|Is Asthma Related to Choroidal Neovascularization?|
|Sun, Yaoyao1,2; Yu, Wenzhen1,2; Huang, Lvzhen1,2; Hou, Jing1,2; Gong, Peihua3; Zheng, Yi4; Zhao, Mingwei1,2; Zhou, Peng1,2,5; Li, Xiaoxin1,2|
|WOS标题词||Science & Technology|
|研究领域[WOS]||Science & Technology - Other Topics|
|关键词[WOS]||AGE-RELATED MACULOPATHY ; BEAVER DAM EYE ; MACULAR DEGENERATION ; VISUAL IMPAIRMENT ; MOUSE MODEL ; COMPLEMENT ; C3 ; PROGRESSION ; PREVALENCE ; COMPSTATIN|
Background: Age-related degeneration(AMD) and asthma are both diseases that are related to the activation of the complement system. The association between AMD and asthma has been debated in previous studies. The authors investigated the relationship between AMD and asthma systemically.
Principal Findings: The epidemiological study showed that asthma was related to choroidal neovascularization(CNV) subtype(OR = 1.721, P = 0.023). However, the meta-analysis showed there was no association between AMD and asthma. In an animal model, we found more fluoresce in leakage of CNV lesions by FA analysis and more angiogenesis by histological analysis in rats with asthma. Western blot demonstrated an elevated level of C3 alpha-chain, C3 alpha′-chain and VEGF. After compstatin was intravitreally injected, CNV leakage decreased according to FA analysis, with the level of C3 and VEGF protein decreasing at the same time.
Significance: This study first investigated the relationship between AMD and asthma systematically, and it was found that asthma could be a risk factor for the development of AMD. The study may provide a better understanding of the disease, which may advance the potential for screening asthma patients in clinical practice.
|作者单位||1.Minist Educ, Key Lab Vis Loss & Restorat, Beijing, Peoples R China|
2.Peking Univ Peoples Hosp, Dept Ophthalmol, Beijing, Peoples R China
3.Peking Univ Peoples Hosp, Dept Respirat, Beijing, Peoples R China
4.Peking Univ, Dept Immunol, Sch Basic Med Sci, Beijing 100871, Peoples R China
5.Fudan Univ, Dept Ophthalmol Eye & ENT, Hosp Affiliated, Shanghai 200433, Peoples R China
|Sun, Yaoyao,Yu, Wenzhen,Huang, Lvzhen,et al. Is Asthma Related to Choroidal Neovascularization?[J]. PLOS ONE,2012,7(5).|
|APA||Sun, Yaoyao.,Yu, Wenzhen.,Huang, Lvzhen.,Hou, Jing.,Gong, Peihua.,...&Li, Xiaoxin.(2012).Is Asthma Related to Choroidal Neovascularization?.PLOS ONE,7(5).|
|MLA||Sun, Yaoyao,et al."Is Asthma Related to Choroidal Neovascularization?".PLOS ONE 7.5(2012).|