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学科主题临床医学
Association of C3 Gene Polymorphisms with Neovascular Age-Related Macular Degeneration in a Chinese Population
Pei, Xue-Ting; Li, Xiao-Xin; Bao, Yong-Zhen; Yu, Wen-Zhen; Yan, Zheng; Qi, Hui-Jun; Qian, Tong; Xiao, Hong-Xiang
关键词Age-related Macular Degeneration Chinese Complement Factor 3 Polymorphism
刊名CURRENT EYE RESEARCH
2009
DOI10.1080/02713680903003484
34期:8页:615-622
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Ophthalmology
研究领域[WOS]Ophthalmology
关键词[WOS]FACTOR-H POLYMORPHISM ; FACTOR-B ; RISK ; VARIANT ; Y402H ; MACULOPATHY ; INCREASES ; DISEASE ; EYE
英文摘要

Purpose: The purpose of this study was to determine whether the genetic polymorphisms of complement factor 3 (C3) are associated with neovascular age-related macular degeneration (AMD) in the Chinese population. Methods: A total of 123 unrelated Chinese Han patients with neovascular AMD and 130 control subjects were recruited. Their six single-nucleotide polymorphisms (SNPs) in the C3 gene, one in the complement factor H (CFH) gene and two in the complement factor B (CFB) gene were characterized. Their genotypes, allele frequencies, and odds ratios were analyzed. Results: The G allele of the C3 IVS2 rs2250656, but not other tested C3 SNPs of rs2230205, rs10411506, rs2230199, rs339392, and rs163913, was significantly associated with a reduced risk for AMD in the Chinese population (OR 0.605, 95% CI 0.39-0.93, p = 0.023), even after adjusting for age, gender, smoking status, CFH rs1061170, CFB rs4151667, and CFB rs641153 allele status (OR 0.58, 95% CI 0.35-0.96, p = 0.033). However, the C3 haplotype of A-A-C-A-T-T was identified as a statistically significant risk factor for neovascular AMD (OR 1.41, 95% CI 1.02-1.94). Furthermore, the C allele of the CFH rs1061170, but not the CFB rs4151667 and rs641153, was significnatly associated with increased risk for AMD (OR 3.09, 95% CI 1.55-6.15, p < 0.001). Conclusion: The G allele of C3 IVS2 rs2250656 may be a significantly protective factor for neovascular AMD in the Chinese population. This, together with low MAF of C3 R102G, may be partially responsible for the low prevalence of AMD in the Chinese population.

语种英语
WOS记录号WOS:000268882000001
引用统计
被引频次:28[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52054
专题北京大学第二临床医学院
作者单位Peking Univ, People Eye Ctr, Peoples Hosp, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Pei, Xue-Ting,Li, Xiao-Xin,Bao, Yong-Zhen,et al. Association of C3 Gene Polymorphisms with Neovascular Age-Related Macular Degeneration in a Chinese Population[J]. CURRENT EYE RESEARCH,2009,34(8):615-622.
APA Pei, Xue-Ting.,Li, Xiao-Xin.,Bao, Yong-Zhen.,Yu, Wen-Zhen.,Yan, Zheng.,...&Xiao, Hong-Xiang.(2009).Association of C3 Gene Polymorphisms with Neovascular Age-Related Macular Degeneration in a Chinese Population.CURRENT EYE RESEARCH,34(8),615-622.
MLA Pei, Xue-Ting,et al."Association of C3 Gene Polymorphisms with Neovascular Age-Related Macular Degeneration in a Chinese Population".CURRENT EYE RESEARCH 34.8(2009):615-622.
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