Biology ; Chemistry ; Polymer Science
关键词[WOS]: POLY(VINYL ALCOHOL) ; CROSS-LINKING ; AQUEOUS-SOLUTIONS ; CHITOSAN ; TISSUE ; ACID ; MORPHOLOGY ; SCAFFOLDS ; GELATIN ; FIBERS
英文摘要:

Biocompatible carboxyethyl chitosan/poly(vinyl alcohol) (CECS/PVA) nanofibers were successfully prepared by electrospinning of aqueous CECS/PVA solution. The composite nanofibrous membranes were subjected to detailed analysis by scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and X-ray diffraction (XRD). SEM images showed that the morphology and diameter of the nanofibers were mainly affected by the weight ratio of CECS/PVA. XRD and DSC demonstrated that there was strong intermolecular hydrogen bonding between the molecules of CECS and PVA. The crystalline microstructure of the electrospun fibers was not well developed. The potential use of the CECS/PVA electrospun fiber mats as scaffolding materials for skin regeneration was evaluated in vitro using mouse fibroblasts (L929) as reference cell lines. Indirect cytotoxicity assessment of the fiber mats indicated that the CECS/PVA electrospun mat was nontoxic to the L929 cell. Cell culture results showed that fibrous mats were good in promoting the cell attachment and proliferation. This novel electrospun matrix would be. used as potential wound dressing for skin regeneration.

语种: 英语
WOS记录号: WOS:000252415600047
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52005
Appears in Collections:基础医学院_病原生物学系_期刊论文

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作者单位: 1.Wuhan Univ, Dept Chem, Key Lab Biomed Polymers, Minist Educ, Wuhan 430072, Peoples R China
2.Beijing Univ Chem Technol, State Key Lab Chem Resource Engn, Beijing 100029, Peoples R China
3.Beijing Univ Chem Technol, Coll Mat Sci & Engn, Beijing 100029, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Dept Microbiol, Beijing 100083, Peoples R China

Recommended Citation:
Zhou, Yingshan,Yang, Dongzhi,Chen, Xiangmei,et al. Electrospun water-soluble carboxyethyl chitosan/poly(vinyl alcohol) nanofibrous membrane as potential wound dressing for skin regeneration[J]. BIOMACROMOLECULES,2008,9(1):349-354.
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