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学科主题临床医学
MicroRNA-205 promotes the tumorigenesis of nasopharyngeal carcinoma through targeting tumor protein p53-inducible nuclear protein 1
Nie, Guohui1; Duan, Hongfang1,2; Li, Xiaoqing3,4; Yu, Zhendong5; Luo, Liang1,2; Lu, Ruijing3,4; Ji, Ziliang4; Zhang, Wei6
关键词Nasopharyngeal Carcinoma Microrna-205 Tumor Promoter Tumor Protein P53-inducible Nuclear Protein 1
刊名MOLECULAR MEDICINE REPORTS
2015-10-01
DOI10.3892/mmr.2015.4181
12期:4页:5715-5722
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Medicine, Research & Experimental
研究领域[WOS]Oncology ; Research & Experimental Medicine
关键词[WOS]SQUAMOUS-CELL CARCINOMA ; BREAST-CANCER ; PROSTATE-CANCER ; MESSENGER-RNA ; PROLIFERATION ; EXPRESSION ; APOPTOSIS ; P53 ; INVASION ; MIR-155
英文摘要

Nasopharyngeal carcinoma (NPC) is a common type of cancer in southern China, miRNAs have been shown to be involved in the tumorigenesis of multiple cancer types. The present study aimed to explore the potential role of miR-205 in NPC. Reverse transcription quantitative polymerase chain reaction was used to determine the expression levels of miR-205 in 20 fresh NPC specimens and 20 normal nasopharyngeal tissues. The function of miR-205 in the proliferation, migration, invasion and apoptosis of NPC-derived cells was detected by MTT assay, colony formation assay, wound healing assay, Transwell assay and flow cytometry. Furthermore, a target gene of miR-205 was identified using the luciferase reporter assay. The expression of miR-205 was increased in NPC tissues compared with that in normal tissues. Overexpression of miR-205 was found to promote the proliferation, migration and invasion of NPC-derived cells, while apoptosis was suppressed. Tumor protein p53-inducible nuclear protein 1 was identified as a target gene of miR-205. Overall, the present study demonstrated that miR-205 may function as an oncogene in NPC tumorigenesis.

语种英语
WOS记录号WOS:000362999300016
项目编号JCYJ20120827150357364 ; JCYJ20130402114702127 ; 201302005
资助机构Science and Technology Development Fund Project of Shenzhen ; Medical Research Project of Health and Family Planning Commission of Shenzhen
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52017
专题北京大学深圳医院_耳鼻咽喉科
北京大学第一临床医学院_小儿眼科
作者单位1.Peking Univ, Shenzhen Hosp, Dept Otolaryngol, Shenzhen 518036, Guangdong, Peoples R China
2.Guangzhou Med Univ, Dept Clin Med, Guangzhou 510000, Guangdong, Peoples R China
3.Peking Univ, Shenzhen Hosp, Dept Clin Lab, Shenzhen 518036, Guangdong, Peoples R China
4.Shantou Univ, Coll Med, Dept Clin Med, Shantou 515041, Guangdong, Peoples R China
5.Peking Univ, Shenzcien Hosp, Cent Lab, Shenzhen 518036, Guangdong, Peoples R China
6.Hong Kong Univ Sci & Technol, Shenzhen Peking Univ, Shenzhen Key Lab Translat Med Dermatol, Biomed Res Inst,Med Ctr, Shenzhen 518036, Guangdong, Peoples R China
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GB/T 7714
Nie, Guohui,Duan, Hongfang,Li, Xiaoqing,et al. MicroRNA-205 promotes the tumorigenesis of nasopharyngeal carcinoma through targeting tumor protein p53-inducible nuclear protein 1[J]. MOLECULAR MEDICINE REPORTS,2015,12(4):5715-5722.
APA Nie, Guohui.,Duan, Hongfang.,Li, Xiaoqing.,Yu, Zhendong.,Luo, Liang.,...&Zhang, Wei.(2015).MicroRNA-205 promotes the tumorigenesis of nasopharyngeal carcinoma through targeting tumor protein p53-inducible nuclear protein 1.MOLECULAR MEDICINE REPORTS,12(4),5715-5722.
MLA Nie, Guohui,et al."MicroRNA-205 promotes the tumorigenesis of nasopharyngeal carcinoma through targeting tumor protein p53-inducible nuclear protein 1".MOLECULAR MEDICINE REPORTS 12.4(2015):5715-5722.
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