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Efficacy and reliability of long-term implantation of multi-channel microelectrode arrays in the optical nerve sheath of rabbit eyes
Wang, Kai1,2; Li, Xiao-Qian3; Li, Xiao-Xin1,2; Pei, Wei-Hua3; Chen, Hong-Da3; Dong, Jian-Qiang4
关键词Animal Testing Visual Prosthesis Microelectrode Optic Nerve Evoked Potentials
刊名VISION RESEARCH
2011-09-01
DOI10.1016/j.visres.2011.06.019
51期:17页:1897-1906
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences ; Ophthalmology
研究领域[WOS]Neurosciences & Neurology ; Ophthalmology
关键词[WOS]ELECTRICAL-STIMULATION ; RETINITIS-PIGMENTOSA ; EVOKED-POTENTIALS ; ARTIFICIAL VISION ; VISUAL-CORTEX ; INNER RETINA ; PROSTHESIS ; ELECTRODE ; CELL ; ABNORMALITIES
英文摘要

In addition to epiretinal and subretinal areas, the optic nerve (ON) is also a candidate location for implanting visual prosthesis to restore vision of patients with retinitis pigmentosa (RP). Since the ON receives all the signals from the retina, stimulating the ON may potentially evoke phosphenes over a wider range of visual field. In this study, we designed a 9-channel microelectrode array and implanted it between the dura mater and pia mater of rabbit ONs by lateral orbitotomy. We recorded the current thresholds and evaluated the efficacy of the array using electrically evoked potentials (EEPs). Spatial discrimination of approximately 20 was verified by EEP maps over visual cortex. A large area of the visual field (over 130 along horizontal meridian) could be activated by this microelectrode array. Visual evoked potentials (VEPs) and different pathological examinations were used to examine potential damage of ONs. One year post implantation, we did not notice significant damages to either the ONs or the microelectrode arrays. EEPs were successfully recorded up to 6 months post implantations. However, further studies are still needed to reduce fibrous encapsulation of the microelectrode array, which resulted in a gradual elevation of current thresholds to elicit EEPs. (C) 2011 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000294833000002
项目编号2005CB724307 ; 2011CB510200 ; 2009AA04Z326
资助机构National Basic Research Program of China ; Chinese High-Tech Research and Development (863) Program
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52064
专题北京大学第二临床医学院_眼科
作者单位1.Minist Educ, Lab Vis Loss & Restorat, Beijing 100034, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Ophthalmol, Beijing 100044, Peoples R China
3.Chinese Acad Sci, Inst Semicond, Beijing 100083, Peoples R China
4.Peking Univ, Peoples Hosp, Dept Pathol, Cent Lab, Beijing 100044, Peoples R China
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GB/T 7714
Wang, Kai,Li, Xiao-Qian,Li, Xiao-Xin,et al. Efficacy and reliability of long-term implantation of multi-channel microelectrode arrays in the optical nerve sheath of rabbit eyes[J]. VISION RESEARCH,2011,51(17):1897-1906.
APA Wang, Kai,Li, Xiao-Qian,Li, Xiao-Xin,Pei, Wei-Hua,Chen, Hong-Da,&Dong, Jian-Qiang.(2011).Efficacy and reliability of long-term implantation of multi-channel microelectrode arrays in the optical nerve sheath of rabbit eyes.VISION RESEARCH,51(17),1897-1906.
MLA Wang, Kai,et al."Efficacy and reliability of long-term implantation of multi-channel microelectrode arrays in the optical nerve sheath of rabbit eyes".VISION RESEARCH 51.17(2011):1897-1906.
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