IR@PKUHSC  > 北京大学第三临床医学院  > 放射科
学科主题临床医学
Comparative Analysis by Magnetic Resonance Imaging of Extracellular Space Diffusion and Interstitial Fluid Flow in the Rat Striatum and Thalamus
Zuo, Long1,2; Li, Kai1,3; Han, Hongbin1
刊名APPLIED MAGNETIC RESONANCE
2015-06-01
DOI10.1007/s00723-015-0670-7
46期:6页:623-632
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Physics, Atomic, Molecular & Chemical ; Spectroscopy
资助者National Natural Science Foundation of China ; National key developmental program for scientific instrument and equipment ; National Science and Technology Pillar Program during the Twelve Five-year Plan Period of China ; National Natural Science Foundation of China ; National key developmental program for scientific instrument and equipment ; National Science and Technology Pillar Program during the Twelve Five-year Plan Period of China
研究领域[WOS]Physics ; Spectroscopy
关键词[WOS]WATER TRANSPORT ; QUANTITATIVE ASSESSMENT ; BRAIN ; AQUAPORIN-4 ; DELIVERY ; DISEASE ; MODEL ; MRI ; RECEPTORS ; INJURY
英文摘要

Drug delivery to the brain remains a challenge due to the blood-brain barrier. Localized injection of drug therapies represents a promising alternative once the diffusion characteristics of different brain regions have been evaluated. Extracellular space diffusion and interstitial fluid flow of the striatum and thalamus in the rat brain were simultaneously compared using magnetic resonance imaging and the tracer gadolinium-diethylenetriaminepentaacetic acid (Gd-DTPA). The diffusion parameters, volume distribution, and half-life time were quantified. While there was extensive diffusion of Gd-DTPA in the striatum, Gd-DTPA was rapidly cleared and had a shorter half-life time in the thalamus. The increased clearance rate and shorter half-life of the tracer in the thalamus were associated with increased expression of Aquaporin-4. The tortuosity of the extracellular space did not show a statistically significant difference between the two regions examined. Our research provides a new reference for brain interstitial drug delivery to treat central nervous system diseases and a better understanding of the brain microenvironment.

语种英语
所属项目编号81171080 ; 61450004 ; 2011YQ030114 ; 2012BAI15B009
资助者National Natural Science Foundation of China ; National key developmental program for scientific instrument and equipment ; National Science and Technology Pillar Program during the Twelve Five-year Plan Period of China ; National Natural Science Foundation of China ; National key developmental program for scientific instrument and equipment ; National Science and Technology Pillar Program during the Twelve Five-year Plan Period of China
WOS记录号WOS:000354620900002
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52105
Collection北京大学第三临床医学院_放射科
作者单位1.Beijing Jishuitan Hosp, Dept Radiol, Beijing 100035, Peoples R China
2.Peking Univ, Hosp 3, Dept Radiol, Beijing 100191, Peoples R China
3.Beijing Key Lab Magnet Resonance Imaging Device &, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Zuo, Long,Li, Kai,Han, Hongbin. Comparative Analysis by Magnetic Resonance Imaging of Extracellular Space Diffusion and Interstitial Fluid Flow in the Rat Striatum and Thalamus[J]. APPLIED MAGNETIC RESONANCE,2015,46(6):623-632.
APA Zuo, Long,Li, Kai,&Han, Hongbin.(2015).Comparative Analysis by Magnetic Resonance Imaging of Extracellular Space Diffusion and Interstitial Fluid Flow in the Rat Striatum and Thalamus.APPLIED MAGNETIC RESONANCE,46(6),623-632.
MLA Zuo, Long,et al."Comparative Analysis by Magnetic Resonance Imaging of Extracellular Space Diffusion and Interstitial Fluid Flow in the Rat Striatum and Thalamus".APPLIED MAGNETIC RESONANCE 46.6(2015):623-632.
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