北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第二临床医学院  > 眼科  > 期刊论文
学科主题: 临床医学
题名:
Is Asthma Related to Choroidal Neovascularization?
作者: Sun, Yaoyao1,2; Yu, Wenzhen1,2; Huang, Lvzhen1,2; Hou, Jing1,2; Gong, Peihua3; Zheng, Yi4; Zhao, Mingwei1,2; Zhou, Peng1,2,5; Li, Xiaoxin1,2
刊名: PLOS ONE
发表日期: 2012-05-02
DOI: 10.1371/journal.pone.0035415
卷: 7, 期:5
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: AGE-RELATED MACULOPATHY ; BEAVER DAM EYE ; MACULAR DEGENERATION ; VISUAL IMPAIRMENT ; MOUSE MODEL ; COMPLEMENT ; C3 ; PROGRESSION ; PREVALENCE ; COMPSTATIN
英文摘要:

Background: Age-related degeneration(AMD) and asthma are both diseases that are related to the activation of the complement system. The association between AMD and asthma has been debated in previous studies. The authors investigated the relationship between AMD and asthma systemically.

Principal Findings: The epidemiological study showed that asthma was related to choroidal neovascularization(CNV) subtype(OR = 1.721, P = 0.023). However, the meta-analysis showed there was no association between AMD and asthma. In an animal model, we found more fluoresce in leakage of CNV lesions by FA analysis and more angiogenesis by histological analysis in rats with asthma. Western blot demonstrated an elevated level of C3 alpha-chain, C3 alpha′-chain and VEGF. After compstatin was intravitreally injected, CNV leakage decreased according to FA analysis, with the level of C3 and VEGF protein decreasing at the same time.

Significance: This study first investigated the relationship between AMD and asthma systematically, and it was found that asthma could be a risk factor for the development of AMD. The study may provide a better understanding of the disease, which may advance the potential for screening asthma patients in clinical practice.

语种: 英语
所属项目编号: 2011CB510200 ; 81070740
项目资助者: National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China
WOS记录号: WOS:000305341500021
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52077
Appears in Collections:北京大学第二临床医学院_眼科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Minist Educ, Key Lab Vis Loss & Restorat, Beijing, Peoples R China
2.Peking Univ Peoples Hosp, Dept Ophthalmol, Beijing, Peoples R China
3.Peking Univ Peoples Hosp, Dept Respirat, Beijing, Peoples R China
4.Peking Univ, Dept Immunol, Sch Basic Med Sci, Beijing 100871, Peoples R China
5.Fudan Univ, Dept Ophthalmol Eye & ENT, Hosp Affiliated, Shanghai 200433, Peoples R China

Recommended Citation:
Sun, Yaoyao,Yu, Wenzhen,Huang, Lvzhen,et al. Is Asthma Related to Choroidal Neovascularization?[J]. PLOS ONE,2012,7(5).
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Sun, Yaoyao]'s Articles
[Yu, Wenzhen]'s Articles
[Huang, Lvzhen]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Sun, Yaoyao]‘s Articles
[Yu, Wenzhen]‘s Articles
[Huang, Lvzhen]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace