北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学临床肿瘤学院  > 期刊论文
学科主题: 临床医学
题名:
Lactobacillus Salivarius REN Inhibits Rat Oral Cancer Induced by 4-Nitroquioline 1-Oxide
作者: Zhang, Ming1; Wang, Fang1; Jiang, Lu1; Liu, Ruihai3; Zhang, Lian2; Lei, Xingen4; Li, Jiyou2; Jiang, Jingli1; Guo, Huiyuan1; Fang, Bing1; Zhao, Liang1; Ren, Fazheng1
刊名: CANCER PREVENTION RESEARCH
发表日期: 2013-07-01
DOI: 10.1158/1940-6207.CAPR-12-0427
卷: 6, 期:7, 页:686-694
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: SQUAMOUS-CELL CARCINOMA ; COLON-CANCER ; TONGUE CARCINOGENESIS ; 4-NITROQUINOLINE 1-OXIDE ; CARDIOVASCULAR RISK ; COX-2 INHIBITORS ; GUT MICROBIOME ; IMMUNE-SYSTEM ; DNA-DAMAGE ; PROBIOTICS
英文摘要:

Despite significant advances in cancer therapy, cancer-related mobility and mortality are still rising. Alternative strategies such as cancer prevention thus become essential. Probiotics represent an emerging option for cancer prevention, but studies are limited to colon cancers. The efficiency of probiotics in the prevention of other cancers and the correlative mechanism remains to be explored. A novel probiotics Lactobacillus salivarius REN (L. salivarius REN) was isolated from centenarians at Bama of China, which showed highly potent antigenotoxicity in an initial assay. 4-nitroquioline 1-oxide (4NQO)-induced oral cancer model was introduced to study the anticancer activity of L. salivarius REN in vivo. The results indicated that oral administration of probiotic L. salivarius REN or its secretions could effectively suppress 4NQO-induced oral carcinogenesis in the initial and postinitial stage, and the inhibition was in a dose-dependent manner. A significant decrease of neoplasm incidence (65%-0%) was detected in rats fed with the high dose of L. salivarius REN [5 x 10(10) CFU/kg body weight (bw)/d]. In vivo evidences indicated that the probiotics inhibited 4NQO-induced oral cancer by protecting DNA against oxidative damage and downregulating COX-2 expression. L. salivarius REN treatment significantly decreased the expression of proliferating cell nuclear antigen (PCNA) and induced apoptosis in a dose-dependent manner. Our findings suggest that probiotics may act as potential agents for oral cancer prevention. This is the first report showing the inhibitory effect of the probiotics on oral carcinogenesis. (c) 2013 AACR.

语种: 英语
所属项目编号: 2011AA100903 ; 2012BAD28B08 ; YB20101001902 ; D101105046010001
项目资助者: Ministry of Science and Technology of China ; Beijing Excellent PHD Thesis Program ; Beijing Science and Technology Project
WOS记录号: WOS:000321195000009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52011
Appears in Collections:北京大学临床肿瘤学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Cornell Univ, Dept Anim Sci, Ithaca, NY 14853 USA
2.China Agr Univ, Key Lab Funct Dairy, Coll Food Sci & Nutr Engn, Beijing 100083, Peoples R China
3.Peking Univ, Dept Food Sci, Canc Hosp, Sch Oncol, Beijing 100871, Peoples R China
4.Peking Univ, Canc Hosp, Sch Oncol, Beijing 100871, Peoples R China

Recommended Citation:
Zhang, Ming,Wang, Fang,Jiang, Lu,et al. Lactobacillus Salivarius REN Inhibits Rat Oral Cancer Induced by 4-Nitroquioline 1-Oxide[J]. CANCER PREVENTION RESEARCH,2013,6(7):686-694.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Zhang, Ming]'s Articles
[Wang, Fang]'s Articles
[Jiang, Lu]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Zhang, Ming]‘s Articles
[Wang, Fang]‘s Articles
[Jiang, Lu]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2018  北京大学医学部 - Feedback
Powered by CSpace