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学科主题: 临床医学
题名:
Limitations in SELDI-TOF MS whole serum proteomic profiling with IMAC surface to specifically detect colorectal cancer
作者: Wang, Qi1,6; Shen, Jing2; Li, Zhen-fu2; Jie, Jian-zheng3; Wang, Wen-yue3; Wang, Jin4; Zhang, Zhong-tao4; Li, Zhi-xia5; Yan, Li1; Gu, Jin1
刊名: BMC CANCER
发表日期: 2009-08-19
DOI: 10.1186/1471-2407-9-287
卷: 9
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: PROSTATE-CANCER ; MASS-SPECTROMETRY ; HEPATOCELLULAR-CARCINOMA ; CELL CARCINOMA ; OVARIAN-CANCER ; COLON-CANCER ; STOOL DNA ; PATTERN ; IDENTIFICATION ; BIOMARKERS
英文摘要:

Background: Surface enhanced laser desorption and ionization time-of-flight mass spectrometry (SELDI-TOF-MS) analysis on serum samples was reported to be able to detect colorectal cancer (CRC) from normal or control patients. We carried out a validation study of a SELDI-TOF MS approach with IMAC surface sample processing to identify CRC.

Methods: A retrospective cohort of 338 serum samples including 154 CRCs, 67 control cancers and 117 non-cancerous conditions was profiled using SELDI-TOF-MS.

Results: No CRC "specific" classifier was found. However, a classifier consisting of two protein peaks separates cancer from non-cancerous conditions with high accuracy.

Conclusion: In this study, the SELDI-TOF-MS-based protein expression profiling approach did not perform to identify CRC. However, this technique is promising in distinguishing patients with cancer from a non-cancerous population; it may be useful for monitoring recurrence of CRC after treatment.

语种: 英语
所属项目编号: 2005-1019
项目资助者: Capital Development of Medical Research Fund
WOS记录号: WOS:000270307400001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52062
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: 1.Peking Univ, Key Lab Carcinogenesis & Translat Res, Minist Educ,Beijing Canc Hosp & Inst, Dept Colorectal Surg,Sch Oncol, Beijing 100871, Peoples R China
2.Peking Univ, Cent Lab Biochem & Mol Biol, Sch Oncol, Beijing Canc Hosp & Inst, Beijing 100871, Peoples R China
3.China Japan Friendship Hosp, Dept Gen Surg, Beijing, Peoples R China
4.Beijing Friendship Hosp, Dept Gen Surg, Beijing, Peoples R China
5.Beijing Tongren Hosp, Dept Gen Surg, Beijing, Peoples R China
6.Huazhong Univ Sci & Technol, Hepat Surg Ctr, Tongji Hosp, Tongji Med Coll, Wuhan 430074, Peoples R China

Recommended Citation:
Wang, Qi,Shen, Jing,Li, Zhen-fu,et al. Limitations in SELDI-TOF MS whole serum proteomic profiling with IMAC surface to specifically detect colorectal cancer[J]. BMC CANCER,2009,9.
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