IR@PKUHSC  > 北京大学第二临床医学院  > 眼科
学科主题临床医学
Is Asthma Related to Choroidal Neovascularization?
Sun, Yaoyao1,2; Yu, Wenzhen1,2; Huang, Lvzhen1,2; Hou, Jing1,2; Gong, Peihua3; Zheng, Yi4; Zhao, Mingwei1,2; Zhou, Peng1,2,5; Li, Xiaoxin1,2
刊名PLOS ONE
2012-05-02
DOI10.1371/journal.pone.0035415
7期:5
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
资助者National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China ; National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]AGE-RELATED MACULOPATHY ; BEAVER DAM EYE ; MACULAR DEGENERATION ; VISUAL IMPAIRMENT ; MOUSE MODEL ; COMPLEMENT ; C3 ; PROGRESSION ; PREVALENCE ; COMPSTATIN
英文摘要

Background: Age-related degeneration(AMD) and asthma are both diseases that are related to the activation of the complement system. The association between AMD and asthma has been debated in previous studies. The authors investigated the relationship between AMD and asthma systemically.

Principal Findings: The epidemiological study showed that asthma was related to choroidal neovascularization(CNV) subtype(OR = 1.721, P = 0.023). However, the meta-analysis showed there was no association between AMD and asthma. In an animal model, we found more fluoresce in leakage of CNV lesions by FA analysis and more angiogenesis by histological analysis in rats with asthma. Western blot demonstrated an elevated level of C3 alpha-chain, C3 alpha′-chain and VEGF. After compstatin was intravitreally injected, CNV leakage decreased according to FA analysis, with the level of C3 and VEGF protein decreasing at the same time.

Significance: This study first investigated the relationship between AMD and asthma systematically, and it was found that asthma could be a risk factor for the development of AMD. The study may provide a better understanding of the disease, which may advance the potential for screening asthma patients in clinical practice.

语种英语
所属项目编号2011CB510200 ; 81070740
资助者National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China ; National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China
WOS记录号WOS:000305341500021
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52077
专题北京大学第二临床医学院_眼科
作者单位1.Minist Educ, Key Lab Vis Loss & Restorat, Beijing, Peoples R China
2.Peking Univ Peoples Hosp, Dept Ophthalmol, Beijing, Peoples R China
3.Peking Univ Peoples Hosp, Dept Respirat, Beijing, Peoples R China
4.Peking Univ, Dept Immunol, Sch Basic Med Sci, Beijing 100871, Peoples R China
5.Fudan Univ, Dept Ophthalmol Eye & ENT, Hosp Affiliated, Shanghai 200433, Peoples R China
推荐引用方式
GB/T 7714
Sun, Yaoyao,Yu, Wenzhen,Huang, Lvzhen,et al. Is Asthma Related to Choroidal Neovascularization?[J]. PLOS ONE,2012,7(5).
APA Sun, Yaoyao.,Yu, Wenzhen.,Huang, Lvzhen.,Hou, Jing.,Gong, Peihua.,...&Li, Xiaoxin.(2012).Is Asthma Related to Choroidal Neovascularization?.PLOS ONE,7(5).
MLA Sun, Yaoyao,et al."Is Asthma Related to Choroidal Neovascularization?".PLOS ONE 7.5(2012).
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