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学科主题: 基础医学
题名:
Antidepressant effects of curcumin in the forced swim test and olfactory bulbectomy models of depression in rats
作者: Xu, Y; Ku, BS; Yao, HY; Lin, YH; Ma, X; Zhang, YH; Li, XJ
关键词: curcumin ; antidepressant ; forced swimming ; olfactory bulbectomy ; open field ; passive avoidance ; brain monoamines ; rats
刊名: PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
发表日期: 2005-09-01
DOI: 10.1016/j.pbb.2005.08.009
卷: 82, 期:1, 页:200-206
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Behavioral Sciences ; Neurosciences ; Pharmacology & Pharmacy
研究领域[WOS]: Behavioral Sciences ; Neurosciences & Neurology ; Pharmacology & Pharmacy
关键词[WOS]: BRAIN ; DESIPRAMINE ; BEHAVIOR ; CELLS ; ZINC
英文摘要:

Curcuma longa is a major constituent of Xiaoyao-san, the traditional Chinese medicinal formula, which has been used to effectively manage stress and depression-related disorders in China. Curcumin is the active component of curcuma longa, and we hypothesized that curcumin would have an influence on depressive-like behaviors. The purpose of the present study was to confirm the putative antidepressant effect of chronic administrations of curcumin (1.25, 2.5, 5 and 10 mg/kg, p.o.) in the forced swimming test and bilateral olfactory bulbectomy (OB) models of depression in rats. In the first study, chronic treatment with curcumin (14 days) reduced the immobility time in the forced swimming test. In the second experiment, curcumin reversed the OB-induced behavioral abnormalities such as hyperactivity in the open field, as well as deficits in step-down passive avoidance. In addition, OB-induced low levels of serotonin (5-HT), noradrenaline (NA), high 5-hydroxyindoleacetic acid (5-HIAA) and 4-dihydroxyphenylacetic acid (DOPAC) in the hippocampus were observed, and were completely reversed by curcumin administration. A slight decrease in 5-HT, NA and dopamine (DA) levels was found in the frontal cortex of OB rats which was also reversed by curcumin treatment. These results confirm the antidepressant effects of curcumin in the forced swim and the OB models of depression ill rats, and suggest that these antidepressant effects may be mediated by actions in the central monoaminergic neurotransmitter systems. (c) 2005 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000232812600025
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52022
Appears in Collections:基础医学院_药理学系_期刊论文

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作者单位: Peking Univ, Sch Basic Med Sci, Dept Pharmacol, Beijing, Peoples R China

Recommended Citation:
Xu, Y,Ku, BS,Yao, HY,et al. Antidepressant effects of curcumin in the forced swim test and olfactory bulbectomy models of depression in rats[J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,2005,82(1):200-206.
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