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学科主题: 临床医学
题名:
beta 3 adrenergic receptor polymorphism and obesity-related phenotypes in hypertensive patients
作者: Hao, K1; Peng, SJ1; Xing, HX1; Yu, YX1; Huang, AQ1; Hong, XM1; Wang, YP1; Chen, CZ1; Wang, BY1; Zhang, XJ1; Liu, J1; Zhu, GY1; Huo, Y1; Chen, DF1; Zhao, XT1; Ronnenberg, A1; Wu, D1; Niu, T1; Xu, XP1
关键词: beta 3 adrenergic receptor ; polymorphism ; obesity phenotypes ; gender
刊名: OBESITY RESEARCH
发表日期: 2004
卷: 12, 期:1, 页:125-130
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Endocrinology & Metabolism ; Nutrition & Dietetics
研究领域[WOS]: Endocrinology & Metabolism ; Nutrition & Dietetics
关键词[WOS]: BETA(3)-ADRENERGIC RECEPTOR GENE ; BETA-3 ADRENERGIC-RECEPTOR ; TRP64ARG POLYMORPHISM ; INSULIN-RESISTANCE ; DIABETES-MELLITUS ; ASSOCIATION ; MUTATION ; WEIGHT ; POPULATION ; VARIANT
英文摘要:

Objectives: Obesity is a complex trait that is affected by both environmental and genetic risk factors. The 03 adrenergic receptor (ADRB3) is expressed in adipose tissue and plays a role in energy metabolism. A missense mutation on codon 64 of this gene (W64R) is associated with receptor malfunction. Previous studies examining the relation between this polymorphism and obesity produced inconsistent findings. The current study assessed the association between the W64R genotype and obesity-related phenotypes, including body weight, BMI, and serum triglycerides, cholesterol, and glucose.

Research Methods and Procedures: We determined the ADRB3 W64R genotypes and fasting serum lipid and glucose concentrations for 695 hypertensive adults (336 men, 359 women) from a rural county in Anhui Province, China. Multivariate linear regression models were fit to detect associations between the genetic polymorphism and obesity-related phenotypes.

Results: The ADRB3 W64R polymorphism was significantly associated with body weight and BMI in men but not in women. After controlling for potential confounding variables, men who were homozygous for the R64 allele were 11.8 kg heavier (p < 0.001) and had a BMI that was 3.7 kg/m(2) greater (p = 0.001) than men who were homozygous for the W64 allele. Serum concentrations of lipids and glucose were found not associated with the genetic polymorphism.

Discussion: The ADRB3 R64 allele was associated with increased body weight and BMI in men but not in women. The genetic association was not modified by triglyceride, cholesterol, blood glucose, or blood pressure levels of the subjects.

语种: 英语
WOS记录号: WOS:000188535900017
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52096
Appears in Collections:北京大学第一临床医学院_心血管内科_期刊论文

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作者单位: 1.Anhui Med Univ, Inst Biomed, Hefei, Peoples R China
2.Harvard Univ, Sch Publ Hlth, Program Populat Genet, Boston, MA 02115 USA
3.Univ Sci & Technol China, Sch Life Sci, Hefei 230026, Peoples R China
4.Peking Univ, Sch Med, Dept Genet & Cell Biol, Ctr Eco Genet & Reprod Hlth, Beijing 100871, Peoples R China
5.Peking Univ, Affiliated Hosp 1, Dept Cardiovasc Dis, Beijing 100871, Peoples R China

Recommended Citation:
Hao, K,Peng, SJ,Xing, HX,et al. beta 3 adrenergic receptor polymorphism and obesity-related phenotypes in hypertensive patients[J]. OBESITY RESEARCH,2004,12(1):125-130.
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