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学科主题: 临床医学
题名:
Human umbilical cord blood cells express neurotrophic factors
作者: Fan, CG1; Zhang, QJ1; Tang, FW1; Han, ZB1; Wang, GS1; Han, ZC1
关键词: cord blood (CB) ; glial derived neurotrophic factor (GDNF) ; brain-derived neurotrophic factor (BDNF) ; nerve growth factor (NGF) ; neurotrophin-3 (NT-3) ; neurotrophin-4/5 (NT-4/5)
刊名: NEUROSCIENCE LETTERS
发表日期: 2005-06-03
DOI: 10.1016/j.neulet.2005.01.070
卷: 380, 期:3, 页:322-325
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: CENTRAL-NERVOUS-SYSTEM ; STEM-CELLS ; BEHAVIORAL DEFICITS ; MOUSE MODEL ; IN-VITRO ; STROKE ; INJURY ; TRANSPLANTATION ; INFUSION ; NEURONS
英文摘要:

Freshly isolated or culture-expanded human umbilical cord blood mononuclear cells (CBMNCs) have been known to express neural phenotypes in vitro and to differentiate into neural cells and improve neurological function recovery after being administrated into rodent models of neurological diseases. However, the mechanism of action remains unclear. The present study observed that CBMNCs expressed higher level mRNAs of several neurotrophic factors than adult peripheral blood mononuclear cells (PBMCs). In addition, a significantly increase in the levels of brain-derived neurotrophic factor (BDNF) and neurotrophin-4/5 (NT4/5) was found in culture supernatants of CBMNCs compared to that of PBMNCs. These findings indicate that CBMNCs express several neurotrophic factors and suggest that the neurotrophic factors secreted by CBMNCs may be responsible for amelioration of central nervous system deficits in animal models after CBMNC administration. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000229160000025
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52094
Appears in Collections:北京大学第二临床医学院_神经外科_期刊论文

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作者单位: 1.Chinese Acad Med Sci, Inst Hematol, State Key Lab Expt Hematol, Natl Res Ctr Stem Cell Engn & Technol, Tianjin, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Neurosurg, Beijing 100871, Peoples R China

Recommended Citation:
Fan, CG,Zhang, QJ,Tang, FW,et al. Human umbilical cord blood cells express neurotrophic factors[J]. NEUROSCIENCE LETTERS,2005,380(3):322-325.
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