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THE ROLE OF MONITORING VANCOMYCIN LEVELS IN PATIENTS WITH PERITONEAL DIALYSIS-ASSOCIATED PERITONITIS
Stevenson, Sarah1; Tang, Wen1,2; Cho, Yeoungjee2; Mudge, David W.1; Hawley, Carmel M.1; Badve, Sunil V.1; Johnson, David W.1
关键词Kidney Failure Chronic Outcomes Peritoneal Dialysis Peritonitis Therapeutic Drug Monitoring Vancomycin
刊名PERITONEAL DIALYSIS INTERNATIONAL
2015-03-01
DOI10.3747/pdi.2013.00156
35期:2页:222-228
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Urology & Nephrology
资助者International Society of Peritoneal Dialysis Scholarship ; National Natural Science Foundation of China ; Beijing Municipal Science &amp ; Technology Commission ; Fund of Peking University Third Hospital ; Queensland Government Health Research Fellowship ; International Society of Peritoneal Dialysis Scholarship ; National Natural Science Foundation of China ; Beijing Municipal Science &amp ; Technology Commission ; Fund of Peking University Third Hospital ; Queensland Government Health Research Fellowship
研究领域[WOS]Urology & Nephrology
关键词[WOS]MULTICENTER REGISTRY ; ANTIBIOTIC LEVELS ; NEW-ZEALAND ; OUTCOMES ; MICROBIOLOGY ; INFECTIONS ; AUSTRALIA ; MORTALITY
英文摘要

Background: There is limited available evidence regarding the role of monitoring serum vancomycin concentrations during treatment of peritoneal dialysis (PD)-associated peritonitis.

Methods: A total of 150 PD patients experiencing 256 episodes of either gram-positive or culture-negative peritonitis were included to investigate the relationship between measured serum vancomycin within the first week and clinical outcomes of cure, relapse, repeat or recurrence of peritonitis, catheter removal, temporary or permanent transfer to hemodialysis, hospitalization and death.

Results: Vancomycin was used as an initial empiric antibiotic in 54 gram-positive or culture-negative peritonitis episodes among 34 patients. The median number of serum vancomycin level measurements in the first week was 3 (interquartile range; IQR 1 -4). The mean day-2 vancomycin level, measured in 34 (63%) episodes, was 17.5 +/- 5.2mg/L. Hospitalized patients were more likely to have serum vancomycin levels measured on day 2 and = 3 measurements in the first week. The peritonitis cure rates were similar between patients with <3 and >= 3 measurements in the first week (77% vs 57%, p = 0.12) and if day-2 vancomycin levels were measured or not (68% vs 65%, p = 0.84). The average day-2 (18.0 +/- 5.9 vs 16.6 +/- 3.2, p = 0.5), first-week average (18.6 +/- 5.1 vs 18.6 +/- 4.3, p = 0.9) and nadir (14.5 +/- 4.1 vs 13.6 +/- 4.2, p = 0.5) vancomycin levels were comparable in patients who did or did not achieve peritonitis cure. Similar results were observed for all other clinical outcomes.

Conclusion: The clinical outcomes of gram-positive and culture-negative peritonitis episodes are not associated with either the frequency or levels of serum vancomycin measurements in the first week of treatment when vancomycin is dosed according to International Society for Peritoneal Dialysis (ISPD) Guidelines.

语种英语
所属项目编号30900681 ; D09050704310905 ; 76496-02
资助者International Society of Peritoneal Dialysis Scholarship ; National Natural Science Foundation of China ; Beijing Municipal Science &amp ; Technology Commission ; Fund of Peking University Third Hospital ; Queensland Government Health Research Fellowship ; International Society of Peritoneal Dialysis Scholarship ; National Natural Science Foundation of China ; Beijing Municipal Science &amp ; Technology Commission ; Fund of Peking University Third Hospital ; Queensland Government Health Research Fellowship
WOS记录号WOS:000353348500015
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52092
专题北京大学第三临床医学院_肾内科
作者单位1.Univ Queensland, Princess Alexandra Hosp, Dept Nephrol, Brisbane, Qld, Australia
2.Peking Univ, Hosp 3, Div Nephrol, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Stevenson, Sarah,Tang, Wen,Cho, Yeoungjee,et al. THE ROLE OF MONITORING VANCOMYCIN LEVELS IN PATIENTS WITH PERITONEAL DIALYSIS-ASSOCIATED PERITONITIS[J]. PERITONEAL DIALYSIS INTERNATIONAL,2015,35(2):222-228.
APA Stevenson, Sarah.,Tang, Wen.,Cho, Yeoungjee.,Mudge, David W..,Hawley, Carmel M..,...&Johnson, David W..(2015).THE ROLE OF MONITORING VANCOMYCIN LEVELS IN PATIENTS WITH PERITONEAL DIALYSIS-ASSOCIATED PERITONITIS.PERITONEAL DIALYSIS INTERNATIONAL,35(2),222-228.
MLA Stevenson, Sarah,et al."THE ROLE OF MONITORING VANCOMYCIN LEVELS IN PATIENTS WITH PERITONEAL DIALYSIS-ASSOCIATED PERITONITIS".PERITONEAL DIALYSIS INTERNATIONAL 35.2(2015):222-228.
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