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学科主题: 临床医学
题名:
Association of C3 Gene Polymorphisms with Neovascular Age-Related Macular Degeneration in a Chinese Population
作者: Pei, Xue-Ting; Li, Xiao-Xin; Bao, Yong-Zhen; Yu, Wen-Zhen; Yan, Zheng; Qi, Hui-Jun; Qian, Tong; Xiao, Hong-Xiang
关键词: age-related macular degeneration ; Chinese ; complement factor 3 ; polymorphism
刊名: CURRENT EYE RESEARCH
发表日期: 2009
DOI: 10.1080/02713680903003484
卷: 34, 期:8, 页:615-622
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Ophthalmology
研究领域[WOS]: Ophthalmology
关键词[WOS]: FACTOR-H POLYMORPHISM ; FACTOR-B ; RISK ; VARIANT ; Y402H ; MACULOPATHY ; INCREASES ; DISEASE ; EYE
英文摘要:

Purpose: The purpose of this study was to determine whether the genetic polymorphisms of complement factor 3 (C3) are associated with neovascular age-related macular degeneration (AMD) in the Chinese population. Methods: A total of 123 unrelated Chinese Han patients with neovascular AMD and 130 control subjects were recruited. Their six single-nucleotide polymorphisms (SNPs) in the C3 gene, one in the complement factor H (CFH) gene and two in the complement factor B (CFB) gene were characterized. Their genotypes, allele frequencies, and odds ratios were analyzed. Results: The G allele of the C3 IVS2 rs2250656, but not other tested C3 SNPs of rs2230205, rs10411506, rs2230199, rs339392, and rs163913, was significantly associated with a reduced risk for AMD in the Chinese population (OR 0.605, 95% CI 0.39-0.93, p = 0.023), even after adjusting for age, gender, smoking status, CFH rs1061170, CFB rs4151667, and CFB rs641153 allele status (OR 0.58, 95% CI 0.35-0.96, p = 0.033). However, the C3 haplotype of A-A-C-A-T-T was identified as a statistically significant risk factor for neovascular AMD (OR 1.41, 95% CI 1.02-1.94). Furthermore, the C allele of the CFH rs1061170, but not the CFB rs4151667 and rs641153, was significnatly associated with increased risk for AMD (OR 3.09, 95% CI 1.55-6.15, p < 0.001). Conclusion: The G allele of C3 IVS2 rs2250656 may be a significantly protective factor for neovascular AMD in the Chinese population. This, together with low MAF of C3 R102G, may be partially responsible for the low prevalence of AMD in the Chinese population.

语种: 英语
WOS记录号: WOS:000268882000001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52054
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: Peking Univ, People Eye Ctr, Peoples Hosp, Beijing 100044, Peoples R China

Recommended Citation:
Pei, Xue-Ting,Li, Xiao-Xin,Bao, Yong-Zhen,et al. Association of C3 Gene Polymorphisms with Neovascular Age-Related Macular Degeneration in a Chinese Population[J]. CURRENT EYE RESEARCH,2009,34(8):615-622.
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