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Chronic green tea catechins administration prevents oxidative stress-related brain aging in C57BL/6J mice
Li, Qiong1; Zhao, Haifeng2; Zhao, Ming1; Zhang, Zhaofeng1; Li, Yong1
关键词Green Tea Catechins Aging Oxidative Stress
刊名BRAIN RESEARCH
2010-09-24
DOI10.1016/j.brainres.2010.07.074
1353页:28-35
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
资助者Ministry of Science and Technology of the People&prime ; s Republic of China ; Ministry of Science and Technology of the People&prime ; s Republic of China
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]NF-KAPPA-B ; SPATIAL-LEARNING IMPAIRMENTS ; RAT-BRAIN ; RECEPTOR SUBUNITS ; AGED MICE ; NEURODEGENERATIVE DISEASES ; TRANSCRIPTION FACTORS ; NERVOUS-SYSTEM ; GRAPE JUICE ; LIPOFUSCIN
英文摘要

As the organism ages, production of reactive oxygen species (ROS) increases while antioxidants defense capability declines, leading to oxidative stress in critical cellular components, which further enhances ROS production. In the brain, this vicious cycle is more severe as brain is particularly vulnerable to oxidative damage. In our study, 14-month-old female C57BL/6J mice were orally administered 0.05% green tea catechins (GTC, w/v) in drinking water for 6 months. We found that GTC supplementation prevented the decrease in total superoxide dismutase and glutathione peroxidase activities in serum as well as reduced the thiobarbituric acid reactive substances and protein carbonyl contents in the hippocampus of aged mice. The activation of transcriptional factor nuclear factor-kappa B and lipofuscin formation in pyramidal cells of hippocampal CA1 region, which are all related to oxidative stress, was also reduced after GTC treatment. We also found that long-term GTC treatment prevented age-related reductions of two representative post-synaptic proteins post-synaptic density 95 and N-methyl-D-aspartate receptor 1 in the hippocampus. These results demonstrated that chronic 0.05% green tea catechins administration may prevent oxidative stress related brain aging in female C57BL/6J mice. (C) 2010 Elsevier B.V. All rights reserved.

语种英语
所属项目编号2006BAD27B08
资助者Ministry of Science and Technology of the People&prime ; s Republic of China ; Ministry of Science and Technology of the People&prime ; s Republic of China
WOS记录号WOS:000282419500003
引用统计
被引频次:20[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52031
专题北京大学公共卫生学院
作者单位1.Peking Univ, Dept Nutr & Food Hyg, Sch Publ Hlth, Beijing 100191, Peoples R China
2.Shanxi Med Univ, Dept Nutr & Food Hyg, Sch Publ Hlth, Taiyuan 030001, Shanxi, Peoples R China
推荐引用方式
GB/T 7714
Li, Qiong,Zhao, Haifeng,Zhao, Ming,et al. Chronic green tea catechins administration prevents oxidative stress-related brain aging in C57BL/6J mice[J]. BRAIN RESEARCH,2010,1353:28-35.
APA Li, Qiong,Zhao, Haifeng,Zhao, Ming,Zhang, Zhaofeng,&Li, Yong.(2010).Chronic green tea catechins administration prevents oxidative stress-related brain aging in C57BL/6J mice.BRAIN RESEARCH,1353,28-35.
MLA Li, Qiong,et al."Chronic green tea catechins administration prevents oxidative stress-related brain aging in C57BL/6J mice".BRAIN RESEARCH 1353(2010):28-35.
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