北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第二临床医学院  > 骨肿瘤科  > 期刊论文
学科主题: 临床医学
题名:
The clinical implication of SS18-SSX fusion gene in synovial sarcoma
作者: Ren, T.; Lu, Q.; Guo, W.; Lou, Z.; Peng, X.; Jiao, G.; Sun, Y.
关键词: synovial sarcoma ; SS18-SSX 1 ; SS18-SSX 2 ; survival analysis
刊名: BRITISH JOURNAL OF CANCER
发表日期: 2013-10-15
DOI: 10.1038/bjc.2013.547
卷: 109, 期:8, 页:2279-2285
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: SOFT-TISSUE SARCOMA ; SYT-SSX ; RETROSPECTIVE ANALYSIS ; PROGNOSTIC IMPLICATION ; DOWN-REGULATION ; ADULT PATIENTS ; IN-VITRO ; TUMORS ; MULTICENTER ; POPULATION
英文摘要:

Background: The aim of this study is to evaluate distribution and clinical impact of the SS18-SSX fusion gene in patients with synovial sarcoma in China.

Methods: We collected and analysed the clinical data of 88 patients using univariate and multivariate survival analysis. HEK 293T and NIH 3T3 cell lines were transfected with the SS18-SSX1 or SS18-SSX2 gene to determine the respective involvement of these fusion genes in cell proliferation and invasion.

Results: Overall survival was significantly better among SS18-SSX2 cases (P = 0.001), FNCLCC grade 2 cases (P<0.001), and UICC stage 1 or 2 (P<0.001) by univariate and multivariate survival analysis. SS18-SSX1-positive cells were more proliferative and invasive than SS18-SSX2-positive cells.

Conclusion: SS18-SSX fusion type is a significant prognostic factor for patients with synovial sarcoma.

语种: 英语
所属项目编号: 81001193 ; 20100001120077
项目资助者: National Natural Science Foundation of China ; Specialised Research Fund for the Doctoral Programme of Higher Education of China
WOS记录号: WOS:000325795000028
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52104
Appears in Collections:北京大学第二临床医学院_骨肿瘤科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: Peking Univ, Peoples Hosp, Musculoskeletal Tumor Ctr, Beijing 100044, Peoples R China

Recommended Citation:
Ren, T.,Lu, Q.,Guo, W.,et al. The clinical implication of SS18-SSX fusion gene in synovial sarcoma[J]. BRITISH JOURNAL OF CANCER,2013,109(8):2279-2285.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Ren, T.]'s Articles
[Lu, Q.]'s Articles
[Guo, W.]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Ren, T.]‘s Articles
[Lu, Q.]‘s Articles
[Guo, W.]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace