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学科主题: 基础医学
题名:
Triptolide inhibits TNF-alpha, IL-I beta and NO production in primary microglial cultures
作者: Zhou, HF; Niu, DB; Xue, B; Li, FQ; Liu, XY; He, QH; Wang, XH; Wang, XM
关键词: inflammation ; microglia ; neuroprotection ; nitric oxide ; proinflammatory cytokines ; triptolide ; Tripterygium wilfordii Hook F.
刊名: NEUROREPORT
发表日期: 2003-05-23
DOI: 10.1097/01.wnr.0000073682.00308.47
卷: 14, 期:7, 页:1091-1095
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: TUMOR-NECROSIS-FACTOR ; NITRIC-OXIDE SYNTHASE ; WILFORDII HOOK F ; INTRANIGRAL INJECTION ; DOPAMINERGIC SYSTEM ; CELLS ; TRIPTERYGIUM ; ACTIVATION ; NEURODEGENERATION ; EXPRESSION
英文摘要:

Microglia are believed to participate in the mediation of neurodegeneration through producing a variety of cytotoxic factors upon activation. Pharmacological intervention in microglial activation may therefore exert a neuroprotective effect. In exploring pharmacological agents that can affect microglial activation, we found in this study that triptolide possesses a powerful inhibitory influence over microglia. Pretreatment with triptolide was able to dose-dependently reduce the lipopolysaccharide (LPS)-induced nitrite accumulation and tumor necrosis factor-alpha and interleukin-1beta release from LPS-activated microglia as revealed by Griess reaction and ELISA, respectively. Triptolide reduced LPS-stimulated mRNA expression of all three inflammatory factors. The results obtained from this study demonstrate that triptolide can inhibit inflammatory responses of microglia to inflammatory stimulation via a mechanism involving the inhibition of the synthesis and release of inflammatory factors.

语种: 英语
WOS记录号: WOS:000184057700037
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52061
Appears in Collections:基础医学院_神经生物学系_期刊论文

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作者单位: Peking Univ, Neurosci Res Inst, Beijing 100083, Peoples R China

Recommended Citation:
Zhou, HF,Niu, DB,Xue, B,et al. Triptolide inhibits TNF-alpha, IL-I beta and NO production in primary microglial cultures[J]. NEUROREPORT,2003,14(7):1091-1095.
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