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学科主题: 公共卫生
题名:
An essential role for TAK1 in the contact hypersensitivity response
作者: Zhao, Yan G.1,2; Wang, Yunqi1; Hao, Weidong2; Wan, Yisong Y.1
关键词: CHS ; DC ; 2,4-dinitrofluorobenzene (DNFB) ; TAK1
刊名: CELLULAR & MOLECULAR IMMUNOLOGY
发表日期: 2011-07-01
DOI: 10.1038/cmi.2011.11
卷: 8, 期:4, 页:315-324
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Immunology
研究领域[WOS]: Immunology
关键词[WOS]: NF-KAPPA-B ; CD8(+) T-CELLS ; ADAPTIVE IMMUNE-RESPONSES ; KINASE TAK1 ; KERATINOCYTE APOPTOSIS ; RHEUMATOID-ARTHRITIS ; SKIN INFLAMMATION ; EFFECTOR-CELLS ; TGF-BETA ; DERMATITIS
英文摘要:

Contact hypersensitivity (CHS) is a delayed-type hypersensitivity that can be induced by haptens, such as 2,4-dinitrofluorobenzene (DNFB). Innate and adaptive immunities are both important for the development of CHS. To treat CHS-related diseases, such as allergic contact dermatitis, a disease prevalent in industrialized countries, ways of interfering with improper immune function during CHS responses need to be identified. Transforming growth factor-beta-activated kinase-1 (TAK1), a member of mitogen-activated protein kinase kinase kinase family, is important for both innate and adaptive immunities. We thus hypothesized that the CHS response could be inhibited by interfering with TAK1 activity. Using a mouse model in which TAK1 deletion can be locally induced, we observed that TAK deficiency led to an impaired CHS response and was associated with defective T-cell expansion, activation and interferon (IFN)-gamma production. In addition, we investigated the effect of deleting TAK1 specifically in dendritic cells (DC) on the CHS response. We found that when TAK1 is deficient in DC, the CHS response was abolished and hapten-elicited T-cell responses were defective. Collectively, this study demonstrates an essential role of TAK1 in the induction of CHS and suggests that targeting TAK1 could be a viable approach to treat CHS. Cellular & Molecular Immunology (2011) 8, 315-324; doi: 10.1038/cmi.2011.11; published online 9 May 2011

语种: 英语
所属项目编号: R00AI072956 ; 7082054 ; 2009ZX09301-010
项目资助者: National Institutes of Health ; Beijing Natural Science Foundation ; National Science and Technology Major Specific Project of the People&prime ; s Republic of China ; China Scholarship Council
WOS记录号: WOS:000292320800006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52015
Appears in Collections:北京大学公共卫生学院_毒理学系_期刊论文

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作者单位: 1.Univ N Carolina, Dept Microbiol & Immunol, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA
2.Peking Univ, Sch Publ Hlth, Dept Toxicol, Beijing 100191, Peoples R China

Recommended Citation:
Zhao, Yan G.,Wang, Yunqi,Hao, Weidong,et al. An essential role for TAK1 in the contact hypersensitivity response[J]. CELLULAR & MOLECULAR IMMUNOLOGY,2011,8(4):315-324.
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