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Relationship between MTNR1B (melatonin receptor 1B gene) polymorphism rs10830963 and glucose levels in overweight children and adolescents
Reinehr, Thomas1; Scherag, Andre2; Wang, Hai-Jun3,4; Roth, Christian L.5; Kleber, Michaela1; Scherag, Susann4; Boes, Tanja2; Vogel, Carla2; Hebebrand, Johannes4; Hinney, Anke4
关键词Children Glucose Insulin Resistance Insulin Sensitivity Lifestyle Intervention Mtnr1b Overweight
刊名PEDIATRIC DIABETES
2011-06-01
DOI10.1111/j.1399-5448.2010.00738.x
12期:4页:435-441
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Endocrinology & Metabolism ; Pediatrics
研究领域[WOS]Endocrinology & Metabolism ; Pediatrics
关键词[WOS]LIFE-STYLE INTERVENTION ; FASTING PLASMA-GLUCOSE ; TYPE-2 DIABETES RISK ; BETA-CELL FUNCTION ; BODY-MASS INDEX ; OBESE CHILDREN ; INSULIN-RESISTANCE ; COMMON VARIANT ; FOLLOW-UP ; SENSITIVITY
英文摘要

Methods: We genotyped rs10830963 in 1118 overweight children and adolescents [mean age 10.7 yr, mean body mass index (BMI) 27.8 kg/m2]; 340 of these individuals completed a 1-yr lifestyle intervention (mean age 10.7 yr, mean BMI 27.9 kg/m2). The degree of overweight [BMI-SDS (standard deviation score)], fasting insulin, glucose, homeostasis model assessment for insulin resistance (HOMA-IR), and quantitative insulin sensitivity check index (QUICKI) were measured before and after intervention.

Results: We showed a significant relationship between rs10830963 and basal glucose levels [beta:1.101, 95% confidence interval (CI) 0.316-1.886 mg/dL per risk allele; p = 0.006] by linear regression adjusted for age, age2, and sex. There was no effect of the allele on insulin or indices of insulin resistance or sensitivity. After the 1-yr lifestyle intervention, we observed a significant reduction of BMI-SDS as well as an improvement of HOMA-IR and QUICKI, but no evidence for an association between rs10830963 genotype and changes of glucose levels.

Conclusions: The G-allele of rs10830693 in the MTNR1B gene was significantly related to glucose levels, while an impact of this genetic variant on the changes in glucose metabolism in children participating in a lifestyle intervention was not observable.

语种英语
WOS记录号WOS:000290964000011
项目编号01KU0903 ; 01GS0820 ; 01GI0839 ; 01GI0823
资助机构German Ministry of Education and Research (Bundesministerium fur Bildung und Forschung) ; German Ministry of Education and Research (National Genome Research Network, NGFNplus) ; German Ministry of Education and Research (Obesity Network LARGE/PREVENT) ; University of Witten/Herdecke
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被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52074
专题北京大学公共卫生学院
北京大学公共卫生学院_公共卫生学院
作者单位1.Univ Witten Herdecke, Dept Pediat Endocrinol Diabet & Nutr Med, Vest Hosp Children & Adolescents, D-45711 Datteln, Germany
2.Univ Duisburg Essen, Inst Med Informat Biometry & Epidemiol, Essen, Germany
3.Peking Univ, Div Maternal & Child Hlth, Sch Publ Hlth, Hlth Sci Ctr, Beijing 100871, Peoples R China
4.Univ Duisburg Essen, Dept Child & Adolescent Psychiat, Essen, Germany
5.Univ Washington, Seattle Childrens Hosp, Res Inst, Seattle, WA 98195 USA
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GB/T 7714
Reinehr, Thomas,Scherag, Andre,Wang, Hai-Jun,et al. Relationship between MTNR1B (melatonin receptor 1B gene) polymorphism rs10830963 and glucose levels in overweight children and adolescents[J]. PEDIATRIC DIABETES,2011,12(4):435-441.
APA Reinehr, Thomas.,Scherag, Andre.,Wang, Hai-Jun.,Roth, Christian L..,Kleber, Michaela.,...&Hinney, Anke.(2011).Relationship between MTNR1B (melatonin receptor 1B gene) polymorphism rs10830963 and glucose levels in overweight children and adolescents.PEDIATRIC DIABETES,12(4),435-441.
MLA Reinehr, Thomas,et al."Relationship between MTNR1B (melatonin receptor 1B gene) polymorphism rs10830963 and glucose levels in overweight children and adolescents".PEDIATRIC DIABETES 12.4(2011):435-441.
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