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Polygenic transmission and complex neuro developmental network for attention deficit hyperactivity disorder: Genome-wide association study of both common and rare variants
Yang, Li1,2; Neale, Benjamin M.3,4; Liu, Lu1,2; Lee, S. Hong5; Wray, Naomi R.5; Ji, Ning1,2; Li, Haimei1,2; Qian, Qiujin1,2; Wang, Dongliang6; Li, Jun7; Faraone, Stephen V.6; Wang, Yufeng1,2; Psychiat GWAS Consortium ADHD1
关键词Adhd Gwas Pathway Neurodevelopment
刊名AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
2013-07-01
DOI10.1002/ajmg.b.32169
162B期:5页:419-430
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Genetics & Heredity ; Psychiatry
研究领域[WOS]Genetics & Heredity ; Psychiatry
关键词[WOS]DEFICIT/HYPERACTIVITY DISORDER ; BIPOLAR DISORDER ; SCHIZOPHRENIA ; LINKAGE ; GENE ; POLYMORPHISM ; METAANALYSIS ; SCAN ; ADHD ; DUPLICATIONS
英文摘要

Attention-deficit hyperactivity disorder (ADHD) is a complex polygenic disorder. This study aimed to discover common and rare DNA variants associated with ADHD in a large homogeneous Han Chinese ADHD case-control sample. The sample comprised 1,040 cases and 963 controls. All cases met DSM-IV ADHD diagnostic criteria. We used the Affymetrix6.0 array to assay both single nucleotide polymorphisms (SNPs) and copy number variants (CNVs). Genome-wide association analyses were performed using PLINK. SNP-heritability and SNP-genetic correlations with ADHD in Caucasians were estimated with genome-wide complex trait analysis (GCTA). Pathway analyses were performed using the Interval enRICHment Test (INRICH), the Disease Association Protein-Protein Link Evaluator (DAPPLE), and the Genomic Regions Enrichment of Annotations Tool (GREAT). We did not find genome-wide significance for single SNPs but did find an increased burden of large, rare CNVs in the ADHD sample (P=0.038). SNP-heritability was estimated to be 0.42 (standard error, 0.13, P=0.0017) and the SNP-genetic correlation with European Ancestry ADHD samples was 0.39 (SE 0.15, P=0.0072). The INRICH, DAPPLE, and GREAT analyses implicated several gene ontology cellular components, including neuron projections and synaptic components, which are consistent with a neurodevelopmental pathophysiology for ADHD. This study suggested the genetic architecture of ADHD comprises both common and rare variants. Some common causal variants are likely to be shared between Han Chinese and Caucasians. Complex neurodevelopmental networks may underlie ADHD′s etiology. (c) 2013 Wiley Periodicals, Inc.

语种英语
WOS记录号WOS:000320549100001
项目编号30800302 ; 81071109 ; 200802073 ; NCET-11-0013 ; 2007BAI17B03 ; R13MH059126 ; R01MH62873 ; U01MH085518 ; R01MH081803 ; U01MH085515 ; K23MH066275-01 ; R01MH58277 ; FT0991360 ; 1011506 ; 1047956 ; 443036 ; KFO 125 ; SFB 581 ; GRK 1156 ; ME 1923/5-1 ; ME 1923/5-3 ; GRK 1389 ; BMBF 01GV0605 ; MOP 64277 ; 44070 ; 74699 ; SCHA 542/10-3
资助机构National Natural Science Foundation of China ; Chinese Ministry of Health ; Ministry of Education Program for New Century Excellent Talents in University ; Ministry of Science and Technology ; National Institute of Health ; Australian Research council ; Australian National Health and Medical Research Council ; Children&prime ; s Hospital of Philadelphia ; Affymetrix Power Award ; Sidney Sax Public Health Fellowship ; Wellcome Trust, UK ; UMC Utrecht Genvlag Grant ; Radboud University ; Nijmegen Medical Centre ; Deutsche Forschungsgemeinschaft ; BundesministeriumfurBildung und Forschung ; Canadian Institutes of Health Research
引用统计
被引频次:71[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52026
专题北京大学精神卫生研究所
北京大学精神卫生研究所_精神科
作者单位1.Minist Hlth, Key Lab Mental Hlth, Beijing, Peoples R China
2.Peking Univ Sixth Hosp, Inst Mental Hlth, Beijing 100191, Peoples R China
3.Broad Inst Harvard & MIT, Cambridge, MA USA
4.Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA
5.Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia
6.SUNY Upstate Med Univ, Dept Psychiat & Behav Sci, Syracuse, NY 13210 USA
7.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China
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GB/T 7714
Yang, Li,Neale, Benjamin M.,Liu, Lu,et al. Polygenic transmission and complex neuro developmental network for attention deficit hyperactivity disorder: Genome-wide association study of both common and rare variants[J]. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS,2013,162B(5):419-430.
APA Yang, Li.,Neale, Benjamin M..,Liu, Lu.,Lee, S. Hong.,Wray, Naomi R..,...&Psychiat GWAS Consortium ADHD.(2013).Polygenic transmission and complex neuro developmental network for attention deficit hyperactivity disorder: Genome-wide association study of both common and rare variants.AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS,162B(5),419-430.
MLA Yang, Li,et al."Polygenic transmission and complex neuro developmental network for attention deficit hyperactivity disorder: Genome-wide association study of both common and rare variants".AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS 162B.5(2013):419-430.
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