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学科主题: 临床医学
题名:
Autoantibody production from a thymoma and a follicular dendritic cell sarcoma associated with paraneoplastic pemphigus
作者: Wang, J1; Bu, DF1; Li, T1; Zheng, R1; Zhang, BX1; Chen, XX1; Zhu, XJ1
关键词: autoantibody ; follicular dendritic cell sarcoma ; paraneoplastic pemphigus ; thymoma
刊名: BRITISH JOURNAL OF DERMATOLOGY
发表日期: 2005-09-01
DOI: 10.1111/j.1365-2133.2005.06599.x
卷: 153, 期:3, 页:558-564
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Dermatology
研究领域[WOS]: Dermatology
关键词[WOS]: INDIRECT IMMUNOFLUORESCENCE ; CASTLEMANS-DISEASE ; PERIPLAKIN ; ENVOPLAKIN ; ANTIBODIES ; NEOPLASIA ; ANTIGENS ; PROTEINS ; FAMILY ; TUMORS
英文摘要:

Background Paraneoplastic pemphigus (PNP) is an autoimmune mucocutaneous disease. We previously reported that B cells in a Castleman tumour associated with PNP produced autoantibodies. However, it is uncertain whether the production of autoantibodies from the associated tumour is a common mechanism in PNP.

Objectives To investigate autoantibody production in a thymoma and a follicular dendritic cell sarcoma that were excised from two patients with PNP.

Mehods Tumour cells were cultured, and their surface markers were identified. Indirect immunofluorescence, immunoblotting and enzyme-linked immunosorbent assay (ELISA) using culture media from the tumours were used to detect PNP autoantibodies.

Results B cells with markers (CD22+, surface membrane IgG+ and surface membrane IgM+) of mature B lymphocytes constituted a proportion of cultured tumour cells in both tumours. Western blot showed that the medium from both the thymoma and the follicular dendritic cell sarcoma cells recognized 190-kDa periplakin and 210-kDa envoplakin bands of human epithelial proteins as well as recombinant linker regions of periplakin, envoplakin, desmoplakin and bullous pemphigoid antigen 1. ELISA was positive for antidesmoglein 3 antibody.

Conclusion The presence and localization in tumours of B-lymphocyte clones against proteins of the plakin family and desmoglein 3 in skin may not be confined to PNP with Castleman disease, but is possibly a common mechanism in PNP associated with various tumours.

语种: 英语
WOS记录号: WOS:000231400300014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52067
Appears in Collections:北京大学第一临床医学院_皮肤性病科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Dept Dermatol, Beijing 100034, Peoples R China
2.Peking Univ, Hosp 1, Dept Pathol, Beijing 100034, Peoples R China

Recommended Citation:
Wang, J,Bu, DF,Li, T,et al. Autoantibody production from a thymoma and a follicular dendritic cell sarcoma associated with paraneoplastic pemphigus[J]. BRITISH JOURNAL OF DERMATOLOGY,2005,153(3):558-564.
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