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学科主题: 临床医学
题名:
Survival Outcome of Squamous Cell Carcinoma Arising from Sinonasal Inverted Papilloma
作者: Liang, Qing-Zhuang1; Li, De-Zhi2; Wang, Xiao-Lei2; Huang, Hui2; Xu, Zhen-Gang2; Wu, Yue-Huang2
关键词: Sinonasal Inverted Papilloma ; Squamous Cell Carcinoma ; Survival Outcome
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2015-09-20
DOI: 10.4103/0366-6999.164929
卷: 128, 期:18, 页:2457-2461
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: RADIATION-THERAPY ; MANAGEMENT ; MALIGNANCY ; TUMORS
英文摘要:

Background: Sinonasal inverted papilloma (IP) is a rare benign tumor of the nasal cavities and paranasal sinuses. It is destructive or bone-remodeling, tends to recur after surgical resection, and has a significant malignant potential. The present study aimed to perform a retrospective analysis of patients with squamous cell carcinoma (SCC) arising from IP, including characteristics, survival outcome, and predictors of associated malignancy.

Methods: The medical records of 213 patients diagnosed with IP from January 1970 to January 2014 were retrospectively reviewed. Eighty-seven patients were diagnosed with SCC/IP; their clinical characteristics, treatments, and survival outcomes were analyzed.

Results: Of the 87 patients with SCC/IP, the 5- and 10-year overall survival outcomes were 39.6% and 31.8%, respectively. Twenty-nine of these patients received surgery and 58 received combined surgery and radiation. Of the patients with stages III-IV, the 5-year survival rate was 30.7% for those treated with surgery only and 39.9% for those given the combination treatment (P = 0.849). Factors associated with significantly poor prognosis were advanced-stage, metachronous tumors, or with cranial base and orbit invasion. Age, synchronous or metachronous tumors, and pathological stage were independent risk factors for mortality, shown by multivariate analysis.

Conclusion: Patients with SCC/IP had low overall survival outcomes. Advanced age, stage, and metachronous tumors are the main factors affecting prognosis. Treatment planning should consider high-risk factors to improve survival outcome.

语种: 英语
WOS记录号: WOS:000361747300008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52007
Appears in Collections:北京大学深圳医院_期刊论文

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作者单位: 1.Peking Univ, Shenzhen Hosp, Dept Breast & Thyroid Surg, Shenzhen 518036, Guangdong, Peoples R China
2.Chinese Acad Med Sci, Peking Union Med Coll, Canc Hosp, Dept Head & Neck Surg, Beijing 100021, Peoples R China

Recommended Citation:
Liang, Qing-Zhuang,Li, De-Zhi,Wang, Xiao-Lei,et al. Survival Outcome of Squamous Cell Carcinoma Arising from Sinonasal Inverted Papilloma[J]. CHINESE MEDICAL JOURNAL,2015,128(18):2457-2461.
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