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Autoantibody production from a thymoma and a follicular dendritic cell sarcoma associated with paraneoplastic pemphigus
Wang, J1; Bu, DF1; Li, T1; Zheng, R1; Zhang, BX1; Chen, XX1; Zhu, XJ1
关键词Autoantibody Follicular Dendritic Cell Sarcoma Paraneoplastic Pemphigus Thymoma
刊名BRITISH JOURNAL OF DERMATOLOGY
2005-09-01
DOI10.1111/j.1365-2133.2005.06599.x
153期:3页:558-564
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Dermatology
研究领域[WOS]Dermatology
关键词[WOS]INDIRECT IMMUNOFLUORESCENCE ; CASTLEMANS-DISEASE ; PERIPLAKIN ; ENVOPLAKIN ; ANTIBODIES ; NEOPLASIA ; ANTIGENS ; PROTEINS ; FAMILY ; TUMORS
英文摘要

Background Paraneoplastic pemphigus (PNP) is an autoimmune mucocutaneous disease. We previously reported that B cells in a Castleman tumour associated with PNP produced autoantibodies. However, it is uncertain whether the production of autoantibodies from the associated tumour is a common mechanism in PNP.

Objectives To investigate autoantibody production in a thymoma and a follicular dendritic cell sarcoma that were excised from two patients with PNP.

Mehods Tumour cells were cultured, and their surface markers were identified. Indirect immunofluorescence, immunoblotting and enzyme-linked immunosorbent assay (ELISA) using culture media from the tumours were used to detect PNP autoantibodies.

Results B cells with markers (CD22+, surface membrane IgG+ and surface membrane IgM+) of mature B lymphocytes constituted a proportion of cultured tumour cells in both tumours. Western blot showed that the medium from both the thymoma and the follicular dendritic cell sarcoma cells recognized 190-kDa periplakin and 210-kDa envoplakin bands of human epithelial proteins as well as recombinant linker regions of periplakin, envoplakin, desmoplakin and bullous pemphigoid antigen 1. ELISA was positive for antidesmoglein 3 antibody.

Conclusion The presence and localization in tumours of B-lymphocyte clones against proteins of the plakin family and desmoglein 3 in skin may not be confined to PNP with Castleman disease, but is possibly a common mechanism in PNP associated with various tumours.

语种英语
WOS记录号WOS:000231400300014
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被引频次:41[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52067
专题北京大学第一临床医学院_皮肤性病科
北京大学公共卫生学院_公共卫生学院
作者单位1.Peking Univ, Hosp 1, Dept Dermatol, Beijing 100034, Peoples R China
2.Peking Univ, Hosp 1, Dept Pathol, Beijing 100034, Peoples R China
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GB/T 7714
Wang, J,Bu, DF,Li, T,et al. Autoantibody production from a thymoma and a follicular dendritic cell sarcoma associated with paraneoplastic pemphigus[J]. BRITISH JOURNAL OF DERMATOLOGY,2005,153(3):558-564.
APA Wang, J.,Bu, DF.,Li, T.,Zheng, R.,Zhang, BX.,...&Zhu, XJ.(2005).Autoantibody production from a thymoma and a follicular dendritic cell sarcoma associated with paraneoplastic pemphigus.BRITISH JOURNAL OF DERMATOLOGY,153(3),558-564.
MLA Wang, J,et al."Autoantibody production from a thymoma and a follicular dendritic cell sarcoma associated with paraneoplastic pemphigus".BRITISH JOURNAL OF DERMATOLOGY 153.3(2005):558-564.
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