IR@PKUHSC  > 北京大学深圳医院
学科主题临床医学
Multilayered molecular profiling supported the monoclonal origin of metastatic renal cell carcinoma
Huang, Yi1,2; Gao, Shengjie3; Wu, Song1,2,4; Song, Pengfei3; Sun, Xiaojuan1,2; Hu, Xueda3; Zhang, Shiqiang5; Yu, Yuan3; Zhu, Jialou3; Li, Cailing5; Qin, Zike4; Xie, Liangfu5; Yao, Qiong3; Tang, Aifa1,2; Li, Zesong1,2; Guo, Guangwu3; Wan, Shengqing3; Dong, Pei4; Sun, Liang1; Li, Weiping1; Wang, Daping1; Gui, Yaoting5; Yang, Huanming3; Zhou, Fangjian4; Zhang, Xiuqing3; Cai, Zhiming1,2
关键词Renal Cancer Tumor Evolution Metastasis
刊名INTERNATIONAL JOURNAL OF CANCER
2014-07-01
DOI10.1002/ijc.28654
135期:1页:78-87
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]PROSTATE-CANCER ; GENE ; EVOLUTION ; TUMORS ; P85-ALPHA ; MUTATION ; OVARIAN ; GENOME
英文摘要

Primary renal cell carcinomas (pRCCs) have a high degree of intratumoral heterogeneity and are composed of multiple distinct subclones. However, it remains largely unknown that whether metastatic renal cell carcinomas (mRCCs) also have startling intratumoral heterogeneity or whether development of mRCCs is due to early dissemination or late diagnosis. To decipher the evolution of mRCC, we analyzed the multilayered molecular profiles of pRCC, local invasion of the vena cava (IVC), and distant metastasis to the brain (MB) from the same patient using whole-genome sequencing, whole-exome sequencing, DNA methylome profiling, and transcriptome sequencing. We found that mRCC had a lower degree of heterogeneity than pRCC and was likely to result from recent clonal expansion of a rare, advantageous subclone. Consequently, some key pathways that are targeted by clinically available drugs showed distinct expression patterns between pRCC and mRCC. From the genetic distances between different tumor subclones, we estimated that the progeny subclone giving rise to distant metastasis took over half a decade to acquire the full potential of metastasis since the birth of the subclone that evolved into IVC. Our evidence supported that mRCC was monoclonal and distant metastasis occurred late during renal cancer progression. Thus, there was a broad window for early detection of circulating tumor cells and future targeted treatments for patients with mRCCs should rely on the molecular profiles of metastases.

语种英语
WOS记录号WOS:000334353500009
项目编号81272840 ; 81201579 ; 81301740 ; 81071704 ; JCYJ20130401114928183 ; JCYJ20130401114715714
资助机构National Natural Science Foundation of China ; Young Scientists Fund of the National Natural Science Foundation of China ; Shenzhen Basic Research Project ; Shenzhen Knowledge Innovation Project
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52056
专题北京大学深圳医院
作者单位1.BGI Shenzhen, Shenzhen, Peoples R China
2.Shenzhen Univ, Affiliated Hosp 1, Shenzhen Peoples Hosp 2, Shenzhen 518035, Peoples R China
3.Shenzhen Key Lab Genitourinary Tumor, Natl Reg Key Technol Engn Lab Clin Applicat Canc, Shenzhen, Peoples R China
4.Sun Yat Sen Univ, Ctr Canc, Dept Urol, Guangzhou 510275, Guangdong, Peoples R China
5.Peking Univ, Shenzhen Hosp, Shenzhen PKU HKUST Med Ctr,Inst Pathol, Guangdong & Shenzhen Key Lab Male Reprod Med & Ge, Shenzhen, Peoples R China
推荐引用方式
GB/T 7714
Huang, Yi,Gao, Shengjie,Wu, Song,et al. Multilayered molecular profiling supported the monoclonal origin of metastatic renal cell carcinoma[J]. INTERNATIONAL JOURNAL OF CANCER,2014,135(1):78-87.
APA Huang, Yi.,Gao, Shengjie.,Wu, Song.,Song, Pengfei.,Sun, Xiaojuan.,...&Cai, Zhiming.(2014).Multilayered molecular profiling supported the monoclonal origin of metastatic renal cell carcinoma.INTERNATIONAL JOURNAL OF CANCER,135(1),78-87.
MLA Huang, Yi,et al."Multilayered molecular profiling supported the monoclonal origin of metastatic renal cell carcinoma".INTERNATIONAL JOURNAL OF CANCER 135.1(2014):78-87.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Huang, Yi]的文章
[Gao, Shengjie]的文章
[Wu, Song]的文章
百度学术
百度学术中相似的文章
[Huang, Yi]的文章
[Gao, Shengjie]的文章
[Wu, Song]的文章
必应学术
必应学术中相似的文章
[Huang, Yi]的文章
[Gao, Shengjie]的文章
[Wu, Song]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。