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Human umbilical cord blood cells express neurotrophic factors
Fan, CG1; Zhang, QJ1; Tang, FW1; Han, ZB1; Wang, GS1; Han, ZC1
关键词Cord Blood (Cb) Glial Derived Neurotrophic Factor (Gdnf) Brain-derived Neurotrophic Factor (Bdnf) Nerve Growth Factor (Ngf) Neurotrophin-3 (Nt-3) Neurotrophin-4/5 (Nt-4/5)
刊名NEUROSCIENCE LETTERS
2005-06-03
DOI10.1016/j.neulet.2005.01.070
380期:3页:322-325
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]CENTRAL-NERVOUS-SYSTEM ; STEM-CELLS ; BEHAVIORAL DEFICITS ; MOUSE MODEL ; IN-VITRO ; STROKE ; INJURY ; TRANSPLANTATION ; INFUSION ; NEURONS
英文摘要

Freshly isolated or culture-expanded human umbilical cord blood mononuclear cells (CBMNCs) have been known to express neural phenotypes in vitro and to differentiate into neural cells and improve neurological function recovery after being administrated into rodent models of neurological diseases. However, the mechanism of action remains unclear. The present study observed that CBMNCs expressed higher level mRNAs of several neurotrophic factors than adult peripheral blood mononuclear cells (PBMCs). In addition, a significantly increase in the levels of brain-derived neurotrophic factor (BDNF) and neurotrophin-4/5 (NT4/5) was found in culture supernatants of CBMNCs compared to that of PBMNCs. These findings indicate that CBMNCs express several neurotrophic factors and suggest that the neurotrophic factors secreted by CBMNCs may be responsible for amelioration of central nervous system deficits in animal models after CBMNC administration. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

语种英语
WOS记录号WOS:000229160000025
引用统计
被引频次:53[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52094
专题北京大学第二临床医学院_神经外科
作者单位1.Chinese Acad Med Sci, Inst Hematol, State Key Lab Expt Hematol, Natl Res Ctr Stem Cell Engn & Technol, Tianjin, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Neurosurg, Beijing 100871, Peoples R China
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GB/T 7714
Fan, CG,Zhang, QJ,Tang, FW,et al. Human umbilical cord blood cells express neurotrophic factors[J]. NEUROSCIENCE LETTERS,2005,380(3):322-325.
APA Fan, CG,Zhang, QJ,Tang, FW,Han, ZB,Wang, GS,&Han, ZC.(2005).Human umbilical cord blood cells express neurotrophic factors.NEUROSCIENCE LETTERS,380(3),322-325.
MLA Fan, CG,et al."Human umbilical cord blood cells express neurotrophic factors".NEUROSCIENCE LETTERS 380.3(2005):322-325.
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