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学科主题临床医学
Autologous peripheral blood stem cell transplantation in the patients with hematologic malignancies and solid tumors
Ke, XY; Yang, YH; Zhao, X; Wang, LX
关键词Autologous Peripheral Blood Stem Cell Transplantation Disease-free Survival Overall Survival
刊名CHINESE MEDICAL JOURNAL
2001-02-01
114期:2页:196-199
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
英文摘要

Objective To evaluate the long-term therapeutic effects of autologous peripheral blood stem cell transplantation (auto-PBSCT) on the treatment of hematological and solid tumors.

Methods Fifty-one patients were recruited in this auto-PBSCT study, in which several potentially important parameters were studied including the optimal time for stem cell collection, the dose of stem cell reinfusion, the time of hematopoietic reconstitution, the disease free survival (DFS) and overall survival (OS), complications related to transplantation, and maintenance chemotherapy after auto-PBSCT.

Results After APBSCT, 3-year and 5-year survival rates of NHL were 83.3%; those of AML were 74.7%; those of MM were 37.9% and 19%; those of ALL were 40% and 0% respectively. Hematopoietic reconstitution was greatly promoted by granulocyte colony stimulating factor (G-CSF). The mean time for patients′ neutrophil to recover up to > 0.5 x 10(9)/L after APBSCT was 11.14 days in the group of the patients receiving G-CSF in contrast to 17.6 days in the group receiving no G-CSF. The most common complications of transplantation were fever, liver dysfunction and hypokalaemia, which were curable. No death was due to transplantation related complications.

Conclusion Comparing with conventional chemotherapy, our study suggests that auto-PBSCT is a very important therapeutic option that can significantly improve the prognosis in the patients with hematological and solid tumors, especially in the patients with AML and NHL.

语种英语
WOS记录号WOS:000167246700020
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被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52052
专题北京大学第三临床医学院_血液内科
作者单位Peking Univ, Sch Med, Hosp 3, Dept Hematol, Beijing 100083, Peoples R China
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Ke, XY,Yang, YH,Zhao, X,et al. Autologous peripheral blood stem cell transplantation in the patients with hematologic malignancies and solid tumors[J]. CHINESE MEDICAL JOURNAL,2001,114(2):196-199.
APA Ke, XY,Yang, YH,Zhao, X,&Wang, LX.(2001).Autologous peripheral blood stem cell transplantation in the patients with hematologic malignancies and solid tumors.CHINESE MEDICAL JOURNAL,114(2),196-199.
MLA Ke, XY,et al."Autologous peripheral blood stem cell transplantation in the patients with hematologic malignancies and solid tumors".CHINESE MEDICAL JOURNAL 114.2(2001):196-199.
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