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学科主题: 公共卫生
题名:
Chronic green tea catechins administration prevents oxidative stress-related brain aging in C57BL/6J mice
作者: Li, Qiong1; Zhao, Haifeng2; Zhao, Ming1; Zhang, Zhaofeng1; Li, Yong1
关键词: Green tea catechins ; Aging ; Oxidative stress
刊名: BRAIN RESEARCH
发表日期: 2010-09-24
DOI: 10.1016/j.brainres.2010.07.074
卷: 1353, 页:28-35
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: NF-KAPPA-B ; SPATIAL-LEARNING IMPAIRMENTS ; RAT-BRAIN ; RECEPTOR SUBUNITS ; AGED MICE ; NEURODEGENERATIVE DISEASES ; TRANSCRIPTION FACTORS ; NERVOUS-SYSTEM ; GRAPE JUICE ; LIPOFUSCIN
英文摘要:

As the organism ages, production of reactive oxygen species (ROS) increases while antioxidants defense capability declines, leading to oxidative stress in critical cellular components, which further enhances ROS production. In the brain, this vicious cycle is more severe as brain is particularly vulnerable to oxidative damage. In our study, 14-month-old female C57BL/6J mice were orally administered 0.05% green tea catechins (GTC, w/v) in drinking water for 6 months. We found that GTC supplementation prevented the decrease in total superoxide dismutase and glutathione peroxidase activities in serum as well as reduced the thiobarbituric acid reactive substances and protein carbonyl contents in the hippocampus of aged mice. The activation of transcriptional factor nuclear factor-kappa B and lipofuscin formation in pyramidal cells of hippocampal CA1 region, which are all related to oxidative stress, was also reduced after GTC treatment. We also found that long-term GTC treatment prevented age-related reductions of two representative post-synaptic proteins post-synaptic density 95 and N-methyl-D-aspartate receptor 1 in the hippocampus. These results demonstrated that chronic 0.05% green tea catechins administration may prevent oxidative stress related brain aging in female C57BL/6J mice. (C) 2010 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 2006BAD27B08
项目资助者: Ministry of Science and Technology of the People&prime ; s Republic of China
WOS记录号: WOS:000282419500003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52031
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Peking Univ, Dept Nutr & Food Hyg, Sch Publ Hlth, Beijing 100191, Peoples R China
2.Shanxi Med Univ, Dept Nutr & Food Hyg, Sch Publ Hlth, Taiyuan 030001, Shanxi, Peoples R China

Recommended Citation:
Li, Qiong,Zhao, Haifeng,Zhao, Ming,et al. Chronic green tea catechins administration prevents oxidative stress-related brain aging in C57BL/6J mice[J]. BRAIN RESEARCH,2010,1353:28-35.
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