北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第二临床医学院  > 眼科  > 期刊论文
学科主题: 临床医学
题名:
Efficacy and reliability of long-term implantation of multi-channel microelectrode arrays in the optical nerve sheath of rabbit eyes
作者: Wang, Kai1,2; Li, Xiao-Qian3; Li, Xiao-Xin1,2; Pei, Wei-Hua3; Chen, Hong-Da3; Dong, Jian-Qiang4
关键词: Animal testing ; Visual prosthesis ; Microelectrode ; Optic nerve ; Evoked potentials
刊名: VISION RESEARCH
发表日期: 2011-09-01
DOI: 10.1016/j.visres.2011.06.019
卷: 51, 期:17, 页:1897-1906
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences ; Ophthalmology
研究领域[WOS]: Neurosciences & Neurology ; Ophthalmology
关键词[WOS]: ELECTRICAL-STIMULATION ; RETINITIS-PIGMENTOSA ; EVOKED-POTENTIALS ; ARTIFICIAL VISION ; VISUAL-CORTEX ; INNER RETINA ; PROSTHESIS ; ELECTRODE ; CELL ; ABNORMALITIES
英文摘要:

In addition to epiretinal and subretinal areas, the optic nerve (ON) is also a candidate location for implanting visual prosthesis to restore vision of patients with retinitis pigmentosa (RP). Since the ON receives all the signals from the retina, stimulating the ON may potentially evoke phosphenes over a wider range of visual field. In this study, we designed a 9-channel microelectrode array and implanted it between the dura mater and pia mater of rabbit ONs by lateral orbitotomy. We recorded the current thresholds and evaluated the efficacy of the array using electrically evoked potentials (EEPs). Spatial discrimination of approximately 20 was verified by EEP maps over visual cortex. A large area of the visual field (over 130 along horizontal meridian) could be activated by this microelectrode array. Visual evoked potentials (VEPs) and different pathological examinations were used to examine potential damage of ONs. One year post implantation, we did not notice significant damages to either the ONs or the microelectrode arrays. EEPs were successfully recorded up to 6 months post implantations. However, further studies are still needed to reduce fibrous encapsulation of the microelectrode array, which resulted in a gradual elevation of current thresholds to elicit EEPs. (C) 2011 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 2005CB724307 ; 2011CB510200 ; 2009AA04Z326
项目资助者: National Basic Research Program of China ; Chinese High-Tech Research and Development (863) Program
WOS记录号: WOS:000294833000002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52064
Appears in Collections:北京大学第二临床医学院_眼科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Minist Educ, Lab Vis Loss & Restorat, Beijing 100034, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Ophthalmol, Beijing 100044, Peoples R China
3.Chinese Acad Sci, Inst Semicond, Beijing 100083, Peoples R China
4.Peking Univ, Peoples Hosp, Dept Pathol, Cent Lab, Beijing 100044, Peoples R China

Recommended Citation:
Wang, Kai,Li, Xiao-Qian,Li, Xiao-Xin,et al. Efficacy and reliability of long-term implantation of multi-channel microelectrode arrays in the optical nerve sheath of rabbit eyes[J]. VISION RESEARCH,2011,51(17):1897-1906.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Wang, Kai]'s Articles
[Li, Xiao-Qian]'s Articles
[Li, Xiao-Xin]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Wang, Kai]‘s Articles
[Li, Xiao-Qian]‘s Articles
[Li, Xiao-Xin]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace