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学科主题: 临床医学
题名:
In situ mechanical analysis of cardiomyocytes at nano scales
作者: Liu, Yuansheng1,2; Feng, Jiantao2; Shi, Liang3; Niu, Ruibin4; Sun, Quanmei2; Liu, Hao5; Li, Jing2; Guo, Jihong1; Zhu, Jihong1; Han, Dong2
刊名: NANOSCALE
发表日期: 2012
DOI: 10.1039/c1nr11303h
卷: 4, 期:1, 页:99-102
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
研究领域[WOS]: Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
关键词[WOS]: ATOMIC-FORCE MICROSCOPY ; RAT VENTRICULAR MYOCYTES ; CARDIAC MYOCYTES ; CONTRACTION ; IBUTILIDE ; CELLS
英文摘要:

Nanomechanical behaviors of single living cardiomyocytes are quantitatively observed using calculated torsions and deflections of an AFM cantilever. The lateral contractions are related to the calcium intensity within rather than the vertical beating power of the cardiomyocytes. Drug-induced nanomechanical changes of cardiomyocytes were further investigated by measuring lateral contractions in real time.

语种: 英语
所属项目编号: 90709054 ; 2006CB705600 ; 2009CB930200
项目资助者: National Science Foundation of China ; project of 973 in Ministry of Science and Technology of China ; Peking University People&prime ; s Hospital
WOS记录号: WOS:000297848500009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52100
Appears in Collections:北京大学第二临床医学院_急诊科_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Emergency Dept, Beijing 100044, Peoples R China
2.Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China
3.306 Hosp, Dept Stomatoi, Beijing 100101, Peoples R China
4.Ordos Cent Hosp, Clin Lab, Ordos 017000, Peoples R China
5.First Peoples Hosp Hangzhou City, Intens Care Unit, Hangzhou 310006, Zhejiang, Peoples R China

Recommended Citation:
Liu, Yuansheng,Feng, Jiantao,Shi, Liang,et al. In situ mechanical analysis of cardiomyocytes at nano scales[J]. NANOSCALE,2012,4(1):99-102.
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