IR@PKUHSC  > 北京大学基础医学院  > 神经生物学系
学科主题基础医学
Triptolide inhibits TNF-alpha, IL-I beta and NO production in primary microglial cultures
Zhou, HF; Niu, DB; Xue, B; Li, FQ; Liu, XY; He, QH; Wang, XH; Wang, XM
关键词inflammation microglia neuroprotection nitric oxide proinflammatory cytokines triptolide Tripterygium wilfordii Hook F.
刊名NEUROREPORT
2003-05-23
DOI10.1097/01.wnr.0000073682.00308.47
14期:7页:1091-1095
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]TUMOR-NECROSIS-FACTOR ; NITRIC-OXIDE SYNTHASE ; WILFORDII HOOK F ; INTRANIGRAL INJECTION ; DOPAMINERGIC SYSTEM ; CELLS ; TRIPTERYGIUM ; ACTIVATION ; NEURODEGENERATION ; EXPRESSION
英文摘要

Microglia are believed to participate in the mediation of neurodegeneration through producing a variety of cytotoxic factors upon activation. Pharmacological intervention in microglial activation may therefore exert a neuroprotective effect. In exploring pharmacological agents that can affect microglial activation, we found in this study that triptolide possesses a powerful inhibitory influence over microglia. Pretreatment with triptolide was able to dose-dependently reduce the lipopolysaccharide (LPS)-induced nitrite accumulation and tumor necrosis factor-alpha and interleukin-1beta release from LPS-activated microglia as revealed by Griess reaction and ELISA, respectively. Triptolide reduced LPS-stimulated mRNA expression of all three inflammatory factors. The results obtained from this study demonstrate that triptolide can inhibit inflammatory responses of microglia to inflammatory stimulation via a mechanism involving the inhibition of the synthesis and release of inflammatory factors.

语种英语
WOS记录号WOS:000184057700037
Citation statistics
Cited Times:56[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52061
Collection北京大学基础医学院_神经生物学系
作者单位Peking Univ, Neurosci Res Inst, Beijing 100083, Peoples R China
Recommended Citation
GB/T 7714
Zhou, HF,Niu, DB,Xue, B,et al. Triptolide inhibits TNF-alpha, IL-I beta and NO production in primary microglial cultures[J]. NEUROREPORT,2003,14(7):1091-1095.
APA Zhou, HF.,Niu, DB.,Xue, B.,Li, FQ.,Liu, XY.,...&Wang, XM.(2003).Triptolide inhibits TNF-alpha, IL-I beta and NO production in primary microglial cultures.NEUROREPORT,14(7),1091-1095.
MLA Zhou, HF,et al."Triptolide inhibits TNF-alpha, IL-I beta and NO production in primary microglial cultures".NEUROREPORT 14.7(2003):1091-1095.
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