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学科主题: 基础医学
题名:
Effects of glucose, insulin, and supernatant from pancreatic beta-cells on brain-pancreas relative protein in rat hippocampus
作者: Lin, Yan-Hua1; Westenbroek, Christel1; Tie, Lu1; Liu, Ai-Hua1; Yu, He-Ming1; Ter Horst, Gert J.1; Li, Xue-Jun1
关键词: brain-pancreas relative protein ; pancreatic beta-cells ; hippocampal neurons ; insulin ; glucose ; diabetes
刊名: NEUROCHEMICAL RESEARCH
发表日期: 2006-12-01
DOI: 10.1007/s11064-006-9193-9
卷: 31, 期:12, 页:1417-1424
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Neurosciences
研究领域[WOS]: Biochemistry & Molecular Biology ; Neurosciences & Neurology
关键词[WOS]: CENTRAL-NERVOUS-SYSTEM ; DIABETIC CHINESE-HAMSTER ; RECEPTORS ; CNS ; PHOSPHORYLATION ; LOCALIZATION ; HYPOGLYCEMIA ; SURVIVAL ; MELLITUS ; LESIONS
英文摘要:

Brain-pancreas relative protein (BPRP) is a novel protein that mainly expresses in brain and pancreas. In our previous study, we found that various stressors significantly decreased the expression of BPRP in pancreas in vivo, accompanied by changes in insulin and glucose levels, and that expression of BPRP in pancreas also decreased significantly in diabetic rats induced by Streptozocin (STZ). All these findings suggest that BPRP may be a glucose or insulin-sensitive protein. However, how the changes in insulin or glucose levels influence the expression of BPRP in hippocampus requires further study. Here, we investigated the effects of insulin or glucose on the expression of BPRP in primary cultured hippocampal neurons. We supplied hippocampal neurons with glucose, insulin, or supernatant from pancreatic beta-cells, which secrete insulin into the supernatant. Our data showed that insulin had beneficial effect on the viability while no significant effect on the expression of BPRP in hippocampal neurons. On the contrary, 40 mM glucose or free glucose culture significantly decreased the expression of BPRP, while had no significant effect on the viability and apoptosis of hippocampal neurons. Further study showed that levels of insulin in the supernatant collected from pancreatic beta-cells medium changed over days, and that supernatant increased the viability of hippocampal neurons, while it had no obvious effect on the expression of BPRP in hippocampal neurons. These results suggest that BPRP may be a glucose-sensitive protein.

语种: 英语
WOS记录号: WOS:000242465000003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52020
Appears in Collections:基础医学院_药理学系_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Dept Pharmacol, Sch Basic Med Sci, Beijing 100083, Peoples R China
2.Peking Univ, Hlth Sci Ctr, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
3.Univ Groningen, Dept Psychiat, Grad Sch Behav & Cognit Neurosci, NL-9700 RB Groningen, Netherlands
4.Peking Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
5.Natl Res Inst Family Planning, Beijing 100081, Peoples R China

Recommended Citation:
Lin, Yan-Hua,Westenbroek, Christel,Tie, Lu,et al. Effects of glucose, insulin, and supernatant from pancreatic beta-cells on brain-pancreas relative protein in rat hippocampus[J]. NEUROCHEMICAL RESEARCH,2006,31(12):1417-1424.
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