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IR@PKUHSC  > 北京大学第三临床医学院  > 血液内科  > 期刊论文
学科主题: 临床医学
题名:
Autologous peripheral blood stem cell transplantation in the patients with hematologic malignancies and solid tumors
作者: Ke, XY; Yang, YH; Zhao, X; Wang, LX
关键词: autologous peripheral blood stem cell transplantation ; disease-free survival ; overall survival
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2001-02-01
卷: 114, 期:2, 页:196-199
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
英文摘要:

Objective To evaluate the long-term therapeutic effects of autologous peripheral blood stem cell transplantation (auto-PBSCT) on the treatment of hematological and solid tumors.

Methods Fifty-one patients were recruited in this auto-PBSCT study, in which several potentially important parameters were studied including the optimal time for stem cell collection, the dose of stem cell reinfusion, the time of hematopoietic reconstitution, the disease free survival (DFS) and overall survival (OS), complications related to transplantation, and maintenance chemotherapy after auto-PBSCT.

Results After APBSCT, 3-year and 5-year survival rates of NHL were 83.3%; those of AML were 74.7%; those of MM were 37.9% and 19%; those of ALL were 40% and 0% respectively. Hematopoietic reconstitution was greatly promoted by granulocyte colony stimulating factor (G-CSF). The mean time for patients′ neutrophil to recover up to > 0.5 x 10(9)/L after APBSCT was 11.14 days in the group of the patients receiving G-CSF in contrast to 17.6 days in the group receiving no G-CSF. The most common complications of transplantation were fever, liver dysfunction and hypokalaemia, which were curable. No death was due to transplantation related complications.

Conclusion Comparing with conventional chemotherapy, our study suggests that auto-PBSCT is a very important therapeutic option that can significantly improve the prognosis in the patients with hematological and solid tumors, especially in the patients with AML and NHL.

语种: 英语
WOS记录号: WOS:000167246700020
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52052
Appears in Collections:北京大学第三临床医学院_血液内科_期刊论文

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作者单位: Peking Univ, Sch Med, Hosp 3, Dept Hematol, Beijing 100083, Peoples R China

Recommended Citation:
Ke, XY,Yang, YH,Zhao, X,et al. Autologous peripheral blood stem cell transplantation in the patients with hematologic malignancies and solid tumors[J]. CHINESE MEDICAL JOURNAL,2001,114(2):196-199.
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