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学科主题临床医学
Limitations in SELDI-TOF MS whole serum proteomic profiling with IMAC surface to specifically detect colorectal cancer
Wang, Qi1,6; Shen, Jing2; Li, Zhen-fu2; Jie, Jian-zheng3; Wang, Wen-yue3; Wang, Jin4; Zhang, Zhong-tao4; Li, Zhi-xia5; Yan, Li1; Gu, Jin1
刊名BMC CANCER
2009-08-19
DOI10.1186/1471-2407-9-287
9
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]PROSTATE-CANCER ; MASS-SPECTROMETRY ; HEPATOCELLULAR-CARCINOMA ; CELL CARCINOMA ; OVARIAN-CANCER ; COLON-CANCER ; STOOL DNA ; PATTERN ; IDENTIFICATION ; BIOMARKERS
英文摘要

Background: Surface enhanced laser desorption and ionization time-of-flight mass spectrometry (SELDI-TOF-MS) analysis on serum samples was reported to be able to detect colorectal cancer (CRC) from normal or control patients. We carried out a validation study of a SELDI-TOF MS approach with IMAC surface sample processing to identify CRC.

Methods: A retrospective cohort of 338 serum samples including 154 CRCs, 67 control cancers and 117 non-cancerous conditions was profiled using SELDI-TOF-MS.

Results: No CRC "specific" classifier was found. However, a classifier consisting of two protein peaks separates cancer from non-cancerous conditions with high accuracy.

Conclusion: In this study, the SELDI-TOF-MS-based protein expression profiling approach did not perform to identify CRC. However, this technique is promising in distinguishing patients with cancer from a non-cancerous population; it may be useful for monitoring recurrence of CRC after treatment.

语种英语
WOS记录号WOS:000270307400001
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52062
专题北京大学临床肿瘤学院
北京大学临床肿瘤学院_中心实验室
北京大学临床肿瘤学院_结直肠肿瘤外科
作者单位1.Peking Univ, Key Lab Carcinogenesis & Translat Res, Minist Educ,Beijing Canc Hosp & Inst, Dept Colorectal Surg,Sch Oncol, Beijing 100871, Peoples R China
2.Peking Univ, Cent Lab Biochem & Mol Biol, Sch Oncol, Beijing Canc Hosp & Inst, Beijing 100871, Peoples R China
3.China Japan Friendship Hosp, Dept Gen Surg, Beijing, Peoples R China
4.Beijing Friendship Hosp, Dept Gen Surg, Beijing, Peoples R China
5.Beijing Tongren Hosp, Dept Gen Surg, Beijing, Peoples R China
6.Huazhong Univ Sci & Technol, Hepat Surg Ctr, Tongji Hosp, Tongji Med Coll, Wuhan 430074, Peoples R China
推荐引用方式
GB/T 7714
Wang, Qi,Shen, Jing,Li, Zhen-fu,et al. Limitations in SELDI-TOF MS whole serum proteomic profiling with IMAC surface to specifically detect colorectal cancer[J]. BMC CANCER,2009,9.
APA Wang, Qi.,Shen, Jing.,Li, Zhen-fu.,Jie, Jian-zheng.,Wang, Wen-yue.,...&Gu, Jin.(2009).Limitations in SELDI-TOF MS whole serum proteomic profiling with IMAC surface to specifically detect colorectal cancer.BMC CANCER,9.
MLA Wang, Qi,et al."Limitations in SELDI-TOF MS whole serum proteomic profiling with IMAC surface to specifically detect colorectal cancer".BMC CANCER 9(2009).
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