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学科主题临床医学
The clinical implication of SS18-SSX fusion gene in synovial sarcoma
Ren, T.; Lu, Q.; Guo, W.; Lou, Z.; Peng, X.; Jiao, G.; Sun, Y.
关键词Synovial Sarcoma Ss18-ssx 1 Ss18-ssx 2 Survival Analysis
刊名BRITISH JOURNAL OF CANCER
2013-10-15
DOI10.1038/bjc.2013.547
109期:8页:2279-2285
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]SOFT-TISSUE SARCOMA ; SYT-SSX ; RETROSPECTIVE ANALYSIS ; PROGNOSTIC IMPLICATION ; DOWN-REGULATION ; ADULT PATIENTS ; IN-VITRO ; TUMORS ; MULTICENTER ; POPULATION
英文摘要

Background: The aim of this study is to evaluate distribution and clinical impact of the SS18-SSX fusion gene in patients with synovial sarcoma in China.

Methods: We collected and analysed the clinical data of 88 patients using univariate and multivariate survival analysis. HEK 293T and NIH 3T3 cell lines were transfected with the SS18-SSX1 or SS18-SSX2 gene to determine the respective involvement of these fusion genes in cell proliferation and invasion.

Results: Overall survival was significantly better among SS18-SSX2 cases (P = 0.001), FNCLCC grade 2 cases (P<0.001), and UICC stage 1 or 2 (P<0.001) by univariate and multivariate survival analysis. SS18-SSX1-positive cells were more proliferative and invasive than SS18-SSX2-positive cells.

Conclusion: SS18-SSX fusion type is a significant prognostic factor for patients with synovial sarcoma.

语种英语
WOS记录号WOS:000325795000028
项目编号81001193 ; 20100001120077
资助机构National Natural Science Foundation of China ; Specialised Research Fund for the Doctoral Programme of Higher Education of China
引用统计
被引频次:19[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52104
专题北京大学第二临床医学院_骨肿瘤科
北京大学药学院_天然药物与仿生药物国家重点实验室
北京大学口腔医学院_外科
北京大学公共卫生学院_学院办公室
作者单位Peking Univ, Peoples Hosp, Musculoskeletal Tumor Ctr, Beijing 100044, Peoples R China
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Ren, T.,Lu, Q.,Guo, W.,et al. The clinical implication of SS18-SSX fusion gene in synovial sarcoma[J]. BRITISH JOURNAL OF CANCER,2013,109(8):2279-2285.
APA Ren, T..,Lu, Q..,Guo, W..,Lou, Z..,Peng, X..,...&Sun, Y..(2013).The clinical implication of SS18-SSX fusion gene in synovial sarcoma.BRITISH JOURNAL OF CANCER,109(8),2279-2285.
MLA Ren, T.,et al."The clinical implication of SS18-SSX fusion gene in synovial sarcoma".BRITISH JOURNAL OF CANCER 109.8(2013):2279-2285.
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