IR@PKUHSC  > 北京大学临床肿瘤学院
学科主题临床医学
Lactobacillus Salivarius REN Inhibits Rat Oral Cancer Induced by 4-Nitroquioline 1-Oxide
Zhang, Ming1; Wang, Fang1; Jiang, Lu1; Liu, Ruihai3; Zhang, Lian2; Lei, Xingen4; Li, Jiyou2; Jiang, Jingli1; Guo, Huiyuan1; Fang, Bing1; Zhao, Liang1; Ren, Fazheng1
刊名CANCER PREVENTION RESEARCH
2013-07-01
DOI10.1158/1940-6207.CAPR-12-0427
6期:7页:686-694
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]SQUAMOUS-CELL CARCINOMA ; COLON-CANCER ; TONGUE CARCINOGENESIS ; 4-NITROQUINOLINE 1-OXIDE ; CARDIOVASCULAR RISK ; COX-2 INHIBITORS ; GUT MICROBIOME ; IMMUNE-SYSTEM ; DNA-DAMAGE ; PROBIOTICS
英文摘要

Despite significant advances in cancer therapy, cancer-related mobility and mortality are still rising. Alternative strategies such as cancer prevention thus become essential. Probiotics represent an emerging option for cancer prevention, but studies are limited to colon cancers. The efficiency of probiotics in the prevention of other cancers and the correlative mechanism remains to be explored. A novel probiotics Lactobacillus salivarius REN (L. salivarius REN) was isolated from centenarians at Bama of China, which showed highly potent antigenotoxicity in an initial assay. 4-nitroquioline 1-oxide (4NQO)-induced oral cancer model was introduced to study the anticancer activity of L. salivarius REN in vivo. The results indicated that oral administration of probiotic L. salivarius REN or its secretions could effectively suppress 4NQO-induced oral carcinogenesis in the initial and postinitial stage, and the inhibition was in a dose-dependent manner. A significant decrease of neoplasm incidence (65%-0%) was detected in rats fed with the high dose of L. salivarius REN [5 x 10(10) CFU/kg body weight (bw)/d]. In vivo evidences indicated that the probiotics inhibited 4NQO-induced oral cancer by protecting DNA against oxidative damage and downregulating COX-2 expression. L. salivarius REN treatment significantly decreased the expression of proliferating cell nuclear antigen (PCNA) and induced apoptosis in a dose-dependent manner. Our findings suggest that probiotics may act as potential agents for oral cancer prevention. This is the first report showing the inhibitory effect of the probiotics on oral carcinogenesis. (c) 2013 AACR.

语种英语
WOS记录号WOS:000321195000009
项目编号2011AA100903 ; 2012BAD28B08 ; YB20101001902 ; D101105046010001
资助机构Ministry of Science and Technology of China ; Beijing Excellent PHD Thesis Program ; Beijing Science and Technology Project
引用统计
被引频次:20[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52011
专题北京大学临床肿瘤学院
作者单位1.Cornell Univ, Dept Anim Sci, Ithaca, NY 14853 USA
2.China Agr Univ, Key Lab Funct Dairy, Coll Food Sci & Nutr Engn, Beijing 100083, Peoples R China
3.Peking Univ, Dept Food Sci, Canc Hosp, Sch Oncol, Beijing 100871, Peoples R China
4.Peking Univ, Canc Hosp, Sch Oncol, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Ming,Wang, Fang,Jiang, Lu,et al. Lactobacillus Salivarius REN Inhibits Rat Oral Cancer Induced by 4-Nitroquioline 1-Oxide[J]. CANCER PREVENTION RESEARCH,2013,6(7):686-694.
APA Zhang, Ming.,Wang, Fang.,Jiang, Lu.,Liu, Ruihai.,Zhang, Lian.,...&Ren, Fazheng.(2013).Lactobacillus Salivarius REN Inhibits Rat Oral Cancer Induced by 4-Nitroquioline 1-Oxide.CANCER PREVENTION RESEARCH,6(7),686-694.
MLA Zhang, Ming,et al."Lactobacillus Salivarius REN Inhibits Rat Oral Cancer Induced by 4-Nitroquioline 1-Oxide".CANCER PREVENTION RESEARCH 6.7(2013):686-694.
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